DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

  • Pamela R. Matías-García (Creator)
  • Cavin K. Ward-Caviness (Creator)
  • Laura Raffield (Creator)
  • Xu Gao (Creator)
  • Yan Zhang (Creator)
  • Rory Wilson (Creator)
  • Xīn Gào (Creator)
  • Jana Nano (Creator)
  • Andrew Bostom (Creator)
  • Elena Colicino (Creator)
  • Adolfo Correa (Creator)
  • Brent A. Coull (Creator)
  • Charles B. Eaton (Creator)
  • Lifang Hou (Creator)
  • Allan Just (Creator)
  • Sonja Kunze (Creator)
  • Leslie A. Lange (Creator)
  • Ethan M. Lange (Creator)
  • Xihong Lin (Creator)
  • Simin Liu (Creator)
  • Jamaji C. Nwanaji-Enwerem (Creator)
  • Alexander P. Reiner (Creator)
  • Jincheng Shen (Creator)
  • Ben Schöttker (Creator)
  • Pantel S. Vokonas (Creator)
  • Yinan Zheng (Creator)
  • Bessie Young (Creator)
  • Joel Schwartz (Creator)
  • S. Horvath (Creator)
  • Ake T. Lu (Creator)
  • Eric A. Whitsel (Creator)
  • Wolfgang Koenig (Creator)
  • Jerzy Adamski (Creator)
  • Juliane Winkelmann (Creator)
  • Hermann Brenner (Creator)
  • Andrea A. Baccarelli (Creator)
  • Christian Gieger (Creator)
  • Annette Peters (Creator)
  • Nora Franceschini (Creator)
  • Melanie Waldenberger (Creator)
  • Adolfo Correa (Creator)
  • Brent Coull (Creator)
  • Ethan Lange (Creator)
  • Xihong Lin (Creator)
  • Ben Schöttker (Creator)
  • Steve Horvath (Creator)
  • Ake T. Lu (Creator)
  • Andrea A. Baccarelli (Creator)
  • Christian Gieger (Creator)
  • Annette Peters (Creator)
  • N. Franceschini (Creator)



Abstract Background The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morbidity and mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations between seven DNAm aging and lifespan predictors (as well as GrimAge components) and five kidney traits (estimated glomerular filtration rate [eGFR], urine albumin-to-creatinine ratio [uACR], serum urate, microalbuminuria and chronic kidney disease [CKD]) in up to 9688 European, African American and Hispanic/Latino individuals from seven population-based studies. Results We identified 23 significant associations in our large trans-ethnic meta-analysis (p
Date made available2021
  • DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

    Matías-García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gào, X., Nano, J., Bostom, A., Colicino, E., Correa, A., Coull, B., Eaton, C., Hou, L., Just, A. C., Kunze, S., Lange, L., Lange, E., Lin, X., Liu, S., & 20 othersNwanaji-Enwerem, J. C., Reiner, A., Shen, J., Schöttker, B., Vokonas, P., Zheng, Y., Young, B., Schwartz, J., Horvath, S., Lu, A., Whitsel, E. A., Koenig, W., Adamski, J., Winkelmann, J., Brenner, H., Baccarelli, A. A., Gieger, C., Peters, A., Franceschini, N. & Waldenberger, M., Dec 2021, In: Clinical Epigenetics. 13, 1, 121.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations

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