5TZ1 : Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1)

  • Tatiana Y. Hargrove (Contributor)
  • Zdzislaw Wawrzak (Contributor)
  • Galina I. Lepesheva (Contributor)

Dataset

Description

Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:2.0
Classification:OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Release Date:2017-03-15
Deposition Date:2016-11-21
Revision Date:2017-03-22#2017-05-03#2017-11-22
Molecular Weight:115158.14
Macromolecule Type:Protein
Residue Count:980
Atom Site Count:8017
DOI:10.2210/pdb5tz1/pdb

Abstract:
With some advances in modern medicine (such as cancer chemotherapy, broad exposure to antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such as
Date made available2017
PublisherRCSB-PDB

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