Additional file 1 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

  • Leah K. Cuddy (Northwestern University) (Creator)
  • Alia O. Alia (Creator)
  • Miranda A. Salvo (Creator)
  • Sidhanth Chandra (Creator)
  • Tom Grammatopoulos (Creator)
  • Craig J. Justman (Creator)
  • Peter T. Lansbury (Creator)
  • Joe Mazzulli (Creator)
  • Robert J Vassar (Creator)
  • Peter T. Lansbury (Creator)



Additional file 1: Supplementary Fig. 1. Chronic treatment with FTI LNK-754 reduces amyloid burden in the brains of 5XFAD mice. Confocal immunofluorescence microscopy showing uncropped images from Fig. 1A of brain sections from 5-month-old 5XFAD mice treated with vehicle, LNK-754 or lonafarnib immunostained for Aβ42 (red) and NeuN (blue). Scale bar, 1000 μm
Date made available2022

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