Christian Paul Petersen

Judd A. and Marjorie Weinberg College of Arts and Sciences, Weinberg Natural Sciences, Molecular Biosciences

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Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration

Christian P. Petersen; Peter W. Reddien (Profiled Author: Christian Paul Petersen)

Science. 2011;332(6031):852-855.

Regeneration requires initiation of programs tailored to the identity of missing parts. Head-versus-tail regeneration in planarians presents a paradigm for study of this phenomenon. After injury, Wnt signaling promotes tail regeneration. We report that wounding elicits expression of the Wnt inhibitor notum preferentially at anterior-facing wounds. This expression asymmetry occurs at essentially any wound, even if the anterior pole is intact. Inhibition of notum with RNA interference (RNAi) causes regeneration of an anterior-facing tail instead of a head, and double-RNAi experiments indicate that notum inhibits Wnt signaling to promote head regeneration. notum expression is itself controlled by Wnt signaling, suggesting that regulation of feedback inhibition controls the binary head-tail regeneration outcome. We conclude that local detection of wound orientation with respect to tissue axes results in distinct signaling environments that initiate appropriate regeneration responses.

PMID: 21566195     PMCID: PMC3320723

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