Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial

  • Joshua T. Slysz (Creator)
  • W. Jack Rejeski (Contributor)
  • Diane Treat-Jacobson (Creator)
  • Lydia A. Bazzano (Creator)
  • Daniel E. Forman (Creator)
  • Todd M. Manini (Creator)
  • Michael H. Criqui (Creator)
  • Lu Tian (Creator)
  • Lihui Zhao (Contributor)
  • Dongxue Zhang (Contributor)
  • Jack M. Guralnik (Creator)
  • Luigi Ferrucci (Creator)
  • Melina R Kibbe (University of North Carolina at Chapel Hill) (Creator)
  • Tamar S. Polonsky (Creator)
  • Bonnie Spring (Creator)
  • Robert L Sufit (Creator)
  • Christiaan Leeuwenburgh (Creator)
  • Mary M McDermott (Creator)
  • Todd M. Manini (Creator)
  • Zhang Dongxue (Contributor)
  • Jack M. Guralnik (Creator)
  • Luigi Ferrucci (Creator)
  • Christiaan Leeuwenburgh (Creator)
  • Mary M. McDermott (Creator)



This study investigated cross-sectional associations of peripheral artery disease (PAD) severity (defined by the ankle–brachial index (ABI)) and amounts of daily sustained physical activity (PA) (defined as > 100 activity counts per minute lasting 5 consecutive minutes or more). This study also investigated associations of amounts of daily sustained PA with 6-minute walk (6MW) distance and the Short Form-36 physical functioning domain (SF-36 PF) score in cross-sectional analyses and with serious adverse events (SAEs) in longitudinal analyses of people with PAD. PA was measured continuously for 10 days using a tri-axial accelerometer at baseline in 277 participants with PAD randomized to the LITE clinical trial. In regression analyses, each 0.15 lower ABI value was associated with a 5.67% decrease in the number of daily bouts of sustained PA (95% CI: 3.85–6.54; p < 0.001). Every additional bout of sustained PA per day was associated with a 4.56-meter greater 6MW distance (95% CI: 2.67–6.46; p < 0.0001), and a 0.81-point improvement in SF-36 PF score (95% CI: 0.34–1.28; p < 0.001). Participants with values of daily bouts of sustained PA below the median had higher rates of SAEs during follow-up, compared to participants above the median (41% vs 24%; p = 0.002). In conclusion, among participants with PAD, lower ABI values were associated with fewer bouts of daily sustained PA. A greater number of bouts of daily sustained PA were associated with better 6MW performance and SF-36 PF score, and, in longitudinal analyses, lower rates of SAEs. ID: NCT02538900.
Date made available2021
PublisherSAGE Journals

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