Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598

Tatiana Y. Hargrove (Contributor)
Edward P. Garvey (Contributor)
William J. Hoekstra (Contributor)
Christopher M. Yates (Contributor)
Zdzislaw Wawrzak (Contributor)
Girish Rachakonda (Contributor)
Fernando Villalta (Contributor)
Galina I. Lepesheva (Contributor)

Northwestern University

Dataset

Date made available	Apr 26 2017
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb5FRB/pdb

Access Dataset

https://www.wwpdb.org/pdb?id=pdb_00005frb

1 Article

Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity
Hargrove, T. Y., Garvey, E. P., Hoekstra, W. J., Yates, C. M., Wawrzak, Z., Rachakonda, G., Villalta, F. & Lepesheva, G. I., Jul 2017, In: Antimicrobial agents and chemotherapy. 61, 7, e00570-17.
Research output: Contribution to journal › Article › peer-review

Open Access
56 Scopus citations

Cite this

Hargrove, T. Y. (Contributor), Garvey, E. P. (Contributor), Hoekstra, W. J. (Contributor), Yates, C. M. (Contributor), Wawrzak, Z. (Contributor), Rachakonda, G. (Contributor), Villalta, F. (Contributor), Lepesheva, G. I. (Contributor) (Apr 26 2017). Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598. Protein Data Bank (PDB). 10.2210/pdb5FRB/pdb

Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598

DOI

Access Dataset

Research output

Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity

Cite this