Thomas McDade Judd A. and Marjorie Weinberg College of Arts and Sciences, Weinberg Social Sciences, Anthropology

Thomas McDade

    Judd A. and Marjorie Weinberg College of Arts and Sciences
    Weinberg Social Sciences
    Anthropology
    Current Appointments:

    Professor; Anthropology; Judd A. and Marjorie Weinberg College of Arts and Sciences

    Professor; Institute for Policy Research; Research Centers and Institutes

    Professor; School of Education and Social Policy

    Professor; Medical Social Sciences; Feinberg School of Medicine

    Research Centers and Institutes
    Institute for Policy Research
    Current Appointments:

    Professor; Anthropology; Judd A. and Marjorie Weinberg College of Arts and Sciences

    Professor; Institute for Policy Research; Research Centers and Institutes

    Professor; School of Education and Social Policy

    Professor; Medical Social Sciences; Feinberg School of Medicine

Research Interest Keywords

Biocultural perspectives on health and human development; medical anthropology

Office phone

847/467-4304

Email

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Analysis of variability of high sensitivity C-reactive protein in lowland ecuador reveals no evidence of chronic low-grade inflammation

Thomas W. Mcdade; Paula S. Tallman; Felicia C. Madimenos; Melissa A. Liebert; Tara J. Cepon; Lawrence S. Sugiyama; James Josh Snodgrass

(Profiled Author: Thomas McDade)

American Journal of Human Biology. 2012;24(5):675-681.

Abstract

Objectives: C-reactive protein (CRP) is a central component of innate immune defenses, and high sensitivity CRP has emerged as an important biomarker of chronic inflammation and cardiovascular disease risk. Prior analyses of CRP variability have reported stable between-individual differences in CRP over time, but a limitation of current knowledge is that it is based on research conducted in post-epidemiologic transition populations. Methods: This study evaluated CRP variability among adults in the southeastern region of the Ecuadorian Amazon where rates of infectious diseases remain high. Blood samples were collected from 52 adults at four weekly sampling intervals and were quantified using a high-sensitivity immunoassay. Results: Median CRP concentration was 0.52 mg/l. About 34.6% of participants had CRP >3 mg/l at one time point, but no individuals had CRP >3 mg/l across two or more sampling intervals, and within-individual correlations revealed low levels of stable, between-individual differences in CRP. The application of current guidelines for the assessment of chronic inflammation failed to detect a single case of "high risk" CRP. Conclusions: This study is the first to investigate CRP variability in a nonindustrialized, high infectious disease environment. It documents a pattern of variation over time that is distinct from prior research, with no evidence for chronic low-grade inflammation. These results may have substantial implications for research on inflammation and diseases of aging globally, as well as for scientific understandings of the regulation of inflammation. © 2012 Wiley Periodicals, Inc.


PMID: 22639072    

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