Developmental Therapeutics Core

Equipment/facility: Facility

Description

The Developmental Therapeutics Core (DTC), under the umbrella of the Center for Developmental Therapeutics (CDT), provides services focused on supporting the translation of new therapeutics to the clinic. The DTC supports grant applications and can act as an already established translational Core on multi-investigator U and P type grants. In addition to supporting basic research leading to drug translation, the DTC also provides support to clinical investigators interested in advancing new compounds into clinical trials including drug assessment and clinical protocol support. For more information on this facility click here.

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Clinical Protocols
Clinical Trials

Categories

  • Animal Preclinical Services

Resources

  • Xenograft models (including drug efficacy/dose ranging)
  • In vivo imaging
  • Pharmacokinetics
  • Toxicology (NOAEL/MTD)
  • Drug uptake (in vitro)
  • Proliferation assay (NCI60/NUTS panels)
  • Cancer cell lines
  • Migration/invasion assays (include metastasis and wound healing)
  • Drug (small molecules and biologics) formulation
  • Clinical protocol support
  • Toxicology
  • Patient Derived Xenograft (PDX)
  • Histology slide analysis
  • Animal preclinical services