CLP - Developmental Therapeutics Core (DTC)

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2020

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Lu, D., Yan, Y., Avila, R., Kandela, I., Stepien, I., Seo, M. H., Bai, W., Yang, Q., Li, C., Haney, C. R., Waters, E. A., MacEwan, M. R., Huang, Y., Ray, W. Z. & Rogers, J. A., 2020, (Accepted/In press) In : Advanced Healthcare Materials.

Research output: Contribution to journalArticle

Inhibition of retinal neovascularization by a PEDF-derived nonapeptide in newborn mice subjected to oxygen-induced ischemic retinopathy

Sheibani, N., Zaitoun, I. S., Wang, S., Darjatmoko, S. R., Suscha, A., Song, Y. S., Sorenson, C. M., Shifrin, V., Albert, D. M., Melgar-Asensio, I., Kandela, I. & Henkin, J., Jun 2020, In : Experimental eye research. 195, 108030.

Research output: Contribution to journalArticle

Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics

Burton, A., Obaid, S. N., Vázquez-Guardado, A., Schmit, M. B., Stuart, T., Cai, L., Chen, Z., Kandela, I., Haney, C. R., Waters, E. A., Cai, H., Rogers, J. A., Lu, L. & Gutruf, P., Feb 11 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 2835-2845 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: Combined in vitro and in silico investigations

Zhong, Z., Zhang, Q., Tao, H., Sang, W., Cui, L., Qiang, W., Cheang, W. S., Hu, Y., Yu, H. & Wang, Y., Sep 23 2019, In : Chinese Medicine (United Kingdom). 14, 1, 35.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
2 Scopus citations

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Shin, J., Liu, Z., Bai, W., Liu, Y., Yan, Y., Xue, Y., Kandela, I., Pezhouh, M., MacEwan, M. R., Huang, Y., Ray, W. Z., Zhou, W. & Rogers, J. A., 2019, In : Science Advances. 5, 7, eaaw1899.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Bai, W., Shin, J., Fu, R., Kandela, I., Lu, D., Ni, X., Park, Y., Liu, Z., Hang, T., Wu, D., Liu, Y., Haney, C. R., Stepien, I., Yang, Q., Zhao, J., Nandoliya, K. R., Zhang, H., Sheng, X., Yin, L., Macrenaris, K. W. & 6 others, Brikha, A., Aird, F., Pezhouh, M., Hornick, J., Zhou, W. & Rogers, J. A., Aug 1 2019, In : Nature Biomedical Engineering. 3, 8, p. 644-654 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Shin, J., Yan, Y., Bai, W., Xue, Y., Gamble, P., Tian, L., Kandela, I., Haney, C. R., Spees, W., Lee, Y., Choi, M., Ko, J., Ryu, H., Chang, J. K., Pezhouh, M., Kang, S. K., Won, S. M., Yu, K. J., Zhao, J., Lee, Y. K. & 5 others, MacEwan, M. R., Song, S. K., Huang, Y., Ray, W. Z. & Rogers, J. A., Jan 1 2019, In : Nature Biomedical Engineering. 3, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Human organoids share structural and genetic features with primary pancreatic adenocarcinoma tumors

Romero-Calvo, I., Weber, C. R., Ray, M., Brown, M., Kirby, K., Nandi, R. K., Long, T. M., Sparrow, S. M., Ugolkov, A., Qiang, W., Zhang, Y., Brunetti, T., Kindler, H., Segal, J. P., Rzhetsky, A., Mazar, A. P., Buschmann, M. M., Weichselbaum, R., Roggin, K. & White, K. P., Jan 1 2019, In : Molecular Cancer Research. 17, 1, p. 70-83 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b

Lin, K., Qiang, W., Zhu, M., Ding, Y., Shi, Q., Chen, X., Zsiros, E., Wang, K., Yang, X., Kurita, T. & Xu, E. Y., Feb 26 2019, In : Cell reports. 26, 9, p. 2434-2450.e6

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization

Sheibani, N., Wang, S., Darjatmoko, S. R., Fisk, D. L., Shahi, P. K., Pattnaik, B. R., Sorenson, C. M., Bhowmick, R., Volpert, O., Albert, D. M., Melgar-Asensio, I. & Henkin, J., Nov 2019, In : Experimental eye research. 188, 107798.

Research output: Contribution to journalArticle

4 Scopus citations

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Han, H., Jain, A. D., Truica, M. I., Izquierdo-Ferrer, J., Anker, J. F., Lysy, B., Sagar, V., Luan, Y., Chalmers, Z. R., Unno, K., Mok, H., Vatapalli, R., Yoo, Y. A., Rodriguez, Y., Kandela, I., Parker, J. B., Chakravarti, D., Mishra, R. K., Schiltz, G. E. & Abdulkadir, S. A., Nov 11 2019, In : Cancer Cell. 36, 5, p. 483-497.e15

Research output: Contribution to journalArticle

7 Scopus citations

Three-dimensional piezoelectric polymer microsystems for vibrational energy harvesting, robotic interfaces and biomedical implants

Han, M., Wang, H., Yang, Y., Liang, C., Bai, W., Yan, Z., Li, H., Xue, Y., Wang, X., Akar, B., Zhao, H., Luan, H., Lim, J., Kandela, I., Ameer, G. A., Zhang, Y., Huang, Y. & Rogers, J. A., Jan 1 2019, In : Nature Electronics. 2, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

USP7 cooperates with NOTch1 to drive the oncogenic transcriptional program in T-cell leukemia

Jin, Q., Martinez, C. A., Arcipowski, K. M., Zhu, Y., Gutierrez-Diaz, B. T., Wang, K. K., Johnson, M. R., Volk, A. G., Wang, F., Wu, J., Grove, C., Wang, H., Sokirniy, I., Thomas, P. M., Goo, Y. A., Abshiru, N. A., Hijiya, N., Peirs, S., Vandamme, N., Berx, G. & 27 others, Goosens, S., Marshall, S. A., Rendleman, E. J., Takahashi, Y. H., Wang, L., Rawat, R., Bartom, E. T., Collings, C. K., Van Vlierberghe, P., Strikoudis, A., Kelly, S., Ueberheide, B., Mantis, C., Kandela, I., Bourquin, J. P., Bornhauser, B., Serafin, V., Bresolin, S., Paganin, M., Accordi, B., Basso, G., Kelleher, N. L., Weinstock, J., Kumar, S., Crispino, J. D., Shilatifard, A. & Ntziachristos, P., Jan 1 2019, In : Clinical Cancer Research. 25, 1, p. 222-239 18 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

Zhang, H., Gutruf, P., Meacham, K., Montana, M. C., Zhao, X., Chiarelli, A. M., Vázquez-Guardado, A., Norris, A., Lu, L., Guo, Q., Xu, C., Wu, Y., Zhao, H., Ning, X., Bai, W., Kandela, I., Haney, C. R., Chanda, D., Gereau, R. W. & Rogers, J. A., Jan 1 2019, In : Science Advances. 5, 3, eaaw0873.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2018

Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo

Serna, V. A., Wu, X., Qiang, W., Thomas, J., Blumenfeld, M. L. & Kurita, T., Jul 2018, In : Endocrine-related cancer. 25, 7, p. 747-759 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Extended intravitreal rabbit eye residence of nanoparticles conjugated with cationic arginine peptides for intraocular drug delivery: In vivo imaging

Melgar-Asensio, I., Kandela, I., Aird, F., Darjatmoko, S. R., de los Rios, C., Sorenson, C. M., Albert, D. M., Sheibani, N. & Henkin, J., Aug 2018, In : Investigative Ophthalmology and Visual Science. 59, 10, p. 4071-4081 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

Bai, W., Yang, H., Ma, Y., Chen, H., Shin, J., Liu, Y., Yang, Q., Kandela, I., Liu, Z., Kang, S. K., Wei, C., Haney, C. R., Brikha, A., Ge, X., Feng, X., Braun, P. V., Huang, Y., Zhou, W. & Rogers, J. A., Aug 9 2018, In : Advanced Materials. 30, 32, 1801584.

Research output: Contribution to journalArticle

20 Scopus citations

Fully implantable optoelectronic systems for battery-free, multimodal operation in neuroscience research

Gutruf, P., Krishnamurthi, V., Vázquez-Guardado, A., Xie, Z., Banks, A., Su, C. J., Xu, Y., Haney, C. R., Waters, E. A., Kandela, I., Krishnan, S. R., Ray, T., Leshock, J. P., Huang, Y., Chanda, D. & Rogers, J. A., Dec 1 2018, In : Nature Electronics. 1, 12, p. 652-660 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

HE4 and eIF3a expression correlates with surgical outcome and overall survival in ovarian cancer patients with secondary cytoreduction

Luo, C. H., Zhao, M., Chen, X. Y., Shahabi, S., Qiang, W., Zeng, L., Wang, J. & Zhou, H. H., Jan 1 2018, In : Journal of Cancer. 9, 14, p. 2472-2479 8 p.

Research output: Contribution to journalArticle

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

Frankowski, K. J., Wang, C., Patnaik, S., Schoenen, F. J., Southall, N., Li, D., Teper, Y., Sun, W., Kandela, I., Hu, D., Dextras, C., Knotts, Z., Bian, Y., Norton, J., Titus, S., Lewandowska, M. A., Wen, Y., Farley, K. I., Griner, L. M., Sultan, J. & 28 others, Meng, Z., Zhou, M., Vilimas, T., Powers, A. S., Kozlov, S., Nagashima, K., Quadri, H. S., Fang, M., Long, C., Khanolkar, O., Chen, W., Kang, J., Huang, H., Chow, E., Goldberg, E., Feldman, C., Xi, R., Kim, H. R., Sahagian, G., Baserga, S. J., Mazar, A., Ferrer, M., Zheng, W., Shilatifard, A., Aubé, J., Rudloff, U., Marugan, J. J. & Huang, S., May 16 2018, In : Science translational medicine. 10, 441, eaap8307.

Research output: Contribution to journalArticle

14 Scopus citations

Pumilio2 regulates synaptic plasticity via translational repression of synaptic receptors in mice

Dong, H., Zhu, M., Meng, L., Ding, Y., Yang, D., Zhang, S., Qiang, W., Fisher, D. W. & Xu, E. Y., Aug 14 2018, In : Oncotarget. 9, 63, p. 32134-32148 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Replication study: Androgen receptor splice variants determine taxane sensitivity in prostate cancer

Shan, X., Danet-Desnoyers, G., Aird, F., Kandela, I., Tsui, R., Perfito, N. & Iorns, E., Jan 1 2018, In : PeerJ. 2018, 4, e4661.

Research output: Contribution to journalArticle

2 Scopus citations

Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma

Tiram, G., Ferber, S., Ofek, P., Eldar-Boock, A., Ben-Shushan, D., Yeini, E., Krivitsky, A., Blatt, R., Almog, N., Henkin, J., Amsalem, O., Yavin, E., Cohen, G., Lazarovici, P., Lee, J. S., Ruppin, E., Milyavsky, M., Grossman, R., Ram, Z., Calderón, M. & 2 others, Haag, R. & Satchi-Fainaro, R., Nov 2018, In : FASEB Journal. 32, 11, p. 5835-5850 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib

Liu, Y., Lou, G., Norton, J. T., Wang, C., Kandela, I., Tang, S., Shank, N. I., Gupta, P., Huang, M., Avram, M. J., Green, R., Mazar, A., Appella, D., Chen, Z. & Huang, S., Jan 1 2017, In : FASEB Journal. 31, 12, p. 5453-5465 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells

Wang, Y. F., Xu, Y. L., Tang, Z. H., Li, T., Zhang, L. L., Chen, X., Lu, J. H., Leung, C. H., Ma, D. L., Qiang, W. A., Wang, Y. T. & Lu, J. J., 2017, In : American Journal of Chinese Medicine. 45, 1, p. 123-136 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models

Ugolkov, A., Qiang, W., Bondarenko, G., Procissi, D., Gaisina, I., James, C. D., Chandler, J., Kozikowski, A., Gunosewoyo, H., O'Halloran, T., Raizer, J. & Mazar, A. P., Aug 2017, In : Translational Oncology. 10, 4, p. 669-678 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro

Zhong, Z. F., Tan, W., Tian, K., Yu, H., Qiang, W. A. & Wang, Y. T., Apr 2017, In : Oncology reports. 37, 4, p. 2016-2024 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome

Ferber, S., Tiram, G., Sousa-Herves, A., Eldar-Boock, A., Krivitsky, A., Scomparin, A., Yeini, E., Ofek, P., Ben-Shushan, D., Vossen, L. I., Licha, K., Grossman, R., Ram, Z., Henkin, J., Ruppin, E., Auslander, N., Haag, R., Calderón, M. & Satchi-Fainaro, R., Oct 4 2017, In : eLife. 6, e25281.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice

Kandela, I. K., McAuliffe, K. J., Cochran, L. E., Barrett, A. G. M., Hoffman, B. M., Mazar, A. P. & Trivedi, E. R., Jul 13 2017, In : ACS Medicinal Chemistry Letters. 8, 7, p. 705-709 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies

Hartlieb, K. J., Ferris, D. P., Holcroft, J. M., Kandela, I., Stern, C. L., Nassar, M. S., Botros, Y. Y. & Stoddart, J. F., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1831-1839 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Furanodiene induces extrinsic and intrinsic apoptosis in doxorubicin-resistant MCF-7 breast cancer cells via NF-κB-independent mechanism

Zhong, Z. F., Yu, H. B., Wang, C. M., Qiang, W. A., Wang, S. P., Zhang, J. M., Yu, H., Cui, L., Wu, T., Li, D. Q. & Wang, Y. T., Sep 14 2017, In : Frontiers in Pharmacology. 8, SEP, 648.

Research output: Contribution to journalArticle

3 Scopus citations

Garcinone e induces apoptosis and inhibits migration and invasion in ovarian cancer cells

Xu, X. H., Liu, Q. Y., Li, T., Liu, J. L., Chen, X., Huang, L., Qiang, W. A., Chen, X., Wang, Y., Lin, L. G. & Lu, J. J., Dec 1 2017, In : Scientific reports. 7, 1, 10718.

Research output: Contribution to journalArticle

13 Scopus citations

Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells

Zhao, G., Wang, Q., Gu, Q., Qiang, W., Wei, J. J., Dong, P., Watari, H., Li, W. & Yue, J., Nov 1 2017, In : Oncotarget. 8, 55, p. 94666-94680 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Plebanek, M. P., Angeloni, N. L., Vinokour, E., Li, J., Henkin, A., Martinez-Marin, D., Filleur, S., Bhowmick, R., Henkin, J., Miller, S. D., Ifergan, I., Lee, Y., Osman, I., Thaxton, C. S. & Volpert, O. V., Dec 1 2017, In : Nature communications. 8, 1, 1319.

Research output: Contribution to journalArticle

80 Scopus citations

Replication study: Discovery and preclinical validation of drug indications using compendia of public gene expression data

Reproducibility Project: Cancer Biology, Jan 19 2017, In : eLife. 6, e17044.

Research output: Contribution to journalArticle

12 Scopus citations

Replication study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

Reproducibility Project: Cancer Biology, Jan 19 2017, In : eLife. 6, e17584.

Research output: Contribution to journalArticle

24 Scopus citations

Replication study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Aird, F., Kandela, I., Mantis, C., Iorns, E., Denis, A., Williams, S. R., Perfito, N. & Errington, T. M., Jan 19 2017, In : eLife. 6, e21253.

Research output: Contribution to journalArticle

19 Scopus citations

Subtype-specific tumor-associated fibroblasts contribute to the pathogenesis of uterine leiomyoma

Wu, X., Serna, V. A., Thomas, J., Qiang, W., Blumenfeld, M. L. & Kurita, T., Dec 15 2017, In : Cancer Research. 77, 24, p. 6891-6901 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Sustaining intravitreal residence with L-arginine peptide-conjugated nanocarriers

Li, H., Liu, W., Sorenson, C. M., Sheibani, N., Albert, D. M., Senanayake, T., Vinogradov, S., Henkin, J. & Zhang, H. F., Oct 2017, In : Investigative Ophthalmology and Visual Science. 58, 12, p. 5142-5150 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells

Hendrix, M. J. C., Kandela, I., Mazar, A. P., Seftor, E. A., Seftor, R. E., Margaryan, N. V., Strizzi, L., Murphy, G. F., Long, G. V. & Scolyer, R. A., Feb 1 2017, In : Laboratory Investigation. 97, 2, p. 176-186 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells

Chen, X., Wu, Q. S., Meng, F. C., Tang, Z. H., Chen, X., Lin, L. G., Chen, P., Qiang, W. A., Wang, Y. T., Zhang, Q. W. & Lu, J. J., Dec 1 2016, In : Phytomedicine. 23, 13, p. 1555-1565 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma

Dong, R., Qiang, W., Guo, H., Xu, X., Kim, J. J., Mazar, A., Kong, B. & Wei, J. J., Sep 21 2016, In : Journal of Hematology and Oncology. 9, 1, 92.

Research output: Contribution to journalArticle

15 Scopus citations

Proteasomal inhibition by ixazomib induces CHK1 and MYC-dependent cell death in T-cell and Hodgkin lymphoma

Ravi, D., Beheshti, A., Abermil, N., Passero, F., Sharma, J., Coyle, M., Kritharis, A., Kandela, I., Hlatky, L., Sitkovsky, M. V., Mazar, A., Gartenhaus, R. B. & Evens, A. M., Jun 1 2016, In : Cancer Research. 76, 11, p. 3319-3331 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars

Dam, D. H. M., Culver, K. S. B., Kandela, I., Lee, R. C., Chandra, K., Lee, H., Mantis, C., Ugolkov, A., Mazar, A. P. & Odom, T. W., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 3, p. 671-679 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection

Swanson, K. I., Clark, P. A., Zhang, R. R., Kandela, I. K., Farhoud, M., Weichert, J. P. & Kuo, J. S., 2015, In : Neurosurgery. 76, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Reproducibility Project: Cancer Biology, Jun 25 2015, In : eLife. 4, JUNE, e07072.

Research output: Contribution to journalArticle

14 Scopus citations

Registered report: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

Reproducibility Project: Cancer Biology, May 22 2015, In : eLife. 4, MAY, p. 1-14 14 p., e06959.

Research output: Contribution to journalArticle

4 Scopus citations

Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data

Reproducibility Project: Cancer Biology, May 5 2015, In : eLife. 4, MAY, p. 1-7 7 p., e06847.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin

Dalva-Aydemir, S., Bajpai, R., Martinez, M., Adekola, K. U. A., Kandela, I., Wei, C., Singhal, S., Koblinski, J. E., Raje, N. S., Rosen, S. T. & Shanmugam, M., Mar 1 2015, In : Clinical Cancer Research. 21, 5, p. 1161-1171 11 p.

Research output: Contribution to journalArticle

45 Scopus citations