Transcription profiling of mouse model of amyotrophic lateral sclerosis (ALS) vs. wild type

  • Thomas J. Lukas (Contributor)
  • Wei Wei Luo (Contributor)
  • Haihong Mao (Contributor)
  • Natalie Cole (Contributor)
  • Teepu Siddique (Contributor)



mRNA expression in the spinal cords of the G93A-SOD1 familial ALS transgenic mouse model was compared to that in nontransgenic (Normal mouse) and transgenic mice expressing wild-type (WT)SOD1. Gene Ontology (GO)analysis was used to characterize differences in expression between G93A-SOD1 mouse and nontransgenic mouse spinal cord. Changes in multiple GO categories were found. Many of these were associated with subsystems involving cell-cell communication and intracellular signal transduction. Expression profiles of mice expressing WT-SOD1 did not differ from nontransgenic mice. In contrast, protein profiling using proteomics technology indicated changes in mitochondrial protein expression in the G93A-SOD1 mouse spinal cord that were not found in the mRNA expression analysis.
Date made available2007

Cite this