Transcription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu

  • Dipankar Ray (Contributor)
  • Yasuhisa Terao (Contributor)
  • Peter G. Fuhrken (Contributor)
  • Zhi Qing Ma (Contributor)
  • Francesco J. DeMayo (Contributor)
  • Konstantin Christov (Contributor)
  • Nyla A. Heerema (Contributor)
  • R. Franks (Contributor)
  • Sophia Y. Tsai (Contributor)
  • E. Terry Papoutsakis (Contributor)
  • Hiroaki Kiyokawa (Contributor)



CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumorigenesis induced by expression of ras or neu. CDC25A- overexpressing tumors display aggressiveness and genomic instability with changes in fragile chromosomal regions, including the region orthologous to human 1p32-36. Experiment Overall Design: Tumors from two mice from each of two conditions (MMTV-cdc25a;MMTV-neu and MMTV-neu) were analyzed in a dye swap experiment. A total of four hybridizations were performed.
Date made available2008

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