Tatyana Simuni Feinberg School of Medicine, Feinberg Clinical, Neurology

Tatyana Simuni

    Feinberg School of Medicine
    Feinberg Clinical
    Current Appointments:

    Professor; Neurology; Feinberg School of Medicine

    Arthur C. Nielsen, Jr. Research Professorship in Parkinson's Disease and Movement Disorders; Neurology; Feinberg School of Medicine

Research Interest Keywords

Clinical Trial Methodology, Drug Discovery, Movement Control

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Scopus Publication Detail

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Mobility, mood and site of care impact health related quality of life in Parkinson's disease

J.G. Nutt; A.D. Siderowf; M. Guttman; P.N. Schmidt; J.I. Zamudio; S.S. Wu; M.S. Okun; T. Simuni; S.A. Parashos; N.A. Dahodwala; et al.

(Profiled Author: Tatyana Simuni)

Parkinsonism and Related Disorders. 2014;20(3):274-279.


Objective: Examine the correlates of Health Related Quality of Life (HRQL) in a large cohort of Parkinson's disease (PD) patients from National Parkinson Foundation (NPF) Centers of Excellence (COEs). Background: Improving outcomes for PD will depend upon uncovering disease features impacting HRQL to identify targets for intervention and variables for risk-adjustment models. Differences in HRQL outcomes between COEs could uncover modifiable aspects of care delivery. Methods: This cross-sectional study examined the relative contribution of demographic, social, clinical and treatment features potentially related to HRQL, as measured by the PDQ-39, in 4601 consecutive subjects from 18 COEs. Stepwise linear regression was utilized to identify correlates of HRQL. Results: The variability in the PDQ-39 summary index score correlated with H&Y stage (R2=22%), Timed up and Go (TUG) (17%), disease duration (11%), comorbidities (8%), cognitive status (8%), antidepressant use (6%) and center at which a patient received care (5%). Stepwise regression reordered the importance of the variables, with the H&Y first and TUG and the center becoming equal and the second most important variables determining the PDQ-39 total score. All independent variables together accounted for 44% of the variability in HRQL. Conclusions: We confirmed many but not all HRQL associations found in smaller studies. A novel observation was that the site of care was an important contributor to HRQL, suggesting that comparison of outcomes and processes among centers may identify best practices. © 2013 Elsevier Ltd.

PMID: 24182524    

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