Metadata record for the manuscript: Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

SummaryThe data described in this metadata record underlie the findings of the related manuscript, which evaluated whether a recently developed polygenic risk score (PRS) based on 313-common variants for breast cancer prediction is related to terminal duct lobular unit (TDLU) involution in the background, normal breast tissue, as this could provide mechanistic clues on the genetic predisposition to breast cancer. Data accessThe PRS data are in the R file ‘BC.impute.313.Rdata’. The BREAST Stamp Project data are not publicly available because the informed consent signed by the patients did not include public data sharing. However, these data are available through the Susan G. Komen Tissue Bank (KTB)’s virtual repository (http://virtualtissuebank.iu.edu). To request these data, contact Dr. Gretchen Gierach ([email protected]). The phenotype and polygenic risk scores are available from the dbGaP repository under the following accession ID: https://identifiers.org/dbgap:phs002062.v1.p1 Data contact detailsDr. Gretchen Gierach National Cancer Institute Division of Cancer Epidemiology and Genetics Bethesda, MD 20892 United States [email protected] Name of Institutional Review Board or ethics committee that approved the studyApproval for this study was obtained from the Indiana University Institutional Review Board (IRB) and the National Institutes of Health Office of Human Subjects Research (NIH OHSR #4508).