Edit your profile

Richard M Longnecker

Feinberg School of Medicine, Feinberg Basic, Microbiology-Immunology

Richard M Longnecker

Research Interest Keywords

Cancer Biology, Signal Transduction, Systems Biology, Viral Oncology, Viral Pathogenesis, Virology

Office phone

312/503-0467

Email

Research Statement: Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis. First, the molecular basis EBV transformation and how it relates to cancer is being investigated. The laboratory is currently screening selective inhibitors that may be beneficial in EBV-associated cancers such as Hodgkin lymphoma, Burkitt lymphoma and proliferative disorders that occur in HIV/AIDS and transplant patients. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections. Finally, the laboratory is investigating the function of herpesvirus encoded proteins and the cellular receptors that are important for infection both using in vivo culture models as well as animal models. Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human host.
more >

Publications

more >

Similar Experts

more >

Journals

  •  
    Publications
  • Open details Journal of Virology
    53
  • Open details Virology
    24
  • Open details Proceedings of the National Academy of Sciences of the United States of America
    11
  • Open details Journal of General Virology
    6
  • Open details Methods in molecular biology (Clifton, N.J.)
    4
more >

Grants

>

Institutional Network

  • External Organizations
    Shared Pub.
  • Open details Harvard Medical School
    11
  • Open details University of Chicago
    11
  • Open details Stanford University School of Medicine
    10
  • Open details The University of North Carolina at Chapel Hill
    3
  • Open details University of Pennsylvania
    3
  • Open details Harvard University
    3
more >

Coauthor Network

  • External Coauthors
    Shared Pub.
  • Open details Elliott Kieff
    15
  • Open details Theodore S Jardetzky
    14
  • Open details Bernard Roizman
    6
  • Open details CL Miller
    5
  • Open details Andrew Marchini
    4
  • Open details Marija Backovic
    3