CLP - Developmental Therapeutics Core (DTC)

Research Output

Article

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2

Sheppard, G. S., Wang, J., Kawai, M., BaMaung, N. Y., Craig, R. A., Erickson, S. A., Lynch, L., Patel, J., Yang, F., Searle, X. B., Lou, P., Park, C., Kim, K. H., Henkin, J. & Lesniewski, R., Feb 23 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 4, p. 865-868 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib

Liu, Y., Lou, G., Norton, J. T., Wang, C., Kandela, I., Tang, S., Shank, N. I., Gupta, P., Huang, M., Avram, M. J., Green, R., Mazar, A., Appella, D., Chen, Z. & Huang, S., 2017, In : FASEB Journal. 31, 12, p. 5453-5465 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

ABT-510, a modified type 1 repeat peptide of thrombospondin, inhibits malignant glioma growth in vivo by inhibiting angiogenesis

Anderson, J. C., Grammer, J. R., Wang, W., Nabors, L. B., Henkin, J., Stewart, J. E. & Gladson, C. L., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 454-462 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer

Greenaway, J., Henkin, J., Lawler, J., Moorehead, R. & Petrik, J., Jan 1 2009, In : Molecular cancer therapeutics. 8, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

ABT-898 induces tumor regression and prolongs survival in a mouse model of epithelial ovarian cancer

Campbell, N., Greenaway, J., Henkin, J. & Petrik, J., Oct 1 2011, In : Molecular cancer therapeutics. 10, 10, p. 1876-1885 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

A-chain isozymes of recombinant and natural urokinases: Preparation, characterization, and their biochemical and fibrinolytic properties

Marcotte, P. A., Henkin, J., Credo, R. B. & Badylak, S. F., Apr 1992, In : Fibrinolysis and Proteolysis. 6, 2, p. 69-78 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A chromogenic enzymatic assay capable of detecting prourokinase-like material in plasma

Kebabian, P. R. & Henkin, J., Feb 1 1992, In : Thrombosis Research. 65, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Affinity labeling of dihydrofolate reductase with an antifolate glyoxal

Henkin, J. & Johanson, R. A., Jan 1 1984, In : Federation Proceedings. 43, 7

Research output: Contribution to journalArticle

Affinity labeling of dihydrofolate reductase with an antifolate glyoxal

Johanson, R. A. & Henkin, J., Jan 1 1985, In : Journal of Biological Chemistry. 260, 3, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy

Weichert, J. P., Clark, P. A., Kandela, I. K., Vaccaro, A. M., Clarke, W., Longino, M. A., Pinchuk, A. N., Farhoud, M., Swanson, K. I., Floberg, J. M., Grudzinski, J., Titz, B., Traynor, A. M., Chen, H. E., Hall, L. T., Pazoles, C. J., Pickhardt, P. J. & Kuo, J. S., Jun 11 2014, In : Science translational medicine. 6, 240, 240ra75.

Research output: Contribution to journalArticle

51 Scopus citations

An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells

Rabbani, S. A., Desjardins, J., Bell, A. W., Banville, D., Mazar, A., Henkin, J. & Goltzman, D., Dec 31 1990, In : Biochemical and Biophysical Research Communications. 173, 3, p. 1058-1064 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Anthranilate synthase of Neurospora crassa: Reaction and labeling with glutamine analogs

Paukert, J. L., Henkin, J., Keesey, J. & Demoss, J. A., Oct 15 1982, In : Archives of biochemistry and biophysics. 218, 2, p. 443-449 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: Combined in vitro and in silico investigations

Zhong, Z., Zhang, Q., Tao, H., Sang, W., Cui, L., Qiang, W., Cheang, W. S., Hu, Y., Yu, H. & Wang, Y., Sep 23 2019, In : Chinese Medicine (United Kingdom). 14, 1, 35.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A role for urokinase in mediating phorbol ester induced macrophagelike maturation and adhesion of u937 and other myeloid cells

Nusrat, A. R., Mazar, A., Henkin, J. & Chapman, H. A., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Assessment of diphenylcyclopropenone for photochemically induced mutagenicity in the Ames assay

Wilkerson, M. G., Connor, T. H., Henkin, J., Wilkin, J. K. & Matney, T. S., Jan 1 1987, In : Journal of the American Academy of Dermatology. 17, 4, p. 606-611 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
Open Access
2 Scopus citations

A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo

Garside, S. A., Henkin, J., Morris, K. D., Norvell, S. M., Thomas, F. H. & Fraser, H. M., Dec 2010, In : Endocrinology. 151, 12, p. 5905-5915 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Automated Analysis of Protein Folding

Smith, R. A., Henkin, J. & Holzman, T. F., Jan 1 1995, In : Techniques in Protein Chemistry. 6, C, p. 459-466 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells

Wang, Y. F., Xu, Y. L., Tang, Z. H., Li, T., Zhang, L. L., Chen, X., Lu, J. H., Leung, C. H., Ma, D. L., Qiang, W. A., Wang, Y. T. & Lu, J. J., 2017, In : American Journal of Chinese Medicine. 45, 1, p. 123-136 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars

Dam, D. H. M., Culver, K. S. B., Kandela, I., Lee, R. C., Chandra, K., Lee, H., Mantis, C., Ugolkov, A., Mazar, A. P. & Odom, T. W., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 3, p. 671-679 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Lu, D., Yan, Y., Avila, R., Kandela, I., Stepien, I., Seo, M. H., Bai, W., Yang, Q., Li, C., Haney, C. R., Waters, E. A., MacEwan, M. R., Huang, Y., Ray, W. Z. & Rogers, J. A., Aug 1 2020, In : Advanced Healthcare Materials. 9, 16, 2000942.

Research output: Contribution to journalArticle

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Shin, J., Liu, Z., Bai, W., Liu, Y., Yan, Y., Xue, Y., Kandela, I., Pezhouh, M., MacEwan, M. R., Huang, Y., Ray, W. Z., Zhou, W. & Rogers, J. A., 2019, In : Science Advances. 5, 7, eaaw1899.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Bai, W., Shin, J., Fu, R., Kandela, I., Lu, D., Ni, X., Park, Y., Liu, Z., Hang, T., Wu, D., Liu, Y., Haney, C. R., Stepien, I., Yang, Q., Zhao, J., Nandoliya, K. R., Zhang, H., Sheng, X., Yin, L., MacRenaris, K. & 6 others, Brikha, A., Aird, F., Pezhouh, M., Hornick, J., Zhou, W. & Rogers, J. A., Aug 1 2019, In : Nature Biomedical Engineering. 3, 8, p. 644-654 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Shin, J., Yan, Y., Bai, W., Xue, Y., Gamble, P., Tian, L., Kandela, I., Haney, C. R., Spees, W., Lee, Y., Choi, M., Ko, J., Ryu, H., Chang, J. K., Pezhouh, M., Kang, S. K., Won, S. M., Yu, K. J., Zhao, J., Lee, Y. K. & 5 others, MacEwan, M. R., Song, S. K., Huang, Y., Ray, W. Z. & Rogers, J. A., Jan 1 2019, In : Nature Biomedical Engineering. 3, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Bolus dose response characteristics of single chain urokinase plasminogen activator and tissue plasminogen activator in a dog model of arterial thrombosis

Badylak, S. F., Voytik, S., Klabunde, R. E., Henkin, J. & Leski, M., Nov 15 1988, In : Thrombosis research. 52, 4, p. 295-312 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo

Serna, V. A., Wu, X., Qiang, W., Thomas, J., Blumenfeld, M. L. & Kurita, T., Jul 2018, In : Endocrine-related cancer. 25, 7, p. 747-759 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chapter 10. Thrombolytic Agents

Henkin, J. & Haire, W. D., Jan 1994, In : Annual Reports in Medicinal Chemistry. 29, C, p. 93-102 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of a metalloprotease which cleaves with high site-specificity the Glu(143)-Leu(144) bond of urokinase

Marcotte, P. A., Dudlak, D., Leski, M. L., Ryan, J. & Henkin, J., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA

Barnathan, E. S., Kuo, A., Karikó, K., Rosenfeld, L., Murray, S. C., Behrendt, N., Rønne, E., Weiner, D., Henkin, J. & Cines, D. B., 1990, In : Blood. 76, 9, p. 1795-1806 12 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Characterization of the activation of pro-urokinase by thermolysin

Marcotte, P. A. & Henkin, J., Jan 15 1993, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1161, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization of the Aldehyde Binding Site of Bacterial Luciferase by Photoaffinity Labeling

Tu, S. C. & Henkin, J., Jan 1 1983, In : Biochemistry. 22, 2, p. 519-523 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of urokinase receptor expression by human placental trophoblasts

Zini, J. M., Murray, S. C., Graham, C. H., Lala, P. K., Karikó, K., Barnathan, E. S., Mazar, A., Henkin, J., Cines, D. B. & McCrae, K. R., 1992, In : Blood. 79, 11, p. 2917-2929 13 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations

Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells

Chen, X., Wu, Q. S., Meng, F. C., Tang, Z. H., Chen, X., Lin, L. G., Chen, P., Qiang, W. A., Wang, Y. T., Zhang, Q. W. & Lu, J. J., Dec 1 2016, In : Phytomedicine. 23, 13, p. 1555-1565 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models

Ugolkov, A., Qiang, W., Bondarenko, G., Procissi, D., Gaisina, I., James, C. D., Chandler, J., Kozikowski, A., Gunosewoyo, H., O'Halloran, T., Raizer, J. & Mazar, A. P., Aug 2017, In : Translational Oncology. 10, 4, p. 669-678 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro

Zhong, Z. F., Tan, W., Tian, K., Yu, H., Qiang, W. A. & Wang, Y. T., Apr 2017, In : Oncology reports. 37, 4, p. 2016-2024 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparative localization of receptors for plasmin and for urokinase on MCF7 cells

Zhang, S., Laurent, M., Lopez-Alemany, R., Mazar, A., Henkin, J., Ronne, E. & Burtin, P., Aug 1993, In : Experimental Cell Research. 207, 2, p. 290-299 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Comparison of dose regimens for the administration of recombinant pro-urokinase in a canine thrombosis model

Burke, S. E., Lubbers, N. L., Nelson, R. A. & Henkin, J., May 1 1997, In : Thrombosis and Haemostasis. 77, 5, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comparison of model and nuclear magnetic resonance structures for the human inflammatory protein C5a

Zuiderweg, E. R. P., Henkin, J., Mollison, K. W., Carter, G. W. & Greer, J., 1988, In : Proteins: Structure, Function, and Bioinformatics. 3, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Competitive inhibitors of human urokinase

Yang, H. & Henkin, J., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 31-34 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors

Viloria-Petit, A., Miquerol, L., Yu, J. L., Gertsenstein, M., Sheehan, C., May, L., Henkin, J., Lobe, C., Nagy, A., Kerbel, R. S. & Rak, J., Aug 15 2003, In : EMBO Journal. 22, 16, p. 4091-4102 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma

Rusk, A., Cozzi, E., Stebbins, M., Vail, D., Graham, J., Valli, V., Henkin, J., Sharpee, R. & Khanna, C., Dec 15 2006, In : Clinical Cancer Research. 12, 24, p. 7456-7464 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Correlative abeling studies in light and electron microscopy

Kandela, I. K., Bleher, R. & Albrecht, R. M., Sep 24 2004, In : Microscopy and Microanalysis. 10, SUPPL. 2, p. 1212-1213 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

Ferber, S., Tiram, G., Sousa-Herves, A., Eldar-Boock, A., Krivitsky, A., Scomparin, A., Yeini, E., Ofek, P., Ben-Shushan, D., Vossen, L. I., Licha, K., Grossman, R., Ram, Z., Henkin, J., Ruppin, E., Auslander, N., Haag, R., Calderón, M. & Satchi-Fainaro, R., Oct 4 2017, In : eLife. 6, e25281.

Research output: Contribution to journalArticle

10 Scopus citations

Cytoprotective induction of nitric oxide synthase in a cellular model of 5-aminolevulinic acid-based photodynamic therapy

Bhowmick, R. & Girotti, A. W., May 1 2010, In : Free Radical Biology and Medicine. 48, 10, p. 1296-1301 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress

Bhowmick, R. & Girotti, A. W., Apr 1 2013, In : Free Radical Biology and Medicine. 57, p. 39-48 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line

Hollas, W., Soravia, E., Mazar, A., Henkin, J., Blasi, F. & Boyd, D., 1992, In : Biochemical Journal. 285, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

DES quinone: a reactive intermediate in diethylstilbestrol (DES) metabolism

Liehr, J. G., Ballatore, A. M., DaGue, B. B. & Henkin, J., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

Kawai, M., BaMaung, N. Y., Fidanze, S. D., Erickson, S. A., Tedrow, J. S., Sanders, W. J., Vasudevan, A., Park, C., Hutchins, C., Comess, K. M., Kalvin, D., Wang, J., Zhang, Q., Lou, P., Tucker-Garcia, L., Bouska, J., Bell, R. L., Lesniewski, R., Henkin, J. & Sheppard, G. S., Jul 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 13, p. 3574-3577 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Diethylstilbestrol (DES) quinone: A reactive intermediate in DES metabolism

Liehr, J. G., DaGue, B. B., Ballatore, A. M. & Henkin, J., Dec 15 1983, In : Biochemical Pharmacology. 32, 24, p. 3711-3718 8 p.

Research output: Contribution to journalArticle

72 Scopus citations