CLP - Developmental Therapeutics Core (DTC)

Research Output

2015

Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data

Reproducibility Project: Cancer Biology, May 5 2015, In : eLife. 4, MAY, p. 1-7 7 p., e06847.

Research output: Contribution to journalArticle

2 Scopus citations

Registered report: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

Reproducibility Project: Cancer Biology, May 22 2015, In : eLife. 4, MAY, p. 1-14 14 p., e06959.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin

Dalva-Aydemir, S., Bajpai, R., Martinez, M., Adekola, K. U. A., Kandela, I., Wei, C., Singhal, S., Koblinski, J. E., Raje, N. S., Rosen, S. T. & Shanmugam, M., Mar 1 2015, In : Clinical Cancer Research. 21, 5, p. 1161-1171 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
2014

Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy

Weichert, J. P., Clark, P. A., Kandela, I. K., Vaccaro, A. M., Clarke, W., Longino, M. A., Pinchuk, A. N., Farhoud, M., Swanson, K. I., Floberg, J. M., Grudzinski, J., Titz, B., Traynor, A. M., Chen, H. E., Hall, L. T., Pazoles, C. J., Pickhardt, P. J. & Kuo, J. S., Jun 11 2014, In : Science translational medicine. 6, 240, 240ra75.

Research output: Contribution to journalArticle

51 Scopus citations

Pro-survival and pro-growth effects of stress-induced nitric oxide in a prostate cancer photodynamic therapy model

Bhowmick, R. & Girotti, A. W., Feb 1 2014, In : Cancer Letters. 343, 1, p. 115-122 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and hodgkin lymphoma cells and human xenograft models

Ravi, D., Bhalla, S., Gartenhaus, R. B., Crombie, J., Kandela, I., Sharma, J., Mazar, A. & Evens, A. M., Dec 1 2014, In : Clinical Cancer Research. 20, 23, p. 6023-6033 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress

Bhowmick, R. & Girotti, A. W., Apr 1 2013, In : Free Radical Biology and Medicine. 57, p. 39-48 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

Miodragovic̈, D. U., Quentzel, J. A., Kurutz, J. W., Stern, C. L., Ahn, R. W., Kandela, I., Mazar, A. & O'Halloran, T. V., Oct 4 2013, In : Angewandte Chemie - International Edition. 52, 41, p. 10749-10752 4 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Prospective Study of Thrombospondin-1 Mimetic Peptides, ABT-510 and ABT-898, in Dogs with Soft Tissue Sarcoma

Sahora, A. I., Rusk, A. W., Henkin, J., McKeegan, E. M., Shi, Y. & Khanna, C., Sep 1 2012, In : Journal of Veterinary Internal Medicine. 26, 5, p. 1169-1176 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

ABT-898 induces tumor regression and prolongs survival in a mouse model of epithelial ovarian cancer

Campbell, N., Greenaway, J., Henkin, J. & Petrik, J., Oct 1 2011, In : Molecular cancer therapeutics. 10, 10, p. 1876-1885 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rapid upregulation of cytoprotective nitric oxide in breast tumor cells subjected to a photodynamic therapy-like oxidative challenge

Bhowmick, R. & Girotti, A. W., Mar 2011, In : Photochemistry and Photobiology. 87, 2, p. 378-386 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Therapies using anti-angiogenic peptide mimetics of thrombospondin-1

Henkin, J. & Volpert, O. V., Dec 1 2011, In : Expert Opinion on Therapeutic Targets. 15, 12, p. 1369-1386 18 p.

Research output: Contribution to journalReview article

40 Scopus citations
2010

A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo

Garside, S. A., Henkin, J., Morris, K. D., Norvell, S. M., Thomas, F. H. & Fraser, H. M., Dec 2010, In : Endocrinology. 151, 12, p. 5905-5915 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cytoprotective induction of nitric oxide synthase in a cellular model of 5-aminolevulinic acid-based photodynamic therapy

Bhowmick, R. & Girotti, A. W., May 1 2010, In : Free Radical Biology and Medicine. 48, 10, p. 1296-1301 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer

Campbell, N. E., Greenaway, J., Henkin, J., Moorehead, R. A. & Petrik, J., Mar 2010, In : Neoplasia. 12, 3, p. 275-283 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer

Greenaway, J., Henkin, J., Lawler, J., Moorehead, R. & Petrik, J., Jan 1 2009, In : Molecular cancer therapeutics. 8, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin

Bhowmick, R., Li, M., Sun, J., Baker, S. A., Insinna, C. & Besharse, J. C., 2009, In : Traffic. 10, 6, p. 648-663 16 p.

Research output: Contribution to journalArticle

43 Scopus citations

Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: Sensitization by radiation and requirement for GRP78 and LRP1

McFarland, B. C., Stewart, J., Hamza, A., Nordal, R., Davidson, D. J., Henkin, J. & Gladson, C. L., Jul 1 2009, In : Cancer Research. 69, 13, p. 5537-5545 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: Inhibitory effects of nitric oxide

Bhowmick, R. & Girotti, A. W., Sep 15 2009, In : Free Radical Biology and Medicine. 47, 6, p. 731-740 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2008

Immuno-EM using colloidal metal nanoparticles and electron spectroscopic imaging for co-localization at high spatial resolution

Bleher, R., Kandela, I., Meyer, D. A. & Albrecht, R. M., Jun 1 2008, In : Journal of Microscopy. 230, 3, p. 388-395 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immunolabeling for correlative light and electron microscopy on ultrathin cryosections

Kandela, I. K., Bleher, R. & Albrecht, R. M., Apr 1 2008, In : Microscopy and Microanalysis. 14, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Purification and characterization of a novel protease from the latex of Pedilanthus tithymaloids

Bhowmick, R., Prasanna Kumari, N. K., Jagannadham, M. V. & Kayastha, A. M., Sep 2008, In : Protein and Peptide Letters. 15, 9, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2007

ABT-510, a modified type 1 repeat peptide of thrombospondin, inhibits malignant glioma growth in vivo by inhibiting angiogenesis

Anderson, J. C., Grammer, J. R., Wang, W., Nabors, L. B., Henkin, J., Stewart, J. E. & Gladson, C. L., Mar 2007, In : Cancer Biology and Therapy. 6, 3, p. 454-462 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Fluorescence quenching by colloidal heavy metals nanoparticles: Implications for correlative fluorescence and electron microscopy studies

Kandela, I. K. & Albrecht, R. M., Jul 1 2007, In : Scanning. 29, 4, p. 152-161 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Multiple correlative immunolabeling for light and electron microscopy using fluorophores and colloidal metal particles

Kandela, I. K., Bleher, R. & Albrecht, R. M., Oct 1 2007, In : Journal of Histochemistry and Cytochemistry. 55, 10, p. 983-990 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma

Yang, Q., Tian, Y., Liu, S., Zeine, R., Chlenski, A., Salwen, H. R., Henkin, J. & Cohn, S. L., Feb 15 2007, In : Cancer Research. 67, 4, p. 1716-1724 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2006

Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma

Rusk, A., Cozzi, E., Stebbins, M., Vail, D., Graham, J., Valli, V., Henkin, J., Sharpee, R. & Khanna, C., Dec 15 2006, In : Clinical Cancer Research. 12, 24, p. 7456-7464 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

Kawai, M., BaMaung, N. Y., Fidanze, S. D., Erickson, S. A., Tedrow, J. S., Sanders, W. J., Vasudevan, A., Park, C., Hutchins, C., Comess, K. M., Kalvin, D., Wang, J., Zhang, Q., Lou, P., Tucker-Garcia, L., Bouska, J., Bell, R. L., Lesniewski, R., Henkin, J. & Sheppard, G. S., Jul 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 13, p. 3574-3577 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: A structural basis for the reduction of albumin binding

Sheppard, G. S., Wang, J., Kawai, M., Fidanze, S. D., BaMaung, N. Y., Erickson, S. A., Barnes, D. M., Tedrow, J. S., Kolaczkowski, L., Vasudevan, A., Park, D. C., Wang, G. T., Sanders, W. J., Mantei, R. A., Palazzo, F., Tucker-Garcia, L., Lou, P., Zhang, Q., Park, C. H., Kim, K. H. & 8 others, Petros, A., Olejniczak, E., Nettesheim, D., Hajduk, P., Henkin, J., Lesniewski, R., Davidsen, S. K. & Bell, R. L., Jun 29 2006, In : Journal of Medicinal Chemistry. 49, 13, p. 3832-3849 18 p.

Research output: Contribution to journalArticle

47 Scopus citations

Multiple intermediate conformations of jack bean urease at low pH: Anion-induced refolding

Bhowmick, R. & Jagannadham, M. V., Sep 1 2006, In : Protein Journal. 25, 6, p. 399-410 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers

Rusk, A., McKeegan, E., Haviv, F., Majest, S., Henkin, J. & Khanna, C., Dec 15 2006, In : Clinical Cancer Research. 12, 24, p. 7444-7455 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism

Aslanukov, A., Bhowmick, R., Guruju, M., Oswald, J., Raz, D., Bush, R. A., Sieving, P. A., Lu, X., Bock, C. B. & Ferreira, P. A., Oct 2006, In : PLoS genetics. 2, 10, p. 1653-1665 13 p.

Research output: Contribution to journalArticle

65 Scopus citations

The development of alternative markers for transmission electron microscopy and correlative transmission electon and light microscopies

Meyer, D. A., Bleher, R., Kandela, I. K., Oliver, J. A. & Albrecht, R. M., Aug 1 2006, In : Microscopy and Microanalysis. 12, SUPPL. 2, p. 32-33 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2005

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis

Shaked, Y., Bertolini, F., Man, S., Rogers, M. S., Cervi, D., Foutz, T., Rawn, K., Voskas, D., Dumont, D. J., Ben-David, Y., Lawler, J., Henkin, J., Huber, J., Hicklin, D. J., D'Amato, R. J. & Kerbel, R. S., Jan 1 2005, In : Cancer Cell. 7, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

328 Scopus citations

Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78

Davidson, D. J., Haskell, C., Majest, S., Kherzai, A., Egan, D. A., Walter, K. A., Schneider, A., Gubbins, E. F., Solomon, L., Chen, Z., Lesniewski, R. & Henkin, J., Jun 1 2005, In : Cancer Research. 65, 11, p. 4663-4672 10 p.

Research output: Contribution to journalArticle

185 Scopus citations

Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: A complementation antiangiogenic strategy

Yap, R., Veliceasa, D., Emmenegger, U., Kerbel, R. S., McKay, L. M., Henkin, J. & Volpert, O. V., Sep 15 2005, In : Clinical Cancer Research. 11, 18, p. 6678-6685 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Micro arrayed compound screening (μARCS) for inhibitors of methionine aminopeptidase type 2

Fan, Y., Wang, J., Lou, P., Henkin, J., Kofron, J. L., Burns, D. J., Warrior, U. & Anderson, S. N., Sep 2005, In : Letters in Drug Design and Discovery. 2, 6, p. 462-469 8 p.

Research output: Contribution to journalArticle

Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: Design, synthesis, and optimization of pharmacokinetics and biological activities

Haviv, F., Bradley, M. F., Kalvin, D. M., Schneider, A. J., Davidson, D. J., Majest, S. M., McKay, L. M., Haskell, C. J., Bell, R. L., Nguyen, B., Marsh, K. C., Surber, B. W., Uchic, J. T., Ferrero, J., Wang, Y. C., Leal, J., Record, R. D., Hodde, J., Badylak, S. F., Lesniewski, R. R. & 1 others, Henkin, J., Apr 21 2005, In : Journal of Medicinal Chemistry. 48, 8, p. 2838-2846 9 p.

Research output: Contribution to journalArticle

106 Scopus citations
2004

3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2

Sheppard, G. S., Wang, J., Kawai, M., BaMaung, N. Y., Craig, R. A., Erickson, S. A., Lynch, L., Patel, J., Yang, F., Searle, X. B., Lou, P., Park, C., Kim, K. H., Henkin, J. & Lesniewski, R., Feb 23 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 4, p. 865-868 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Correlative abeling studies in light and electron microscopy

Kandela, I. K., Bleher, R. & Albrecht, R. M., Sep 24 2004, In : Microscopy and Microanalysis. 10, SUPPL. 2, p. 1212-1213 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5

Sheppard, G. S., Kawai, M., Craig, R. A., Davidson, D. J., Majest, S. M., Bell, R. L. & Henkin, J., Feb 23 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 4, p. 965-966 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Peroxisome proliferator-activated receptor γ ligands improve the antitumor efficacy of thrombospondin peptide ABT510

Huang, H., Campbell, S. C., Bedford, D. F., Nelius, T., Veliceasa, D., Shroff, E. H., Henkin, J., Schneider, A., Bouck, N. & Volpert, O. V., Oct 1 2004, In : Molecular Cancer Research. 2, 10, p. 541-550 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
2003

Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors

Viloria-Petit, A., Miquerol, L., Yu, J. L., Gertsenstein, M., Sheehan, C., May, L., Henkin, J., Lobe, C., Nagy, A., Kerbel, R. S. & Rak, J., Aug 15 2003, In : EMBO Journal. 22, 16, p. 4091-4102 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Effect of the lipophilic/hydrophilic character of cationic triarylmethane dyes on their selective phototoxicity toward tumor cells

Kandela, I., Lee, W. & Indig, G. L., Jun 1 2003, In : Biotechnic and Histochemistry. 78, 3-4, p. 157-169 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Fluorescence quenching by colloidal heavy metals: Implications for correlative fluorescence and electron microscopy studies

Kandela, I. K., Meyer, D. A., Oshel, P. E., Rosa-Molinar, E. & Albrecht, R. M., Jan 1 2003, In : Microscopy and Microanalysis. 9, SUPPL. 2, p. 1194-1195 2 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly

Wang, J., Lou, P., Lesniewski, R. & Henkin, J., Jan 1 2003, In : Anti-Cancer Drugs. 14, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

177 Scopus citations

Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese

Wang, J., Sheppard, G. S., Lou, P., Kawai, M., Park, C., Egan, D. A., Schneider, A., Bouska, J., Lesniewski, R. & Henkin, J., May 6 2003, In : Biochemistry. 42, 17, p. 5035-5042 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Recombinant, glycosylated prourokinase: preclinical and clinical studies

Henkin, J., 2003, New Therapeutic Agents in Thrombosis and Thrombolysis. New York: Marcel Dekker, p. 557-582

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Tumor Suppression by a Rationally Designed Reversible Inhibitor of Methionine Aminopeptidase-2

Wang, J., Sheppard, G. S., Lou, P., Kawai, M., BaMaung, N., Erickson, S. A., Tucker-Garcia, L., Park, C., Bouska, J., Wang, Y. C., Frost, D., Tapang, P., Albert, D. H., Morgan, S. J., Morowitz, M., Shusterman, S., Maris, J. M., Lesniewski, R. & Henkin, J., Nov 15 2003, In : Cancer Research. 63, 22, p. 7861-7869 9 p.

Research output: Contribution to journalArticle

61 Scopus citations