Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]

Galina I. Lepesheva (Contributor)
Tatiana Y. Hargrove (Contributor)
Girish Rachakonda (Contributor)
Zdzislaw Wawrzak (Contributor)
Sébastien Pomel (Contributor)
Sandrine Cojean (Contributor)
Pius N. Nde (Contributor)
W. David Nes (Contributor)
Charles W. Locuson (Contributor)
M. Wade Calcutt (Contributor)
Michael R. Waterman (Contributor)
J. Scott Daniels (Contributor)
Philippe M. Loiseau (Contributor)
Fernando Villalta (Contributor)

Northwestern University

Dataset

Date made available	Jul 17 2013
Publisher	Protein Data Bank (PDB)

DOI
10.2210/pdb4G3J/pdb

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https://www.wwpdb.org/pdb?id=pdb_00004g3j

1 Article

VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis
Lepesheva, G. I., Hargrove, T. Y., Rachakonda, G., Wawrzak, Z., Pomel, S., Cojean, S., Nde, P. N., Nes, W. D., Locuson, C. W., Calcutt, M. W., Waterman, M. R., Daniels, J. S., Loiseau, P. M. & Villalta, F., Nov 1 2015, In: Journal of Infectious Diseases. 212, 9, p. 1439-1448 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
55 Scopus citations

Cite this

Lepesheva, G. I. (Contributor), Hargrove, T. Y. (Contributor), Rachakonda, G. (Contributor), Wawrzak, Z. (Contributor), Pomel, S. (Contributor), Cojean, S. (Contributor), Nde, P. N. (Contributor), Nes, W. D. (Contributor), Locuson, C. W. (Contributor), Calcutt, M. W. (Contributor), Waterman, M. R. (Contributor), Daniels, J. S. (Contributor), Loiseau, P. M. (Contributor), Villalta, F. (Contributor) (Jul 17 2013). Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]. Protein Data Bank (PDB). 10.2210/pdb4G3J/pdb

Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)]

DOI

Access Dataset

Research output

VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis

Cite this