CLP - Developmental Therapeutics Core (DTC)

Research Output

2002

Effect of molecular structure on the selective photoxicity of triarylmethane dyes towards tumor cells

Kandela, I. K., Bartlett, J. A. & Indig, G. L., May 1 2002, In : Photochemical and Photobiological Sciences. 1, 5, p. 309-314 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics

Reiher, F. K., Volpert, O. V., Jimenez, B., Crawford, S. E., Dinney, C. P., Henkin, J., Haviv, F., Bouck, N. P. & Campbell, S. C., Apr 10 2002, In : International Journal of Cancer. 98, 5, p. 682-689 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration

Li, Y., Knisely, J. M., Lu, W., McCormick, L. M., Wang, J., Henkin, J., Schwartz, A. L. & Bu, G., Nov 1 2002, In : Journal of Biological Chemistry. 277, 44, p. 42366-42371 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2000

Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite

Nienaber, V., Wang, J., Davidson, D. & Henkin, J., Mar 10 2000, In : Journal of Biological Chemistry. 275, 10, p. 7239-7248 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
91 Scopus citations

Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite

Nienaber, V. L., Davidson, D., Edalji, R., Giranda, V. L., Klinghofer, V., Henkin, J., Magdalinos, P., Mantei, R., Merrick, S., Severin, J. M., Smith, R. A., Stewart, K., Walter, K., Wang, J., Wendt, M., Weitzberg, M., Zhao, X. & Rockway, T., May 1 2000, In : Structure. 8, 5, p. 553-563 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
1999

The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis

Mazar, A. P., Henkin, J. & Goldfarb, R. H., Jan 1 1999, In : Angiogenesis. 3, 1, p. 15-32 18 p.

Research output: Contribution to journalReview article

150 Scopus citations

Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat

Dawson, D. W., Volpert, O. V., Frieda, S., Schneider, A. J., Silverstein, R. L., Henkin, J. & Bouck, N. P., 1999, In : Molecular pharmacology. 55, 2, p. 332-338 7 p.

Research output: Contribution to journalArticle

128 Scopus citations
1998

Workgroup 3: Transgenic and reconstitution models of prostate cancer

Green, J. E., Greenberg, N. M., Ashendel, C. L., Barrett, J. C., Boone, C., Getzenberg, R. H., Henkin, J., Matusik, R., Janus, T. J. & Scher, H. I., Jun 15 1998, In : Prostate. 36, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

46 Scopus citations
1997

Comparison of dose regimens for the administration of recombinant pro-urokinase in a canine thrombosis model

Burke, S. E., Lubbers, N. L., Nelson, R. A. & Henkin, J., May 1 1997, In : Thrombosis and Haemostasis. 77, 5, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
92 Scopus citations

Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase

Rabbani, S. A., Gladu, J., Mazar, A. P., Henkin, J. & Goltzman, D., Aug 1 1997, In : Journal of Cellular Physiology. 172, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Plasminogen activation by pro-urokinase in complex with its receptor: Dependence on a tripeptide (Spectrozyme plasmin)

Wang, J., Mazar, A., Quan, N., Schneider, A. & Henkin, J., Jan 1 1997, In : European Journal of Biochemistry. 247, 1, p. 256-261 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B- 428

Xing, R. H., Mazar, A., Henkin, J. & Rabbani, S. A., Aug 15 1997, In : Cancer Research. 57, 16, p. 3585-3593 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Role of urokinase (upa) and its receptor (upar) in breast cancer growth, invasion and metastasis: potential therapeutic strategies

Xing, R. H., Mazar, A. & Henkin, J., Dec 1 1997, In : Fibrinolysis and Proteolysis. 11, SUPPL. 3, 1 p.

Research output: Contribution to journalArticle

Soluble human urokinase receptor is composed of two active units

Higazi, A. A. R., Mazar, A., Wang, J., Quan, N., Griffin, R., Reilly, R., Henkin, J. & Cines, D. B., Feb 21 1997, In : Journal of Biological Chemistry. 272, 8, p. 5348-5353 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
1996

Differential effects of lys- and mini-plasminogen on clot lysis induced by recombinant urokinase and recombinant pro-urokinase in a canine thrombosis model

Burke, S. E., Davidson, D. J., Lubbers, N. L., Reininger, I. M. & Henkin, J., Sep 15 1996, In : Thrombosis Research. 83, 6, p. 421-431 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins

Higazi, A. A. R., Upson, R. H., Cohen, R. L., Manuppello, J., Bognacki, J., Henkin, J., McCrae, K. R., Kounnas, M. Z., Strickland, D. K., Preissner, K. T., Lawler, J. & Cines, D. B., Jul 15 1996, In : Blood. 88, 2, p. 542-551 10 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Single chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1

Higazi, A. A. I. R., Mazar, A., Wang, J., Reilly, R., Henkin, J., Kniss, D. & Cines, D., Dec 1 1996, In : Fibrinolysis. 10, SUPPL. 3, 1 p.

Research output: Contribution to journalArticle

Single-chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1

Higazi, A. A. R., Mazar, A., Wang, J., Reilly, R., Henkin, J., Kniss, D. & Cines, D., May 1 1996, In : Blood. 87, 9, p. 3545-3549 5 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Thermal stability of low molecular weight urokinase during heat treatment. III. Effect of salts, sugars and Tween 80

Foster, T. M., Dormish, J. J., Narahari, U., Meyer, J. D., Vrkljan, M., Henkin, J., Porter, W. R., Staack, H., Carpenter, J. F. & Manninga, M. C., May 28 1996, In : International Journal of Pharmaceutics. 134, 1-2, p. 193-201 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
1995

Automated Analysis of Protein Folding

Smith, R. A., Henkin, J. & Holzman, T. F., Jan 1 1995, In : Techniques in Protein Chemistry. 6, C, p. 459-466 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enhancement of the enzymatic activity of single-chain urokinase plasminogen activator by soluble urokinase receptor

Higazi, A. A. R., Cohen, R. L., Henkin, J., Kniss, D., Schwartz, B. S. & Cines, D. B., 1995, In : Journal of Biological Chemistry. 270, 29, p. 17375-17380 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

gp330 on type II pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex

Stefansson, S., Kounnas, M. Z., Henkin, J., Mallampalli, R. K., Chappell, D. A., Strickland, D. K. & Argraves, W. S., Jan 1 1995, In : Journal of Cell Science. 108, 6, p. 2361-2368 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Prevention of prostate‐cancer metastasis in vivo by a novel synthetic inhibitor of urokinase‐type plasminogen activator (uPA)

Rabbani, S., Harakidas, P., Davidson, D. J., Henkin, J. & Mazar, A. P., Dec 11 1995, In : International Journal of Cancer. 63, 6, p. 840-845 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Prourokinase: a new clot selective thrombolytic agent

Henkin, J., 1995, Thrombolytic Therapy for Peripheral Vascular Disease. Philadelphia: J.B. Lippincott Co., p. 133-141

Research output: Chapter in Book/Report/Conference proceedingChapter

Studies of possible mechanisms for the effect of urokinase therapy in small cell carcinoma of the lung

Meehan, K. R., Zacharski, L. R., Maurer, L. H., Howell, A. L., Memoli, V. A., Rousseau, S. M., Hunt, J. A. & Henkin, J., 1995, In : Blood Coagulation and Fibrinolysis. 6, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
1994

Chapter 10. Thrombolytic Agents

Henkin, J. & Haire, W. D., Jan 1994, In : Annual Reports in Medicinal Chemistry. 29, C, p. 93-102 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model

Hart, D. A., Whidden, P., Green, F., Henkin, J. & Woods, D. E., Jan 1 1994, In : Clinical and Investigative Medicine. 17, 2, p. 69-76 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator

Hansen, A. P., Petros, A. M., Meadows, R. P., Nettesheim, D. G., Mazar, A. P., Olejniczak, E. T., Xu, R. X., Pederson, T. M., Henkin, J. & Fesik, S. W., Apr 1 1994, In : Biochemistry. 33, 16, p. 4847-4864 18 p.

Research output: Contribution to journalArticle

105 Scopus citations

Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric Additives

Vrkljan, M., Foster, T. M., Powers, M. E., Henkin, J., Porter, W. R., Staack, H., Carpenter, J. F. & Manning, M. C., Jul 1994, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11, 7, p. 1004-1008 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Urokinase inhibits HL-60 cell proliferation in vitro

Howell, A. L., Hunt, J. A., James, T. W., Mazar, A., Henkin, J. & Zacharski, L. R., Jan 1 1994, In : Blood Coagulation and Fibrinolysis. 5, 4, p. 445-453 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
1993

Characterization of the activation of pro-urokinase by thermolysin

Marcotte, P. A. & Henkin, J., Jan 15 1993, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1161, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Comparative localization of receptors for plasmin and for urokinase on MCF7 cells

Zhang, S., Laurent, M., Lopez-Alemany, R., Mazar, A., Henkin, J., Ronne, E. & Burtin, P., Aug 1993, In : Experimental Cell Research. 207, 2, p. 290-299 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Divergent effect of n,n-dimethylformamide on the expression of urokinase and its receptor

Hollas, W., Kariko, K., Barnathan, E., Mazar, A., Henkin, J. & Boyd, D., Jan 1 1993, In : Fibrinolysis and Proteolysis. 7, 3, p. 149-157 9 p.

Research output: Contribution to journalArticle

Exogenous rh-urokinase modifies inflammation and Pseudomonas aeruginosa infection in a rat chronic pulmonary infection model

Hart, D. A., Green, F., Whidden, P., Henkin, J. & Woods, D. E., Jan 1 1993, In : Canadian Journal of Microbiology. 39, 12, p. 1127-1134 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Low density lipoprotein receptor-related protein/α2-macroglobulin receptor mediates cellular uptake of pro-urokinase

Kounnas, M. Z., Henkin, J., Argraves, W. S. & Strickland, D. K., Jan 1 1993, In : Journal of Biological Chemistry. 268, 29, p. 21862-21867 6 p.

Research output: Contribution to journalArticle

141 Scopus citations

Nerve growth factor-γ activates soluble and receptor-bound single chain urokinase-type plasminogen activator

Wolf, B. B., Vasudevan, J., Henkin, J. & Gonias, S. L., Jan 1 1993, In : Journal of Biological Chemistry. 268, 22, p. 16327-16331 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Proteases and Metastasis

Henkin, J., Jan 1 1993, In : Annual Reports in Medicinal Chemistry. 28, C, p. 151-160 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Recombinant pro-urokinase requires heparin for optimal clot lysis and restoration of blood flow in a canine femoral artery thrombosis model

Burke, S. E., Lubbers, N. L., Nelson, R. A. & Henkin, J., Jan 1 1993, In : Thrombosis and Haemostasis. 69, 4, p. 375-380 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulation of urokinase‐type plasminogen activator expression in squamous‐cell carcinoma of the oral cavity

Clayman, G., Goepfert, H., Boyd, D. D., Wang, S. W., Nicolson, G. L., El‐Naggar, A., Mazar, A., Henkin, J. & Blasi, F., Apr 22 1993, In : International Journal of Cancer. 54, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
1992

A-chain isozymes of recombinant and natural urokinases: Preparation, characterization, and their biochemical and fibrinolytic properties

Marcotte, P. A., Henkin, J., Credo, R. B. & Badylak, S. F., Apr 1992, In : Fibrinolysis and Proteolysis. 6, 2, p. 69-78 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A chromogenic enzymatic assay capable of detecting prourokinase-like material in plasma

Kebabian, P. R. & Henkin, J., Feb 1 1992, In : Thrombosis Research. 65, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Advances in peripheral vascular thrombolysis: recombinant technology and methodologies to enhance lysis

Sasahara, A. A., Henkin, J., Barker, W. M., Lewkowski, J. P., Burke, S. E., Sobolski, J. C., St. Martin, C. C. & Schultz, G. A., 1992, Technologies in Vascular Surgery. Yao, J. S. T. & Pearce, W. H. (eds.). Philadelphia: W.B. Saunders, p. 449-474

Research output: Chapter in Book/Report/Conference proceedingChapter

Approach to the patient with venous thromboembolism: Treatment with thrombolytic agents

Sasahara, A. A., St. Martin, C. C., Henkin, J. & Barker, W. M., Jan 1 1992, In : Hematology/Oncology Clinics of North America. 6, 5, p. 1141-1159 19 p.

Research output: Contribution to journalReview article

7 Scopus citations

A role for urokinase in mediating phorbol ester induced macrophagelike maturation and adhesion of u937 and other myeloid cells

Nusrat, A. R., Mazar, A., Henkin, J. & Chapman, H. A., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of a metalloprotease which cleaves with high site-specificity the Glu(143)-Leu(144) bond of urokinase

Marcotte, P. A., Dudlak, D., Leski, M. L., Ryan, J. & Henkin, J., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 57-62 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of urokinase receptor expression by human placental trophoblasts

Zini, J. M., Murray, S. C., Graham, C. H., Lala, P. K., Karikó, K., Barnathan, E. S., Mazar, A., Henkin, J., Cines, D. B. & McCrae, K. R., 1992, In : Blood. 79, 11, p. 2917-2929 13 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations

Competitive inhibitors of human urokinase

Yang, H. & Henkin, J., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 31-34 4 p.

Research output: Contribution to journalArticle

10 Scopus citations