Human Ornithine Aminotransferase cocrystallized with its inhibitor, (S,E)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate

Wei Zhu (Contributor)
Arseniy Butrin (Contributor)
Rafael D. Melani (Contributor)
Peter F. Doubleday (Contributor)
Glaucio M. Ferreira (Contributor)
Maurício T. Tavares (Contributor)
Thahani S. Habeeb Mohammad (Contributor)
Brett A. Beaupre (Contributor)
Neil L Kelleher (Contributor)
Graham R. Moran (Contributor)
Dali Liu (Contributor)
Richard B Silverman (Contributor)

Dataset

Date made available	Apr 6 2022
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb7TED/pdb

Access Dataset

https://www.wwpdb.org/pdb?id=pdb_00007ted

1 Article

Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase
Zhu, W., Butrin, A., Melani, R. D., Doubleday, P. F., Ferreira, G. M., Tavares, M. T., Habeeb Mohammad, T. S., Beaupre, B. A., Kelleher, N. L., Moran, G. R., Liu, D. & Silverman, R. B., Mar 30 2022, In: Journal of the American Chemical Society. 144, 12, p. 5629-5642 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Scopus citations

Cite this

Zhu, W. (Contributor), Butrin, A. (Contributor), Melani, R. D. (Contributor), Doubleday, P. F. (Contributor), Ferreira, G. M. (Contributor), Tavares, M. T. (Contributor), Habeeb Mohammad, T. S. (Contributor), Beaupre, B. A. (Contributor), Kelleher, N. L. (Contributor), Moran, G. R. (Contributor), Liu, D. (Contributor), Silverman, R. B. (Contributor) (Apr 6 2022). Human Ornithine Aminotransferase cocrystallized with its inhibitor, (S,E)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate. Protein Data Bank (PDB). 10.2210/pdb7TED/pdb

Human Ornithine Aminotransferase cocrystallized with its inhibitor, (S,E)-3-amino-4-(fluoromethylene)cyclopent-1-ene-1-carboxylate

DOI

Access Dataset

Research output

Rational Design, Synthesis, and Mechanism of (3 S,4 R)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase

Cite this