Rhabdoid Tumor: Gene Expression Clues to Pathogenesis and Potential Therapeutic Targets



Accession Number: GSE11482

GPL96: [HG-U133A] Affymetrix Human Genome U133A Array

Organism: Homo sapiens

Published on 2010-02-28

Rhabdoid tumors (RT) are aggressive tumors characterized by genetic loss of SMARCB1 (SNF5, INI-1), a component of the SWI/SNF chromatin remodeling complex. No effective treatment is currently available. This study seeks to shed light on the SMARCB1-mediated pathogenesis of RT and to discover potential therapeutic targets. Global gene expression of 10 RT was compared with 12 cellular mesoblastic nephromas, 16 clear cell sarcomas of the kidney, and 15 Wilms tumors. 114 top genes were differentially expressed in RT (p2 or
Date made available2010
PublisherGene Expression Omnibus

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