Additional file 13: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

  • Chen Kan (Creator)
  • Na Ding (Creator)
  • Jiazhao Yang (Contributor)
  • Zhenya Tan (Creator)
  • Tammy L. McGuire (Creator)
  • Haimei Lu (Contributor)
  • Keqin Zhang (Contributor)
  • Diana M. Palila Berger (Northwestern University) (Creator)
  • John Kessler (Creator)
  • Lixin Kan (Creator)
  • Chen Kan (Creator)
  • Yang Jiazhao (Contributor)



Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC niche) is composed of niche-dwelling progenitor/stem cells (including at least Tie2-cre, Gli1-creER and Glast-creERT labeled cells) and niche supportive cells (including mast cells, neurites, vasculature and macrophages). The formation of the MSC niche likely initiates the pathological osteogenic cascade, under the co-regulation of BMP and Hh signaling through feedback and non-cell autonomous mechanisms. (TIF 1825 kb)
Date made available2019

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