The mission of the Clinical Pharmacology Core Facility is to provide state-of-the-art clinical pharmacologic support to Northwestern University investigators as an integral part of bench-to-bedside drug development. The Clinical Pharmacology Core provides pharmacokinetic support for preclinical and clinical studies of cancer chemotherapeutic agents, analgesics, and other small molecules. Expertise includes optimizing the design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies. Small molecule concentrations in plasma and other body fluids are measured using an Agilent HPLC system linked to an Applied Biosystems API 3000 triple quadrupole mass spectrometer. Drug concentration histories are fitted to various compartmental pharmacokinetic models using commercially available and specialized software.
High Pressure Liquid Chromatography
- 6500 QTrap Mass Spectrometer