1I8D : CRYSTAL STRUCTURE OF RIBOFLAVIN SYNTHASE

  • D. I. Liao (Contributor)
  • Zdzislaw Wawrzak (Contributor)
  • J. C. Calabrese (Contributor)
  • P. V. Viitanen (Contributor)
  • Douglas B. Jordan (Contributor)

Dataset

Description

Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:2.0
Classification:TRANSFERASE
Release Date:2001-09-19
Deposition Date:2001-03-13
Revision Date:2008-04-27#2011-07-13
Molecular Weight:70418.66
Macromolecule Type:Protein
Residue Count:639
Atom Site Count:4578
DOI:10.2210/pdb1i8d/pdb

Abstract:
Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine to yield riboflavin and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine. The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis. The enzyme is nonexistent in humans and is an attractive target for antimicrobial agents of organisms whose pathogenicity depends on their ability to biosynthesize riboflavin.
Date made available2001
PublisherRCSB-PDB

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