Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi

Tatiana Y. Hargrove (Contributor)
Zdzislaw Wawrzak (Contributor)
Paxtyn M. Fisher (Contributor)
Stella A. Child (Contributor)
W. David Nes (Contributor)
F. Peter Guengerich (Contributor)
Michael R. Waterman (Contributor)
Galina I. Lepesheva (Contributor)

Northwestern University

Dataset

Date made available	Oct 24 2018
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb6FMO/pdb

Access Dataset

https://www.wwpdb.org/pdb?id=pdb_00006fmo

1 Article

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51
Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Dec 14 2018, In: Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
20 Scopus citations

Cite this

Hargrove, T. Y. (Contributor), Wawrzak, Z. (Contributor), Fisher, P. M. (Contributor), Child, S. A. (Contributor), David Nes, N. W. (Contributor), Peter Guengerich, G. F. (Contributor), Waterman, M. R. (Contributor), Lepesheva, G. I. (Contributor) (Oct 24 2018). Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi. Protein Data Bank (PDB). 10.2210/pdb6FMO/pdb

Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi

DOI

Access Dataset

Research output

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Cite this