A systems approach identifies networks and genes linking sleep and stress: implications for neuropathology

  • Peng Jiang (Contributor)
  • Joseph R. Scarpa (Contributor)
  • Bojan Losic (Contributor)

Dataset

Description

Accession Number: GSE60312

Platform:
GPL17021: Illumina HiSeq 2500 (Mus musculus)

Organism: Mus musculus

Published on 2015-01-08

Summary:
Sleep dysfunction and stress susceptibility are co-morbid complex traits, which often precede and predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multi-level organizations of genetic landscape, candidate genes, and molecular networks associated with 328 stress and sleep traits in a chronically stressed population of 338 (C57BL/6J×A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally and cell-type-specific gene co-regulations important for stress and sleep. Using a composite ranking system, we identified network modules most relevant for 15 independent phenotypic categories, highlighting a mitochondria/synaptic module that links sleep and stress. The key network regulators of this module are overrepresented with genes implicated in neuropsychiatric diseases. Our work suggests the interplay between sleep, stress, and neuropathology emerge from genetic influences on gene expression and their collective organization through complex molecular networks, providing a framework to interrogate the mechanisms underlying sleep, stress susceptibility, and related neuropathology.

Overall Design:
Examination of genomic and transcriptomic networks in a random subset of 100 (B6xA/J)F2 mice modeling the natural spectrum of stress susceptibility.

Contact:
Name: Bojan Losic
Organization: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Deparment: Genetics and Genomics
Address: 1425 Madison Avenue new york NY 10029 USA
Email: bojan.losic@mssm.edu

Organization: GEO
Address: USA
Date made available2015
PublisherGene Expression Omnibus

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