Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer

  • Ugo De Giorgi (Contributor)
  • Michal Mego (Creator)
  • Emanuela Scarpi (Creator)
  • Antonio Giordano (Creator)
  • Mario Giuliano (Creator)
  • Vicente Valero (Creator)
  • Ricardo H. Alvarez (Creator)
  • Naoto Ueno (Creator)
  • Massimo Cristofanilli (Northwestern University) (Creator)
  • J. M. Reuben (Creator)



Background:We retrospectively evaluated the correlation between a baseline measurement of circulating tumor cells (CTCs) and inflammation-based scores in patients with metastatic breast cancer (MBC).Methods:The optimal value of inflammation-based scores as the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) to predict survival was determined and compared with CTC 1 versus 1), tumor subtypes (triple-negative versus HER2– ER+ tumors) and MLR only remained significant.Conclusions:CTC and MLR are predictors of overall survival in MBC. CTC correlates with monocytes, in particular in triple-negative tumors.
Date made available2019
PublisherSAGE Journals

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