Human sterol 14a-demethylase (CYP51) in complex with the functionally irreversible inhibitor (R)-N-(1-(3-chloro-4'-fluoro-[1,1'-biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(3-fluoro-5-(5-fluoropyrimidin-4-yl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide

Laura Friggeri (Contributor)
Tatiana Y. Hargrove (Contributor)
Zdzislaw Wawrzak (Contributor)
F. Peter Guengerich (Contributor)
Galina I. Lepesheva (Contributor)

Northwestern University

Dataset

Date made available	Nov 13 2019
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb6Q2T/pdb

Access Dataset

https://www.wwpdb.org/pdb?id=pdb_00006q2t

1 Article

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors
Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Guengerich, F. P. & Lepesheva, G. I., Nov 27 2019, In: Journal of Medicinal Chemistry. 62, 22, p. 10391-10401 11 p.
Research output: Contribution to journal › Article › peer-review
24 Scopus citations

Cite this

Friggeri, L. (Contributor), Hargrove, T. Y. (Contributor), Wawrzak, Z. (Contributor), Guengerich, F. P. (Contributor), Lepesheva, G. I. (Contributor) (Nov 13 2019). Human sterol 14a-demethylase (CYP51) in complex with the functionally irreversible inhibitor (R)-N-(1-(3-chloro-4'-fluoro-[1,1'-biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(3-fluoro-5-(5-fluoropyrimidin-4-yl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide. Protein Data Bank (PDB). 10.2210/pdb6Q2T/pdb

Human sterol 14a-demethylase (CYP51) in complex with the functionally irreversible inhibitor (R)-N-(1-(3-chloro-4'-fluoro-[1,1'-biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(3-fluoro-5-(5-fluoropyrimidin-4-yl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide

DOI

Access Dataset

Research output

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

Cite this