Additional file 2 of Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

  • Shejuan An (Contributor)
  • Jeannie M. Camarillo (Creator)
  • Tina Y. Huang (Creator)
  • Daphne Li (Creator)
  • Juliette A. Morris (Creator)
  • Madeline A. Zoltek (Creator)
  • Jin Qi (Creator)
  • Mandana Behbahani (Contributor)
  • Madhuri Kambhampati (Creator)
  • Neil L Kelleher (Creator)
  • Javad Nazarian (Creator)
  • Paul M. Thomas (Creator)
  • Amanda M. Saratsis (Northwestern University) (Creator)

Dataset

Description

Additional file 2: S2. Targeted mass spectrometry for histone tail analysis. Overview of study design and analysis of histone tail post-translational modification states in pediatric glioma specimens. Tumor tissue specimens were obtained post-mortem or during the course of treatment. Patient-derived tumor cell lines were established from tissue specimens. Extracted histones were analyzed using targeted mass spectrometry of the histone H3 and H4 N-terminal tail, with quantitation of histone post-translational modifications (me1, me2, me3, ac) and unmodified peptide on lysine (K) residues.
Date made available2020
Publisherfigshare

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