Transcriptome analyses of skeletal muscle in αB-crystallin/HspB2 knockout and wild-type mice on a normal or high fat diet

  • Daniel J. Toft (Northwestern University) (Contributor)
  • Brian T. Layden (Department of Veterans Affairs, Northwestern University) (Contributor)



Accession Number: GSE66557

GPL13112: Illumina HiSeq 2000 (Mus musculus)

Organism: Mus musculus

Published on 2015-09-01

We profiled the skeletal muscle transcriptome between wild type and αB-crystallin/HspB2 knock mice exposed to normal chow and high fat diets to examine the role of αB-crystallin/HspB2 in diet induced obesity. Combined with metabolic profiling of the mice, these data reveal that αB-crystallin/HspB2 is involved in the genesis of insulin resistance on a high fat diet, and we provide extensive RNA profiling to illuminate potential mechanistic insights into the muscle-specific role of αB-crystallin/HspB2.

Overall Design:
Hind limb muscle mRNA profiles of wild type and αB-crystallin/HspB2 knock mice exposed to either normal chow or high fat diets using RNAseq analysis

Name: Daniel Toft
Organization: Northwestern University
Deparment: Endocrinology
Address: 675 N. St. Clair Street, 14-100 Chicago IL 60611 USA

Organization: GEO
Address: USA
Date made availableMar 5 2015
PublisherGene Expression Omnibus

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