MOESM4 of Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

  • Sarah H. White (Creator)
  • Mary M McDermott (Creator)
  • Robert L Sufit (Creator)
  • Kate Kosmac (Creator)
  • Alex W. Bugg (Creator)
  • Marta Gonzalez-Freire (Creator)
  • Luigi Ferrucci (Creator)
  • Lu Tian (Creator)
  • Lihui Zhao (Contributor)
  • Ying Gao (Creator)
  • Melina R. Kibbe (Department of Veterans Affairs, Northwestern University) (Creator)
  • Michael H. Criqui (Creator)
  • Christiaan Leeuwenburgh (Creator)
  • Charlotte A. Peterson (Creator)
  • Mary M. McDermott (Creator)
  • Luigi Ferrucci (Creator)
  • Michael H. Criqui (Creator)



Additional file 4: Figure S4. Lectin staining to quantify capillary density. Representative images of lectin binding to endothelial cells in non-PAD (A) and PAD (B) gastrocnemius muscle sections. C) Quantification of lectin staining, expressed as lectin+ capillaries/fiber in PAD (n=18) compared to non-PAD (n=7) participants (ANOVA, P=0.082). Approximately 600 fibers were analyzed per subject. Data represented as Mean Âą SEM. Scale bar = 50 Âľm.
Date made available2016

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