CSCB - Center for Sleep and Circadian Biology

Research Output

1993

Photoperiodic responses differ among inbred strains of golden hamsters (Mesocricetus auratus)

Vitaterna, M. H. & Turek, F. W., Jan 1 1993, In : Biology of Reproduction. 49, 3, p. 496-501 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Reduced light sensitivity of the circadian clock in a hypopigmented mouse mutant

Vitaterna, M. H., Wu, J. C., Turek, F. W. & Pinto, L. H., Aug 1 1993, In : Experimental Brain Research. 95, 3, p. 436-442 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
1994

Forward and reverse genetic approaches to behavior in the mouse

Takahashi, J. S., Pinto, L. H. & Vitaterna, M. H., 1994, In : Science. 264, 5166, p. 1724-1733 10 p.

Research output: Contribution to journalArticle

178 Scopus citations

Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior

Vitaterna, M. H., King, D. P., Chang, A. M., Kernhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W. & Takahashi, J. S., Apr 29 1994, In : Science. 264, 5159, p. 719-725 7 p.

Research output: Contribution to journalArticle

1198 Scopus citations

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

Vitaterna, M. H., Jan 1 1994, In : Trends in Genetics. 10, 7, 1 p.

Research output: Contribution to journalComment/debate

1995

Pharmacological and genetic approaches for the study of circadian rhythms in mammals

Turek, F. W., Pinto, L. H., Vitaterna, M. H., Penev, P. D., Zee, P. C. & Takahashi, J. S., Jul 1995, In : Frontiers in Neuroendocrinology. 16, 3, p. 191-223 33 p.

Research output: Contribution to journalArticle

19 Scopus citations
1997

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

Antoch, M. P., Song, E. J., Chang, A. M., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H. & Takahashi, J. S., May 16 1997, In : Cell. 89, 4, p. 655-667 13 p.

Research output: Contribution to journalArticle

523 Scopus citations

Positional cloning of the mouse circadian Clock gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., Turek, F. W. & Takahashi, J. S., May 16 1997, In : Cell. 89, 4, p. 641-653 13 p.

Research output: Contribution to journalArticle

1053 Scopus citations

Rapid photoperiod-induced increase in detectable GnRH mRNA-containing cells in Siberian hamster

Porkka-Heiskanen, T., Khoshaba, N., Scarbrough, K., Urban, J. H., Vitaterna, M. H., Levine, J. E., Turek, F. W. & Horton, T. H., Dec 1 1997, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 273, 6 42-6, p. R2032-R2039

Research output: Contribution to journalArticle

32 Scopus citations

The mouse Clock mutation behaves as an antimorph and maps within the W(19H) deletion, distal of Kit

King, D. P., Vitaterna, M. H., Chang, A. M., Dove, W. F., Pinto, L. H., Turek, F. W. & Takahashi, J. S., Jul 23 1997, In : Genetics. 146, 3, p. 1049-1060 12 p.

Research output: Contribution to journalArticle

120 Scopus citations
1998

Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F2 mice

Valentinuzzi, V. S., Kolker, D. E., Vitaterna, M. H., Shimomura, K., Whiteley, A., Low-Zeddies, S., Turek, F. W., Ferrari, E. A. M., Paylor, R. & Takahashi, J. S., Dec 1 1998, In : Learning and Memory. 5, 4-5, p. 391-403 13 p.

Research output: Contribution to journalArticle

69 Scopus citations

Mammalian circadian autoregulatory loop: A timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

Sangoram, A. M., Saez, L., Antoch, M. P., Gekakis, N., Staknis, D., Whiteley, A., Fruechte, E. M., Vitaterna, M. H., Shimomura, K., King, D. P., Young, M. W., Weitz, C. J. & Takahashi, J. S., Nov 1998, In : Neuron. 21, 5, p. 1101-1113 13 p.

Research output: Contribution to journalArticle

276 Scopus citations

Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses

Thresher, R. J., Vitaterna, M. H., Miyamoto, Y., Kazantsev, A., Hsu, D. S., Petit, C., Selby, C. P., Dawut, L., Smithies, O., Takahashi, J. S. & Sancar, A., Nov 20 1998, In : Science. 282, 5393, p. 1490-1494 5 p.

Research output: Contribution to journalArticle

303 Scopus citations
1999

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., Takahashi, J. S. & Sancar, A., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 12114-12119 6 p.

Research output: Contribution to journalArticle

496 Scopus citations
2000

The circadian Clock mutation alters sleep homeostasis in the mouse

Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H. & Turek, F. W., Nov 1 2000, In : Journal of Neuroscience. 20, 21, p. 8138-8143 6 p.

Research output: Contribution to journalArticle

Open Access
286 Scopus citations
2001

Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Valentinuzzi, V. S., Kolker, D. E., Vitaterna, M. H., Ferrari, E. A. M., Takahashi, J. S. & Turek, F. W., Jan 1 2001, In : Animal Learning and Behavior. 29, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice

Shimomura, K., Low-Zeddies, S. S., King, D. P., Steeves, T. D. L., Whiteley, A., Kushla, J., Zemenides, P. D., Lin, A., Vitaterna, M. H., Churchill, G. A. & Takahashi, J. S., 2001, In : Genome research. 11, 6, p. 959-980 22 p.

Research output: Contribution to journalArticle

184 Scopus citations

Overview of circadian rhythms

Vitaterna, M. H., Takahashi, J. S. & Turek, F. W., Dec 1 2001, In : Alcohol Research and Health. 25, 2, p. 85-93 9 p.

Research output: Contribution to journalArticle

111 Scopus citations
2002

Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: The effect of circadian time, age and genetic background

Lin, L., Wisor, J., Shiba, T., Taheri, S., Yanai, K., Wurts, S., Lin, X., Vitaterna, M., Takahashi, J., Lovenberg, T. W., Koehl, M., Uhl, G., Nishino, S. & Mignot, E., Dec 1 2002, In : Peptides. 23, 12, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2003

Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x fisher 344 cross

Solberg, L. C., Ahmadiyeh, N., Baum, A. E., Vitaterna, M. H., Takahashi, J. S., Turek, F. W. & Redei, E. E., 2003, In : Molecular Psychiatry. 8, 4, p. 423-433 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

A genome end-game: Understanding gene function in the nervous system

Bult, C., Kibbe, W. A., Snoddy, J., Vitaterna, M., Swanson, D., Pretel, S., Li, Y., Hohman, M. M., Rinchik, E., Takahashi, J. S., Frankel, W. N. & Goldowitz, D., May 1 2004, In : Nature Neuroscience. 7, 5, p. 484-485 2 p.

Research output: Contribution to journalShort survey

9 Scopus citations

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice

Kolker, D. E., Vitaterna, M. H., Fruechte, E. M., Takahashi, J. S. & Turek, F. W., Apr 1 2004, In : Neurobiology of Aging. 25, 4, p. 517-523 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Implementing large-scale ENU mutagenesis screens in North America

Clark, A. T., Goldowitz, D., Takahashi, J. S., Vitaterna, M. H., Siepka, S. M., Peters, L. L., Frankel, W. N., Carlson, G. A., Rossant, J., Nadeau, J. H. & Justice, M. J., Sep 1 2004, In : Genetica. 122, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

Goldowitz, D., Frankel, W. N., Takahashi, J. S., Vitaterna, M. H., Bult, C., Kibbe, W. A., Snoddy, J., Li, Y., Pretel, S., Yates, J. & Swanson, D. J., Dec 20 2004, In : Molecular Brain Research. 132, 2, p. 105-115 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus

Pinto, L. H., Vitaterna, M. H., Siepka, S. M., Shimomura, K., Lumayag, S., Baker, M., Fenner, D., Mullins, R. F., Sheffield, V. C., Stone, E. M., Heffron, E. & Takahashi, J. S., Dec 2004, In : Vision Research. 44, 28 SPEC.ISS., p. 3335-3345 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2005

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Mcdearmon, E. L., Fenner, D., Lumayag, S. L., Omura, C., Andrews, A. W., Baker, M., Invergo, B. M., Olvera, M. A., Heffron, E., Mullins, R. F., Sheffield, V. C., Stone, E. M. & Takahashi, J. S., Sep 1 2005, In : Visual Neuroscience. 22, 5, p. 619-629 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice

Brzezinski IV, J. A., Brown, N. L., Tanikawa, A., Bush, R. A., Sieving, P. A., Vitaterna, M. H., Takahashi, J. S. & Glaser, T., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 7, p. 2540-2551 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Molecular Genetic Basis for Mammalian Circadian Rhythms

Vitaterna, M. H., Pinto, L. H. & Turek, F. W., Dec 1 2005, Principles and Practice of Sleep Medicine. Elsevier Inc, p. 363-374 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Regulation of dopaminergic transmission and cocaine reward by the Clock gene

McClung, C. A., Sidiropoulou, K., Vitaterna, M. H., Takahashi, J. S., White, F. J., Cooper, D. C. & Nestler, E. J., Jun 28 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 26, p. 9377-9381 5 p.

Research output: Contribution to journalArticle

349 Scopus citations
2006

A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits

Jiang, P., Kasarskis, A., Winrow, C. J., Renger, J. J. & Turek, F. W., Jan 1 2006, The Genetic Basis of Sleep and Sleep Disorders. Cambridge University Press, p. 104-118 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice

Vitaterna, M. H., Pinto, L. H. & Takahashi, J. S., Apr 1 2006, In : Trends in Neurosciences. 29, 4, p. 233-240 8 p.

Research output: Contribution to journalReview article

39 Scopus citations

The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude

Vitaterna, M. H., Ko, C. H., Chang, A. M., Buhr, E. D., Fruechte, E. M., Schook, A., Antoch, M. P., Turek, F. W. & Takahashi, J. S., Jun 13 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 24, p. 9327-9332 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

Moran, J. L., Bolton, A. D., Tran, P. V., Brown, A., Dwyer, N. D., Manning, D. K., Bjork, B. C., Li, C., Montgomery, K., Siepka, S. M., Vitaterna, M. H., Takahashi, J. S., Wiltshire, T., Kwiatkowski, D. J., Kucherlapati, R. & Beier, D. R., Mar 2006, In : Genome research. 16, 3, p. 436-440 5 p.

Research output: Contribution to journalArticle

82 Scopus citations
2007

Circadian Rhythms, Genetics of

Turek, F. W. & Vitaterna, M. H., Jan 1 2007, Encyclopedia of Stress. Elsevier Inc, p. 508-512 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Balannik, V., McDearmon, E. L., Omura, C., Lumayag, S., Invergo, B. M., Glawe, B., Cantrell, D. R., Inayat, S., Olvera, M. A., Vessey, K. A., McCall, M. A., Maddox, D., Morgans, C. W., Young, B., Pletcher, M. T., Mullins, R. F. & 2 others, Troy, J. B. & Takahashi, J. S., Jan 1 2007, In : Visual Neuroscience. 24, 1, p. 111-123 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Mania-like behavior induced by disruption of CLOCK

Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M. H., Orsulak, P., Takahashi, J. S., Nestler, E. J., Carlezon, W. A. & McClung, C. A., Apr 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 15, p. 6406-6411 6 p.

Research output: Contribution to journalArticle

562 Scopus citations
2009

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H. & Turek, F. W., Nov 2009, In : Obesity. 17, 11, p. 2100-2102 3 p.

Research output: Contribution to journalArticle

518 Scopus citations

Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings

Wisor, J. P., Jiang, P., Striz, M. & O'Hara, B. F., Oct 16 2009, In : Brain research. 1296, p. 46-55 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic analysis of daily physical activity using a mouse chromosome substitution strain

Yang, H. S., Vitaterna, M. H., Laposky, A. D., Shimomura, K. & Turek, F. W., Sep 1 2009, In : Physiological Genomics. 39, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Uncovering the genetic landscape for multiple sleep-wake traits

Winrow, C. J., Williams, D. L., Kasarskis, A., Millstein, J., Laposky, A. D., Yang, H. S., Mrazek, K., Zhou, L., Owens, J. R., Radzicki, D., Preuss, F., Schadt, E. E., Shimomura, K., Vitaterna, M. H., Zhang, C., Koblan, K. S., Regner, J. J. & Turek, F. W., Apr 10 2009, In : PloS one. 4, 4, e5161.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Circadian Clock Genes

Vitaterna, M. H. & Turek, F. W., Nov 1 2010, Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc, p. 141-150 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., Lopez, J. P., Philipson, L. H., Bradfield, C. A., Crosby, S. D., Jebailey, L., Wang, X., Takahashi, J. S. & Bass, J., Jul 29 2010, In : Nature. 466, 7306, p. 627-631 5 p.

Research output: Contribution to journalArticle

837 Scopus citations

Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice

George, M., Rainey, M. A., Naramura, M., Ying, G. G., Harms, D. W., Vitaterna, M. H., Doglio, L., Crawford, S. E., Hess, R. A., Band, V. & Band, H., May 2010, In : Genesis. 48, 5, p. 328-342 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Shimomura, K., Lowrey, P. L., Vitaterna, M. H., Buhr, E. D., Kumar, V., Hanna, P., Omura, C., Izumo, M., Low, S. S., Barrett, R. K., LaRue, S. I., Green, C. B. & Takahashi, J. S., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8399-8403 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome

Jiang, P., Striz, M., Wisor, J. P. & O'Hara, B. F., Jan 1 2011, In : Sleep. 34, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators

Fenner, D., Odili, S., Hong, H. K., Kobayashi, Y., Kohsaka, A., Siepka, S. M., Vitaterna, M. H., Chen, P., Zelent, B., Grimsby, J., Takahashi, J. S., Matschinsky, F. M. & Bass, J., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39560-39572 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake

Millstein, J., Winrow, C. J., Kasarskis, A., Owens, J. R., Zhou, L., Summa, K. C., Fitzpatrick, K., Zhang, B., Vitaterna, M. H., Schadt, E. E., Renger, J. J. & Turek, F. W., Nov 1 2011, In : Sleep. 34, 11, p. 1469-1477 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular neurobiology of circadian rhythms

Turek, F. W. & Vitaterna, M. H., Jan 1 2011, In : Handbook of Clinical Neurology. 99, C, p. 951-961 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological validation of candidate causal sleep genes identified in an N2 cross

Brunner, J. I., Gotter, A. L., Millstein, J., Garson, S., Binns, J., Fox, S. V., Savitz, A. T., Yang, H. S., Fitzpatrick, K., Zhou, L., Owens, J. R., Webber, A. L., Vitaterna, M. H., Kasarskis, A., Uebele, V. N., Turek, F., Renger, J. J. & Winrow, C. J., Dec 1 2011, In : Journal of Neurogenetics. 25, 4, p. 167-181 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse

Arble, D. M., Vitaterna, M. H. & Turek, F. W., Sep 19 2011, In : PloS one. 6, 9, e25079.

Research output: Contribution to journalArticle

29 Scopus citations