Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598

Tatiana Y. Hargrove (Contributor)
Edward P. Garvey (Contributor)
William J. Hoekstra (Contributor)
Christopher M. Yates (Contributor)
Zdzislaw Wawrzak (Contributor)
Girish Rachakonda (Contributor)
Fernando Villalta (Contributor)
Galina I. Lepesheva (Contributor)

Northwestern University

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2017
Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity
Hargrove, T. Y., Garvey, E. P., Hoekstra, W. J., Yates, C. M., Wawrzak, Z., Rachakonda, G., Villalta, F. & Lepesheva, G. I., Jul 2017, In: Antimicrobial agents and chemotherapy. 61, 7, e00570-17.
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Open Access
56 Scopus citations