Shu Qian Liu

Research Statement: My research is focused on cardiovascular regenerative engineering, the engineering aspect of cardiovascular regenerative medicine. One of the ongoing research projects is to investigate the role of the liver in myocardial protection and regeneration following experimental myocardial ischemia. Hepatocytes can naturally respond to myocardial ischemia to express secreted factors, which contribute to the protection and regeneration of injured myocardium. These secreted factors can be identified, produced by recombinant biotechnology, and used to mitigate myocardial infarction and promote myocardial regeneration in coronary heart disease. Another research topic is enhancement of endothelial cell retention in arterial substitutes. Molecular engineering approaches are developed and used to activate endothelial cell adhesion-promoting molecules and/or suppress endothelial cell adhesion-inhibiting molecules, thus enhancing endothelial cell retention and mitigating arterial substitute intimal hyperplasia and restenosis. Overall, the goals of our research are to enhance protection and regeneration of injured myocardium and improve the performance of reconstructed arteries by developing and using engineering technologies.

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Publications

1.
2012

Shu Q. Liu; Brandon J. Tefft; Derek T. Roberts; Li-Qun Zhang; Yupeng Ren; Yan Chun Li; Yong Huang; Di Zhang; Harry R. Phillips; Yu H. Wu

Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia
American Journal of Physiology - Heart and Circulatory Physiology. 2012;303(12):H1446-H1458.
2.
2011

Shu Q. Liu; Brandon J. Tefft; Brian Zhang; Charley Liu; Yu H. Wu

Regulation of hepatic cell mobilization in experimental myocardial ischemia
Cellular and Molecular Bioengineering. 2011;4(4):693-707.
3.
2011

Brandon J. Tefft; Adrian M. Kopacz; Wing Kam Liu; Shu Q. Liu

Enhancing endothelial cell retention on ePTFE constructs by siRNA mediated SHP-1 gene silencing
Journal of Nanotechnology in Engineering and Medicine. 2011;2(1).

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Journals

Publications
Journal of Biomechanical Engineering

9
American Journal of Physiology - Heart and Circulatory Physiology

7
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

6
Annals of Biomedical Engineering

4
Journal of Biomechanics

4