Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a-K1422E mice

Strain-dependent effects on neurobehavioral and seizure phenotypes in Scn2a K1422E mice All data reported in the above entitled manuscript are contained in this workbook. Contents: Sheet 1: Zero Maze Raw data for all subjects evaluated using the zero maze assay Subjects are identified by study number in column A Sex information (M, F) is given in column B Strain information (B6, F1D2) is given in column C Genotype information (WT, E/+) is given in column D Time spent in open arms (% of total trial time, 5 minutes) is given in column E Total distance traveled (cm) is given in column F ***rows in red indicate subjects that exited the maze and were excluded*** Sheet 2: Open Field Raw data for all subjects evaluated using the open field assay Subjects are identified by study number in column A Sex information (M, F) is given in column B Strain information (B6, F1D2) is given in column C Genotype information (WT, E/+) is given in column D Time spent in center zone (% of total trial time, 10 minutes) is given in column E Total distance traveled (cm) is given in column F Sheet 3: Kainic Acid Seizure Induction: Binned Raw data reflecting highest seizure stage reached within 5 minute bins for all subjects following kainic acid administration Subjects are identified by study number in column A Sex information (M, F) is given in column B Strain information (B6, F1D2) is given in column C Genotype information (WT, E/+) is given in column D Highest seizure stage (1-7) reached per 5 min time bin is given in columns E-AB ***For columns E-AB, after a subject reaches stage 7 (death) all subsequent bins are scored as 7*** Legend for modified Racine scale stages is given in columns AD-AE Sheet 4: Kainic Acid Seizure Induction: Latency Raw data reflecting latency to first occurrence of each seizure stage for all subjects following kainic acid administration Subjects are identified by study number in column A Sex information (M, F) is given in column B Strain information (B6, F1D2) is given in column C Genotype information (WT, E/+) is given in column D Latency (min) to each seizure stage is given in columns E-K ***For columns E-K, a dash (-) indicates a subject did not reach that seizure stage in the 120 min trial period*** Legend for modified Racine scale stages is given in columns M-N ***rows in red indicate subjects that died shortly after the 120 min trial period***