Teresa K Woodruff

Research Statement: Woodruff’s role in understanding inhibin fluctuation in the ovary led to questions about ovarian follicle formation and persistence, which provides new ways to think about fertility preservation for young women with fertility-threatening conditions (NEJM, 2009). She examined the regulation of follicle function in vitro and established a collaboration with a biomaterial scientist, Lonnie Shea, to develop a 3-dimensional support system that would provide the necessary bio-integrity for follicle growth (Tissue Eng. 9:1013, 2003; News and Views in Nat. Med. 14:1178, 2008 and Nat. Med. 14:1182). These studies have been very productive and the current culture system supports live births of mice. The system is being adopted to non-human primate and human ovarian follicles. She coined the term oncofertility to describe this work. Finally, she has used physiological studies together with mathematical modeling to explore the kinetics of follicle formation and persistence in the mouse (Dev. Biol. 298:149 and Dev. Biol. 298:132). These studies reveal the necessary and sufficient nature of the initial follicle pool established in the ovary during the time of development (Nature Med, 14:1190, 2008). Hallmarks of Woodruff career have included a strong focus on ovarian biology, on interdisciplinary approaches to problems, and application of the overall health of women.

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Publications

1.
2013

J.S. Wu; A.M. Kim; R. Bleher; B.D. Myers; R.G. Marvin; H. Inada; K. Nakamura; X.F. Zhang; E. Roth; S.Y. Li; et al.

Imaging and elemental mapping of biological specimens with a dual-EDS dedicated scanning transmission electron microscope
Ultramicroscopy. 2013;128:24-31.
2.
2013

Ze-Xu Jiao; Teresa K. Woodruff

Follicle microenvironment-associated alterations in gene expression in the mouse oocyte and its polar body
Fertility and Sterility. 2013;99(5):1453-1459e1.
3.
2013

Richard W. Ahn; Susan L. Barrett; Meera R. Raja; Jennifer K. Jozefik; Lidia Spaho; Haimei Chen; Marcel B. Bally; Andrew P. Mazar; Michael J. Avram; Jane N. Winter; et al.

Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo
PLoS ONE. 2013;8(3).

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Journals

Publications
Endocrinology

32
Biology of Reproduction

19
Cancer treatment and research

13
Journal of Clinical Endocrinology and Metabolism

11
Fertility and Sterility

10

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Grants

1.

Teresa Woodruff; Michael Avram; J.Julie Kim; Takeshi Kurita; Mary Ellen Pavone; Lonnie Shea

Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System

9/17/2012 - 8/31/2014
Document ID: 1UH2ES022920-01
Sponsor: National Institute of Environmental Health Sciences
2.

Teresa Woodruff; Mary Ellen Pavone

Beyond the Ivory Tower: Providing Clinical Eduction to Hospitals and Practices Across Illinois Through Telesynergy

9/1/2012 - 8/31/2013
Document ID: Agmt9/25/12
Sponsor: Northwestern Memorial Foundation
3.

Kathleen Janee Green; Navdeep Chandel; Rex Chisholm; John Crispino; Cara Gottardi; Robert Holmgren; William John Karpus; Carole LaBonne; Jonathan Licht; Rick McGee; Thomas O'Halloran; Mary Rundell; Gayle Woloschak; Teresa Woodruff

Carcinogenesis Training Program

7/1/2012 - 6/30/2017
Document ID: 2T32CA009560-26
Sponsor: National Cancer Institute

Institutional Network

Internal Organizations

Shared Pub.
Chemical and Biological Engineering

49
Center for Reproductive Science

22
Molecular Biosciences

22
Chemistry

9
Surgery, Breast Surgery Divisioin

8
Chemistry of Life Processes Institute

7

External Organizations

Shared Pub.
Genentech Incorporated

18
Baylor College of Medicine

9
Oregon National Primate Research Center

9
University of Chicago

8
Massachusetts General Hospital

5
University of Pennsylvania

5

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External Coauthors

Shared Pub.
Jennie P Mather

15
Lynne Krummen

9
Richard L Stouffer

9
Martin M Matzuk

8
Mary B Zelinski

4
Felice Petraglia

4

Teresa K Woodruff Feinberg School of Medicine, Feinberg Clinical, Obstetrics and Gynecology

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Teresa K Woodruff
Feinberg School of Medicine, Feinberg Clinical, Obstetrics and Gynecology