Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.

Jon Jacobs (Contributor)
Valerie Grum-Tokars (Contributor)
Ya Zhou (Contributor)
Mark Turlington (Contributor)
S. Adrian Saldanha (Contributor)
Peter Chase (Contributor)
Aimee Eggler (Contributor)
Eric S. Dawson (Contributor)
Yahira M. Baez-Santos (Contributor)
Sakshi Tomar (Contributor)
Anna M. Mielech (Contributor)
S. C. Baker (Contributor)
Craig W. Lindsley (Contributor)
Peter Hodder (Contributor)
Andrew D. Mesecar (Contributor)
Shaun R. Stauffer (Contributor)

Dataset

Date made available	Jan 16 2013
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb3V3M/pdb

Access Dataset

https://www.wwpdb.org/pdb?id=pdb_00003v3m

1 Article

Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A. & Stauffer, S. R., Jan 24 2013, In: Journal of Medicinal Chemistry. 56, 2, p. 534-546 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
173 Scopus citations

Cite this

Jacobs, J. (Contributor), Grum-Tokars, V. (Contributor), Zhou, Y. (Contributor), Turlington, M. (Contributor), Saldanha, S. A. (Contributor), Chase, P. (Contributor), Eggler, A. (Contributor), Dawson, E. S. (Contributor), Baez-Santos, Y. M. (Contributor), Tomar, S. (Contributor), Mielech, A. M. (Contributor), Baker, S. C. (Contributor), Lindsley, C. W. (Contributor), Hodder, P. (Contributor), Mesecar, A. (Contributor), Stauffer, S. R. (Contributor) (Jan 16 2013). Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor. Protein Data Bank (PDB). 10.2210/pdb3V3M/pdb

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.

DOI

Access Dataset

Research output

Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

Cite this