Description
Accession Number: GSE60778
Platform:
GPL6887: Illumina MouseWG-6 v2.0 expression beadchip
Organism: Mus musculus
Published on 2014-08-26
Summary:
We provide evidence that the Unc-51-like kinase 1 (ULK1) is phosphorylated and activated during engagement of the Type I IFN receptor. Our studies demonstrate that the function of ULK1 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
Overall Design:
Total RNA was isolated from untreated and IFNβ-treated Ulk1/2+/+ and Ulk1/2-/- mouse embryonic fibroblasts (MEFs). Cells were treated for 6 hours with or without mouse IFNβ (2500 IU/ml).
Contact:
Name: Pawel Lisowski
Organization: Institute of Genetics and Animal Breeding, Polish Academy of Sciences
Deparment: Molecular Biology
Address: Postepu 1 Jastrzebiec Poland
Email: [email protected]
Organization: Illumina Inc.
Address: 9885 Towne Centre Drive San Diego CA 92121 USA
Email: [email protected], [email protected]
Phone: 1 800 809 4566
Web-Link: www.illumina.com
Platform:
GPL6887: Illumina MouseWG-6 v2.0 expression beadchip
Organism: Mus musculus
Published on 2014-08-26
Summary:
We provide evidence that the Unc-51-like kinase 1 (ULK1) is phosphorylated and activated during engagement of the Type I IFN receptor. Our studies demonstrate that the function of ULK1 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
Overall Design:
Total RNA was isolated from untreated and IFNβ-treated Ulk1/2+/+ and Ulk1/2-/- mouse embryonic fibroblasts (MEFs). Cells were treated for 6 hours with or without mouse IFNβ (2500 IU/ml).
Contact:
Name: Pawel Lisowski
Organization: Institute of Genetics and Animal Breeding, Polish Academy of Sciences
Deparment: Molecular Biology
Address: Postepu 1 Jastrzebiec Poland
Email: [email protected]
Organization: Illumina Inc.
Address: 9885 Towne Centre Drive San Diego CA 92121 USA
Email: [email protected], [email protected]
Phone: 1 800 809 4566
Web-Link: www.illumina.com
| Date made available | Aug 26 2014 |
|---|---|
| Publisher | Gene Expression Omnibus |