CLP - Developmental Therapeutics Core (DTC)

Research Output

1992

Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line

Hollas, W., Soravia, E., Mazar, A., Henkin, J., Blasi, F. & Boyd, D., 1992, In : Biochemical Journal. 285, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Domain analysis of urokinase plasminogen activator (u-PA): Preparation and characterization of intact A-chain molecules

Mazar, A. P., Buko, A., Petros, A. M., Barnathan, E. S. & Henkin, J., Jan 1 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Domain structure and interactions of recombinant urokinase-type plasminogen activator

Novokhatny, V., Medved, L., Mazar, A., Marcotte, P., Henkin, J. & Ingham, K., 1992, In : Journal of Biological Chemistry. 267, 6, p. 3878-3885 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Expression of urokinase and its receptor in invasive and non-invasive prostate cancer cell lines

Hollas, W., Hoosein, N., Chung, L. W. K., Mazar, A., Henkin, J., Kariko, K., Barnathan, E. S. & Boyd, D., Jan 1 1992, In : Thrombosis and Haemostasis. 68, 6, p. 662-666 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

New Developments in Thrombolytic Therapy

Badylak, S. F., Henkin, J., Burke, S. E. & Sasahara, A. A., Jan 1 1992, In : Advances in Pharmacology. 23, C, p. 227-262 36 p.

Research output: Contribution to journalArticle

2 Scopus citations

Preface

Henkin, J. & Sasahara, A. A., Jan 1992, In : Fibrinolysis and Proteolysis. 6, SUPPL. 1, 1 p.

Research output: Contribution to journalEditorial

Structural requirements for the growth factor activity of the amino- terminal domain of urokinase

Rabbani, S. A., Mazar, A. P., Bernier, S. M., Haq, M., Bolivar, I., Henkin, J. & Goltzman, D., Jan 1 1992, In : Journal of Biological Chemistry. 267, 20, p. 14151-14156 6 p.

Research output: Contribution to journalArticle

224 Scopus citations

The influence of glycosylation on the catalytic and fibrinolytic properties of pro-Urokinase

Lenich, C., Pannell, R., Henkin, J. & Gurewich, V., 1992, In : Thrombosis and Haemostasis. 68, 5, p. 539-544 6 p.

Research output: Contribution to journalArticle

29 Scopus citations
1991

Enhancement of the thrombolytic efficacy of prourokinase by lys-plasminogen in a dog model of arterial thrombosis

Badylak, S. F., Voytik, S. L., Henkin, J., Burke, S. E., Sasahara, A. A. & Simmons, A., May 1 1991, In : Thrombosis research. 62, 3, p. 115-126 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

High sialic acid content slows prourokinase turnover in rabbits

Henkin, J., Dudlak, D., Beebe, D. P. & Sennello, L., Jul 15 1991, In : Thrombosis Research. 63, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines

Hoosein, N. M., Boyd, D. D., Hollas, W. J., Mazar, A., Henkin, J. & Chung, L. W. K., 1991, In : Cancer Communications. 3, 8, p. 255-264 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

The beneficial effect of lys-plasminogen upon the thrombolytic efficacy of urokinase in a dog model of peripheral arterial thrombosis

Badylak, S. F., Voytik, S. L., Henkin, J., Burke, S., Sasahara, A. A. & Simmons, A., 1991, In : Pathophysiology of Haemostasis and Thrombosis. 21, 5, p. 278-285 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

The plasminogen-plasmin system

Henkin, J., Marcotte, P. & Yang, H., Jan 1 1991, In : Progress in Cardiovascular Diseases. 34, 2, p. 135-164 30 p.

Research output: Contribution to journalArticle

65 Scopus citations
1990

Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis

Gallo, R. L., Henkin, J., Knowles, M. R., Church, N. L., Waltner, W. E., Yankaskas, J. R., Gilligan, P., King, M., Edwards, L. J., Helms, R. W. & Boucher, R. C., Oct 4 1990, In : New England Journal of Medicine. 323, 14, p. 996-998 3 p.

Research output: Contribution to journalLetter

6 Scopus citations

Aerosolized amiloride for the treatment of lung disease in cystic fibrosis (II)

Henkin, J., Jan 1 1990, In : New England Journal of Medicine. 323, 14, 1 p.

Research output: Contribution to journalLetter

An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells

Rabbani, S. A., Desjardins, J., Bell, A. W., Banville, D., Mazar, A., Henkin, J. & Goltzman, D., Dec 31 1990, In : Biochemical and Biophysical Research Communications. 173, 3, p. 1058-1064 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA

Barnathan, E. S., Kuo, A., Karikó, K., Rosenfeld, L., Murray, S. C., Behrendt, N., Rønne, E., Weiner, D., Henkin, J. & Cines, D. B., 1990, In : Blood. 76, 9, p. 1795-1806 12 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Enhanced lytic efficacy of multiple bolus injections of tissue plasminogen activator in dogs

Klabunde, R. E., Burke, S. E. & Henkin, J., Jun 1 1990, In : Thrombosis Research. 58, 5, p. 511-517 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells

Barnathan, E. S., Kuo, A., Rosenfeld, L., Kariko, K., Leski, M., Robbiati, F., Nolli, M. L., Henkin, J. & Cines, D. B., 1990, In : Journal of Biological Chemistry. 265, 5, p. 2865-2872 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Selective binding of plasmin in the presence of excess plasminogen by certain anionic polystyrene resins

Yang, H. & Henkin, J., Jul 1 1990, In : Thrombosis Research. 59, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The protective effect of heparin in a dog model of rethrombosis following pharmacologic thrombolysis

Voytik, S., Badylak, S. F., Burke, S., Klabunde, R. E., Henkin, J. & Simmons, A., 1990, In : Thrombosis and Haemostasis. 64, 3, p. 438-444 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
1988

Bolus dose response characteristics of single chain urokinase plasminogen activator and tissue plasminogen activator in a dog model of arterial thrombosis

Badylak, S. F., Voytik, S., Klabunde, R. E., Henkin, J. & Leski, M., Nov 15 1988, In : Thrombosis research. 52, 4, p. 295-312 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Comparison of model and nuclear magnetic resonance structures for the human inflammatory protein C5a

Zuiderweg, E. R. P., Henkin, J., Mollison, K. W., Carter, G. W. & Greer, J., 1988, In : Proteins: Structure, Function, and Bioinformatics. 3, 3, p. 139-145 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Optimizing the bolus/infusion ratio for intravenous administration of urokinase in dogs

Klabunde, R. E., Hemenway, C. C., Mohrman, S. J., Henkin, J. & Badylak, S. F., Jun 15 1988, In : Thrombosis research. 50, 6, p. 857-864 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sequence-Specific Assignments in the1H NMR Spectrum of the Human Inflammatory Protein C5a

Zuiderweg, E. R. P., Mollison, K. W., Henkin, J. & Carter, G. W., May 1 1988, In : Biochemistry. 27, 10, p. 3568-3580 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

UROKINASE VERSUS TISSUE PLASMINOGEN ACTIVATOR IN PULMONARY EMBOLISM

Sasahara, A., Henkin, J., Janicki, R., Stern, M., Meyer, G., Sors, H., Gaffney, P. & Thomas, D., Sep 17 1988, In : The Lancet. 332, 8612, p. 691-692 2 p.

Research output: Contribution to journalLetter

17 Scopus citations
1987

Assessment of diphenylcyclopropenone for photochemically induced mutagenicity in the Ames assay

Wilkerson, M. G., Connor, T. H., Henkin, J., Wilkin, J. K. & Matney, T. S., Jan 1 1987, In : Journal of the American Academy of Dermatology. 17, 4, p. 606-611 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
1985

Affinity labeling of dihydrofolate reductase with an antifolate glyoxal

Johanson, R. A. & Henkin, J., Jan 1 1985, In : Journal of Biological Chemistry. 260, 3, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Squaric acid and esters: Analysis for contaminants and stability in solvents

Wilkerson, M. G., Henkin, J., Wilkin, J. K. & Smith, R. G., Jan 1 1985, In : Journal of the American Academy of Dermatology. 13, 2, p. 229-234 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
1984

Affinity labeling of dihydrofolate reductase with an antifolate glyoxal

Henkin, J. & Johanson, R. A., Jan 1 1984, In : Federation Proceedings. 43, 7

Research output: Contribution to journalArticle

Diphenylcyclopropenone: Examination for potential contaminants, mechanisms of sensitization, and photochemical stability

Wilkerson, M. G., Henkin, J. & Wilkin, J. K., Jan 1 1984, In : Journal of the American Academy of Dermatology. 11, 5, p. 802-807 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Isotope, Pulse-Chase, Stopped-Flow, and Rapid Quench Studies on the Kinetic Mechanism of Bovine Dihydropteridine Reductase

Poddar, S. & Henkin, J., Jan 1 1984, In : Biochemistry. 23, 14, p. 3143-3148 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
1983

Characterization of the Aldehyde Binding Site of Bacterial Luciferase by Photoaffinity Labeling

Tu, S. C. & Henkin, J., Jan 1 1983, In : Biochemistry. 22, 2, p. 519-523 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Diethylstilbestrol (DES) quinone: A reactive intermediate in DES metabolism

Liehr, J. G., DaGue, B. B., Ballatore, A. M. & Henkin, J., Dec 15 1983, In : Biochemical Pharmacology. 32, 24, p. 3711-3718 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Novel Fluorinated Antifolates. Enzyme Inhibition and Cytotoxicity Studies on 2′- and 3′-Fluoroaminopterin

Henkin, J. & Washtien, W. L., Jan 1 1983, In : Journal of Medicinal Chemistry. 26, 8, p. 1193-1196 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
1982

Anthranilate synthase of Neurospora crassa: Reaction and labeling with glutamine analogs

Paukert, J. L., Henkin, J., Keesey, J. & Demoss, J. A., Oct 15 1982, In : Archives of biochemistry and biophysics. 218, 2, p. 443-449 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

DES quinone: a reactive intermediate in diethylstilbestrol (DES) metabolism

Liehr, J. G., Ballatore, A. M., DaGue, B. B. & Henkin, J., Jan 1 1982, In : Federation Proceedings. 41, 5, 1 p.

Research output: Contribution to journalArticle

Equilibrium constants under physiological conditions for the condensation of acetaldehyde with tetrahydrofolic acid

Guynn, R. W., Labaume, L. B. & Henkin, J., Aug 1982, In : Archives of biochemistry and biophysics. 217, 1, p. 181-190 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Photochemical and biochemical characterization of 2'-azidoaminopterin: A novel photoreactive antifolate

Henkin, J., Liehr, J. G. & Holmes, P. F., Jan 1 1982, In : Federation proceedings. 41, 4

Research output: Contribution to journalArticle

Synthesis and characterization of 2′-azidoaminopterin as a potential photoaffinity label for folate-utilizing enzymes

Holmes, P. F., Liehr, J. G. & Henkin, J., Jan 1 1982, In : Bioorganic Chemistry. 11, 3, p. 281-299 19 p.

Research output: Contribution to journalArticle

8 Scopus citations
1977

Photolabeling reagent for thiol enzymes. Studies on rabbit muscle creatine kinase

Henkin, J., Jan 1 1977, In : Journal of Biological Chemistry. 252, 12, p. 4293-4297 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
1976

Evidence Against an Acyl-Enzyme Intermediate in the Reaction Catalyzed by Clostridial Phosphotransacetylase

Henkin, J., Aug 1 1976, In : Biochemistry. 15, 16, p. 3472-3479 8 p.

Research output: Contribution to journalArticle

24 Scopus citations