1DPN : B-DODECAMER CGCGAA(TAF)TCGCG WITH INCORPORATED 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINE

  • Martin Egli (Contributor)
  • Valentina Tereshko (Contributor)
  • Marianna Teplova (Contributor)
  • George Minasov (Contributor)
  • Andrzej Joachimiak (Contributor)
  • Ruslan Sanishvili (Contributor)
  • Charles M. Weeks (Contributor)
  • R. Miller (Contributor)
  • Martin A. Maier (Contributor)
  • Haoyun An (Contributor)
  • P. Dan Cook (Contributor)
  • Muthiah Manoharan (Contributor)

Dataset

Description

Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:0.95
Classification:DNA
Release Date:2000-04-04
Deposition Date:1999-12-27
Revision Date:2008-04-27#2011-07-13
Molecular Weight:7459.99
Macromolecule Type:DNA
Residue Count:24
Atom Site Count:574
DOI:10.2210/pdb1dpn/pdb

Abstract:
We have determined single crystal structures of an A-DNA decamer and a B-DNA dodecamer at 0.83 and 0.95 A, respectively. The resolution of the former is the highest reported thus far for any right-handed nucleic acid duplex and the quality of the diffraction data allowed determination of the structure with direct methods. The structures reveal unprecedented details of DNA fine structure and hydration; in particular, we have reexamined the overall hydration of A- and B-form DNA, the distribution of water around phosphate groups, and features of the water structure that may underlie the B to A transition.
Date made available2000
PublisherRCSB-PDB

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