Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

  • Emily R. Holzinger (Creator)
  • Shefali S. Verma (Creator)
  • Carrie B. Moore (Creator)
  • Molly A. Hall (Creator)
  • Rishika De (Contributor)
  • Diane Gilbert-Diamond (Creator)
  • Matthew B. Lanktree (Creator)
  • Nathan Pankratz (Creator)
  • Antoinette Amuzu (Creator)
  • Amber A. Burt (Creator)
  • Caroline E. Dale (Creator)
  • Scott Dudek (Creator)
  • Clement E. Furlong (Creator)
  • Tom R. Gaunt (Creator)
  • Daniel Seung Kim (Creator)
  • Helene Riess (Creator)
  • Suthesh Sivapalaratnam (Contributor)
  • Vinicius Tragante (Creator)
  • Erik P A Van Iperen (Contributor)
  • A. Brautbar (Creator)
  • David S. Carrell (Creator)
  • David R. Crosslin (Creator)
  • Gail P. Jarvik (Creator)
  • Helena Kuivaniemi (Creator)
  • Iftikhar J. Kullo (Creator)
  • Eric B. Larson (Creator)
  • Laura J Rasmussen-Torvik (Creator)
  • Gerard Tromp (Creator)
  • Jens Baumert (Creator)
  • Karen J. Cruickshanks (Creator)
  • Martin Farrall (Creator)
  • Aroon D. Hingorani (Contributor)
  • G. Kees Hovingh (Contributor)
  • Marcus E. Kleber (Creator)
  • Barbara E. Klein (Creator)
  • Ronald Klein (Creator)
  • Wolfgang Koenig (Creator)
  • Leslie Lange (Creator)
  • Winfried MOrz (Contributor)
  • Kari E. North (Creator)
  • N. Charlotte Onland-Moret (Contributor)
  • Alexander P. Reiner (Creator)
  • Philippa J. Talmud (Creator)
  • Yvonne T. Van Der Schouw (Contributor)
  • James G. Wilson (Creator)
  • Mika Kivimaki (Creator)
  • Meena Kumari (Creator)
  • Jason H. Moore (Creator)
  • Fotios Drenos (Creator)
  • Folkert W. Asselbergs (Creator)
  • Brendan Keating (Creator)
  • Marylyn D. Ritchie (Creator)

Dataset

Description

Abstract Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Results Our analysis consisted of a discovery phase using a merged dataset of five different cohorts (n = 12,853 to n = 16,849 depending on lipid phenotype) and a replication phase with ten independent cohorts totaling up to 36,938 additional samples. Filters are often applied before interaction testing to correct for the burden of testing all pairwise interactions. We used two different filters: 1. A filter that tested only single nucleotide polymorphisms (SNPs) with a main effect of p
Date made available2017
Publisherfigshare

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  • Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

    Holzinger, E. R., Verma, S. S., Moore, C. B., Hall, M., De, R., Gilbert-Diamond, D., Lanktree, M. B., Pankratz, N., Amuzu, A., Burt, A., Dale, C., Dudek, S., Furlong, C. E., Gaunt, T. R., Kim, D. S., Riess, H., Sivapalaratnam, S., Tragante, V., Van Iperen, E. P. A., Brautbar, A., & 32 othersCarrell, D. S., Crosslin, D. R., Jarvik, G. P., Kuivaniemi, H., Kullo, I. J., Larson, E. B., Rasmussen-Torvik, L. J., Tromp, G., Baumert, J., Cruickshanks, K. J., Farrall, M., Hingorani, A. D., Hovingh, G. K., Kleber, M. E., Klein, B. E., Klein, R., Koenig, W., Lange, L. A., MOrz, W., North, K. E., Charlotte Onland-Moret, N., Reiner, A. P., Talmud, P. J., Van Der Schouw, Y. T., Wilson, J. G., Kivimaki, M., Kumari, M., Moore, J. H., Drenos, F., Asselbergs, F. W., Keating, B. J. & Ritchie, M. D., Jul 24 2017, In: BioData Mining. 10, 1, 25.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

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