Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

  • Paula Whitmire (Creator)
  • Cassandra R. Rickertsen (Creator)
  • A. Hawkins-Daarud (Creator)
  • Eduardo Carrasco (Creator)
  • Julia Lorence (Creator)
  • Gustavo De Leon (Contributor)
  • Lee Curtin (Creator)
  • Spencer Bayless (Creator)
  • Kamala Clark-Swanson (Creator)
  • Noah C. Peeri (Creator)
  • Christina Corpuz (Creator)
  • C. Paula Lewis-de los Angeles (Contributor)
  • Bernard R. Bendok (Creator)
  • Luis F. Gonzalez-Cuyar (Creator)
  • Sujay Vora (Contributor)
  • Maciej Mrugala (Creator)
  • Leland S. Hu (Creator)
  • Lei Wang (Creator)
  • Alyx B. Porter (Contributor)
  • Priya U Kumthekar (Creator)
  • Sandra K. Johnston (Creator)
  • Kathleen M. Egan (Creator)
  • Robert A. Gatenby (Creator)
  • Peter Canoll (Creator)
  • Joshua B. Rubin (Creator)
  • Kristin R. Swanson (Creator)
  • Gustavo De Leon (Creator)
  • Maciej M. Mrugala (Creator)
  • Robert Gatenby (Creator)

Dataset

Description

Abstract Background Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p
Date made available2020
Publisherfigshare
  • Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

    Whitmire, P., Rickertsen, C. R., Hawkins-Daarud, A., Carrasco, E., Lorence, J., De Leon, G., Curtin, L., Bayless, S., Clark-Swanson, K., Peeri, N. C., Corpuz, C., Lewis-De Los Angeles, C. P., Bendok, B. R., Gonzalez-Cuyar, L., Vora, S., Mrugala, M. M., Hu, L. S., Wang, L., Porter, A., Kumthekar, P., & 6 othersJohnston, S. K., Egan, K. M., Gatenby, R., Canoll, P., Rubin, J. B. & Swanson, K. R., May 19 2020, In: BMC cancer. 20, 1, 447.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations

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