Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Rarity of toxigenic Clostridium difficile infections after hematopoietic stem cell transplantation: Implications for symptomatic management of diarrhea
Bone Marrow Transplantation. 2002;30(8):517-519.Abstract
Diarrhea is a common complication of high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT). The frequent and prolonged use of multiple antibiotics in this setting can predispose to infection with toxigenic Clostridium difficile and the development of pseudomembranous colitis. Anti-motility agents are usually not administered in this setting until C. difficile infection has been excluded. The objective of this study was to determine the incidence of C. difficile toxin (CDT) positivity at the time of initial diarrhea in HSCT recipients, and to see if the practice of ensuring negative CDT assays prior to initiating symptomatic management of diarrhea needs modification. One hundred and nineteen patients with malignant diseases undergoing autologous or allogeneic HSCT were studied to determine the incidence of diarrhea and CDT positivity with initial diarrhea. One hundred and nine (91%) had diarrhea. Of these, only seven (6%) were CDT+ at the time of initial diarrhea. The median interval between onset of diarrhea and starting symptomatic anti-diarrheal therapy was 1 day. There were no significant differences between the patients with CDT+ diarrhea and the others in terms of timing or severity of diarrhea, number or duration of antibiotic usage, or leukocyte count. The infection resolved in all patients with metronidazole therapy. Our data suggest that the incidence of CDT+ diarrhea is low in HSCT recipients. Concern about C. difficile infection should not delay symptomatic therapy of initial diarrhea in HSCT recipients.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Sejean Sohn; Michael Climo; Daniel Diekema; Victoria Fraser; Loreen Herwaldt; Susan Marino; Gary Noskin; Trish Perl; Xiaoyan Song; Jerome Tokars; et al.Infection Control and Hospital Epidemiology. 2005;26(8):676-679.
Christina Marciniak; David Chen; Adam C. Stein; Patrick E. SemikArchives of Physical Medicine and Rehabilitation. 2006;87(8):1086-1090.
L. Boggio; R. Pooley; S.I. Roth; J.N. WinterBone Marrow Transplantation. 2000;25(3):321-326.
Appears in this Document