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Robert A Holmgren

Judd A. and Marjorie Weinberg College of Arts and Sciences, Weinberg Natural Sciences, Molecular Biosciences

Robert A Holmgren

Office phone

847/491-5460

Email

Research Statement: Our research group studies the process of pattern formation. In particular we are focused on the Hedgehog signal transduction pathway and its regulation of cell fate specification. Our present goals are to understand how the signal is relayed from the cell surface to the transcription factors Ci in Drosophila and homologous Gli1, 2, and 3 transcription factors in mammals. We are pursuing three lines of research: In collaboration with Andreas Matouschek’s group, we are examining how the proteasome partially degrades Ci, Gli2 and Gli3. This process appears to depend upon the tightly folded zinc finger domain and a stretch of amino acids with low complexity. By exchanging domains and modifying their sequence and relative position, we hope to understand how partial proteolysis is accomplished. To identify additional components of the Hedgehog signal transduction cascade, an RNAi suppressor/enhancer screen has been carried out in a fu mutant background. To date we have screened kinases, phosphatases, acetylases, deacetylases, proteins that bind known components of the Hedgehog pathway and 1000 random genes. Roughly 50 genetic interactions were identified. The best candidates are being further characterized to identify which are directly involved in Hedgehog signaling and what aspects of the process they regulate. In collaboration with the Meade lab, we are testing a cobalt Schiff base that is specifically targeted to the Ci/Gli proteins for its ability to block the function of these transcription factors.
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Publications

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Similar Experts

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Journals

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    Publications
  • Open details Development
    6
  • Open details Developmental Biology
    6
  • Open details Proceedings of the National Academy of Sciences of the United States of America
    3
  • Open details Cell
    2
  • Open details Genes and Development
    2
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Grants

  • 1.

    Kathleen Janee Green; Navdeep Chandel; Rex Chisholm; John Crispino; Cara Gottardi; Robert Holmgren; William John Karpus; Carole LaBonne; Jonathan Licht; Rick McGee; Thomas O'Halloran; Mary Rundell; Gayle Woloschak; Teresa Woodruff

    Carcinogenesis Training Program

    7/1/2012 - 6/30/2017

    Document ID: 2T32CA009560-26

    Sponsor: National Cancer Institute

  • 2.

    Vadim Backman; Richard Carthew; Vinayak Dravid; Sheila Judge; Peter Andreas Kopp; John Marko; Andreas Matouschek; Adilson Motter; Thomas O'Halloran; Teri Wang Odom; Marcus Peter; Benette Phillips; Igal Szleifer; Jiping Wang; Xiaozhong Wang; Luis Amaral; Linda Broadbelt; John Crispino; Mark Hersam; Robert Holmgren; Carole LaBonne; Jonathan Licht; George Schatz; Jonathan Widom; Dirk Brockmann; William Kath; Joshua Leonard; Tomekia Simeon

    Coding, Decoding, Transfer, and Translation of Information in Cancer

    9/28/2009 - 7/31/2014

    Document ID: 3U54CA143869-04S1

    Sponsor: National Cancer Institute

  • 3.

    Andreas Matouschek; Mark Hersam; Robert Holmgren; John Marko; Thomas O'Halloran

    Coding, Decoding, Transfer, and Translation of Information in Cancer

    9/28/2009 - 7/31/2014

    Document ID: 3U54CA143869-04S1

    Sponsor: National Cancer Institute

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Institutional Network

  • External Organizations
    Shared Pub.
  • Open details Harvard University
    4
  • Open details University of Illinois
    2
  • Open details Northwestern University Department of Cell and Molecular Biology
    1
  • Open details Barry University
    1
  • Open details University of Washington Seattle
    1
  • Open details UC Berkeley
    1
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Coauthor Network

  • External Coauthors
    Shared Pub.
  • Open details V Corces
    2
  • Open details Cynthia K Motzny
    1
  • Open details R Freund
    1
  • Open details Nipam H Patel
    1
  • Open details Q Tian Wang
    1
  • Open details Mark A Lefers
    1