Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi

Tatiana Y. Hargrove (Contributor)
Zdzislaw Wawrzak (Contributor)
Paxtyn M. Fisher (Contributor)
Stella A. Child (Contributor)
W. David Nes (Contributor)
F. Peter Guengerich (Contributor)
Michael R. Waterman (Contributor)
Galina I. Lepesheva (Contributor)

Northwestern University

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2018
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51
Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Dec 14 2018, In: Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
20 Scopus citations