Warren A Kibbe

Research Statement: Dr Kibbe is the principal investigator for the Patient Study Calendar module software development project, the caBIG development project that has developed a syntactically and semantically harmonized interoperable patient study calendar using agile design practices. Dr. Kibbe is the co-PI of the NIH-funded Dictyostelium Model Organism Database dictyBase. He is a proponent of Agile software development methodologies and the Agile Unified Process Framework and the application of these to biomedical research problems. Dr. Kibbe's group has developed NOTIS, the clinical trial information management system used for all cancer trials at Northwestern and by the genotype/phenotype biorepository NUgene (http://www.nugene.org) as the source of identified information on participant in NUgene. In NUCATS, the Northwestern CTSA organization, Dr. Kibbe recently received ARRA funding to extend NOTIS to all disease areas at Northwestern, and release the eNOTIS project as a CTSA-sponsored open source project. He is also a key participant in building a computable research representation of clinical data, through his work with the Northwestern Medicine Enterprise Data Warehouse, the caBIG Clinical Annotations Engine (which is designed to build a computable representation of pathology reports from the Cerner and Epic EMR systems), and ontology efforts, including being a co-founder of the Disease Ontology (http:/diseaseontology.sourceforge.net) and the semantically computable BRIDG domain analysis model that is being jointly developed by members of HL7, CDISC and caBIG to represent clinical research information and the semantics necessary to conduct clinical trials.

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Publications

1.
2012

Wei Xu; Huisong Wang; Wenqing Cheng; Dong Fu; Tian Xia; Warren A. Kibbe; Simon M. Lin

A Framework for Annotating Human Genome in Disease Context
PLoS ONE. 2012;7(12).
2.
2012

Xiao Zhang; Andrew D. Wallace; Pan Du; Simon Lin; Andrea A. Baccarelli; Hongmei Jiang; Nadereh Jafari; Yinan Zheng; Hehuang Xie; Marcelo Bento Soares; et al.

Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro
Environmental Toxicology and Pharmacology. 2012;34(3):959-968.
3.
2012

Xiao Zhang; Andrew D. Wallace; Pan Du; Warren A. Kibbe; Nadereh Jafari; Hehuang Xie; Simon Lin; Andrea Baccarelli; Marcelo Bento Soares; Lifang Hou

DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis. 2012;53(7):542-549.

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Publications
Nucleic Acids Research

9
Bioinformatics

3
Methods in Molecular Biology

2
BMC Genomics

2
BMC Medical Informatics and Decision Making

1

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Grants

1.

Warren Kibbe; Min-Woong Sohn

NCS Navigator IMS Hub

9/28/2012 - 9/27/2013
Document ID: HHSN275201200027C
Sponsor: National Institute of Child Health and Human Development
2.

Jane Holl; Warren Kibbe

National Children's Study Greater Chicago Study Center – 6-month Continuation

9/28/2012 - 3/31/2013
Document ID: HHSN275201200025C
Sponsor: National Institute of Child Health and Human Development
3.

Richard Gershon; Jane Holl; Warren Kibbe; Cindy Nowinski

National Children's Study: Vanguard Study (South ROC)

9/27/2012 - 9/26/2017
Document ID: HHSN275201200007I
Sponsor: National Institute of Child Health and Human Development

Institutional Network

Internal Organizations

Shared Pub.
Cell and Molecular Biology

8
Preventive Medicine

7
Center for Genetic Medicine

3
Medicine, Hematology Oncology Division

3
Center for Sleep and Circadian Biology

2
Pediatrics

2

External Organizations

Shared Pub.
Jackson Laboratory

4
California Institute of Technology

4
University of Illinois at Chicago

3
Marshfield Clinic

3
Carnegie Institution of Washington

2
University of Arkansas for Medical Sciences

2

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Internal Coauthors

Shared Pub.
Rex L Chisholm

8
Gang Feng

5
Lifang Hou

3
Nadereh Jafari

3
Chiang-Ching Huang

2
Hongmei Jiang

2

External Coauthors

Shared Pub.
Simon Lin

3
Pan Du

3
H Drabkin

2
JE Hirschman

2
V Wood

2
Stephanie Pretel

2

Warren A Kibbe Research Centers and Institutes, NU Clinical and Translational Sciences Institute

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Warren A Kibbe
Research Centers and Institutes, NU Clinical and Translational Sciences Institute