Tatyana Simuni Feinberg School of Medicine, Feinberg Clinical, Neurology

Tatyana Simuni

    Feinberg School of Medicine
    Feinberg Clinical
    Neurology
    Current Appointments:

    Professor; Neurology; Feinberg School of Medicine

    Arthur C. Nielsen, Jr. Research Professorship in Parkinson's Disease and Movement Disorders; Neurology; Feinberg School of Medicine

Research Interest Keywords

Atypical Parkinsonian Syndromes, Balance Disorders, Blepharospasm, Botox Injections, Clinical Trial Methodology, Drug Discovery, Dystonia, Essential Tremor, Gait Disorders, Lewy Body Dementia, Movement Control, Movement Disorders, Parkinson's Disease

Office phone

312/503-2970

Email

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.


Mobility, mood and site of care impact health related quality of life in Parkinson's disease

J.G. Nutt; A.D. Siderowf; M. Guttman; P.N. Schmidt; J.I. Zamudio; S.S. Wu; M.S. Okun; T. Simuni; S.A. Parashos; N.A. Dahodwala; et al.

(Profiled Author: Tatyana Simuni)

Parkinsonism and Related Disorders. 2014;20(3):274-279.

Abstract

Objective: Examine the correlates of Health Related Quality of Life (HRQL) in a large cohort of Parkinson's disease (PD) patients from National Parkinson Foundation (NPF) Centers of Excellence (COEs). Background: Improving outcomes for PD will depend upon uncovering disease features impacting HRQL to identify targets for intervention and variables for risk-adjustment models. Differences in HRQL outcomes between COEs could uncover modifiable aspects of care delivery. Methods: This cross-sectional study examined the relative contribution of demographic, social, clinical and treatment features potentially related to HRQL, as measured by the PDQ-39, in 4601 consecutive subjects from 18 COEs. Stepwise linear regression was utilized to identify correlates of HRQL. Results: The variability in the PDQ-39 summary index score correlated with H&Y stage (R2=22%), Timed up and Go (TUG) (17%), disease duration (11%), comorbidities (8%), cognitive status (8%), antidepressant use (6%) and center at which a patient received care (5%). Stepwise regression reordered the importance of the variables, with the H&Y first and TUG and the center becoming equal and the second most important variables determining the PDQ-39 total score. All independent variables together accounted for 44% of the variability in HRQL. Conclusions: We confirmed many but not all HRQL associations found in smaller studies. A novel observation was that the site of care was an important contributor to HRQL, suggesting that comparison of outcomes and processes among centers may identify best practices. © 2013 Elsevier Ltd.

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