CSCB - Center for Sleep and Circadian Biology

Research Output

A genome end-game: Understanding gene function in the nervous system

Bult, C., Kibbe, W. A., Snoddy, J., Vitaterna, M., Swanson, D., Pretel, S., Li, Y., Hohman, M. M., Rinchik, E., Takahashi, J. S., Frankel, W. N. & Goldowitz, D., May 1 2004, In : Nature Neuroscience. 7, 5, p. 484-485 2 p.

Research output: Contribution to journalShort survey

9 Scopus citations

Altered Body Weight Regulation in CK1ϵ Null and tau Mutant Mice on Regular Chow and High Fat Diets

Zhou, L., Summa, K. C., Olker, C., Vitaterna, M. H. & Turek, F. W., Jan 1 2016, In : Genetics Research International. 2016, 4973242.

Research output: Contribution to journalArticle

3 Scopus citations

Altered sleep and affect in the neurotensin receptor 1 knockout mouse

Fitzpatrick, K., Winrow, C. J., Gotter, A. L., Millstein, J., Arbuzova, J., Brunner, J., Kasarskis, A., Vitaterna, M. H., Renger, J. J. & Turek, F. W., Jul 1 2012, In : Sleep. 35, 7, p. 949-956 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

A Systems Approach Identifies Networks and Genes Linking Sleep and Stress: Implications for Neuropsychiatric Disorders

Jiang, P., Scarpa, J. R., Fitzpatrick, K., Losic, B., Gao, V. D., Hao, K., Summa, K. C., Yang, H. S., Zhang, B., Allada, R., Vitaterna, M. H., Turek, F. W. & Kasarskis, A., 2015, In : Cell reports. 11, 5, p. 835-848 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits

Jiang, P., Kasarskis, A., Winrow, C. J., Renger, J. J. & Turek, F. W., Jan 1 2006, The Genetic Basis of Sleep and Sleep Disorders. Cambridge University Press, p. 104-118 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F2 mice

Valentinuzzi, V. S., Kolker, D. E., Vitaterna, M. H., Shimomura, K., Whiteley, A., Low-Zeddies, S., Turek, F. W., Ferrari, E. A. M., Paylor, R. & Takahashi, J. S., Dec 1 1998, In : Learning and Memory. 5, 4-5, p. 391-403 13 p.

Research output: Contribution to journalArticle

69 Scopus citations

Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome

Jiang, P., Striz, M., Wisor, J. P. & O'Hara, B. F., Jan 1 2011, In : Sleep. 34, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response

Kumar, V., Kim, K., Joseph, C., Kourrich, S., Yoo, S. H., Huang, H. C., Vitaterna, M. H., De Villena, F. P. M., Churchill, G., Bonci, A. & Takahashi, J. S., Jan 1 2013, In : Science. 342, 6165, p. 1508-1512 5 p.

Research output: Contribution to journalArticle

94 Scopus citations

Changes in Gene Expression

O'Hara, B. F. & Jiang, P., Jan 1 2013, Encyclopedia of Sleep. Elsevier Inc, p. 246-250 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon

Summa, K. C., Jiang, P., Fitzpatrick, K., Voigt, R. M., Bowers, S. J., Forsyth, C. B., Vitaterna, M. H., Keshavarzian, A. & Turek, F. W., Oct 2015, In : Alcoholism: Clinical and Experimental Research. 39, 10, p. 1917-1929 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Circadian Clock Genes

Vitaterna, M. H. & Turek, F. W., Nov 1 2010, Principles and Practice of Sleep Medicine: Fifth Edition. Elsevier Inc, p. 141-150 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Circadian disorganization alters intestinal microbiota

Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W. & Keshavarzian, A., May 21 2014, In : PloS one. 9, 5, e97500.

Research output: Contribution to journalArticle

162 Scopus citations

Circadian Rhythms, Genetics of

Turek, F. W. & Vitaterna, M. H., Jan 1 2007, Encyclopedia of Stress. Elsevier Inc, p. 508-512 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Circadian rhythms in neuroendocrine systems

Arble, D. M., Copinschi, G., Vitaterna, M. H., Van Cauter, E. & Turek, F. W., Dec 1 2012, Handbook of Neuroendocrinology. Elsevier Inc, p. 271-305 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H. & Turek, F. W., Nov 2009, In : Obesity. 17, 11, p. 2100-2102 3 p.

Research output: Contribution to journalArticle

518 Scopus citations

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

Scarpa, J. R., Jiang, P., Gao, V. D., Fitzpatrick, K., Millstein, J., Olker, C., Gotter, A., Winrow, C. J., Renger, J. J., Kasarskis, A., Turek, F. W. & Vitaterna, M. H., Jul 25 2018, In : Science Advances. 4, 7, eaat1294.

Research output: Contribution to journalArticle

2 Scopus citations

Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids

Bryant, C. D., Parker, C. C., Zhou, L., Olker, C., Chandrasekaran, R. Y., Wager, T. T., Bolivar, V. J., Loudon, A. S., Vitaterna, M. H., Turek, F. W. & Palmer, A. A., Mar 1 2012, In : Neuropsychopharmacology. 37, 4, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x fisher 344 cross

Solberg, L. C., Ahmadiyeh, N., Baum, A. E., Vitaterna, M. H., Takahashi, J. S., Turek, F. W. & Redei, E. E., 2003, In : Molecular Psychiatry. 8, 4, p. 423-433 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., Takahashi, J. S. & Sancar, A., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 12114-12119 6 p.

Research output: Contribution to journalArticle

496 Scopus citations

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

Summa, K. C., Voigt, R. M., Forsyth, C. B., Shaikh, M., Cavanaugh, K., Tang, Y., Vitaterna, M. H., Song, S., Turek, F. W. & Keshavarzian, A., Jun 18 2013, In : PloS one. 8, 6, e67102.

Research output: Contribution to journalArticle

116 Scopus citations

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., Lopez, J. P., Philipson, L. H., Bradfield, C. A., Crosby, S. D., Jebailey, L., Wang, X., Takahashi, J. S. & Bass, J., Jul 29 2010, In : Nature. 466, 7306, p. 627-631 5 p.

Research output: Contribution to journalArticle

837 Scopus citations

Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice

Jiang, P., Franklin, K. M., Duncan, M. J., O'Hara, B. F. & Wisor, J. P., Oct 1 2012, In : Sleep. 35, 10, p. 1385-1394 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Dopamine pathway imbalance in mice lacking Magel2, a Prader-Willi syndrome candidate gene

Luck, C., Vitaterna, M. H. & Wevrick, R., Aug 1 2016, In : Behavioral Neuroscience. 130, 4, p. 448-459 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Valentinuzzi, V. S., Kolker, D. E., Vitaterna, M. H., Ferrari, E. A. M., Takahashi, J. S. & Turek, F. W., Jan 1 2001, In : Animal Learning and Behavior. 29, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice

Kolker, D. E., Vitaterna, M. H., Fruechte, E. M., Takahashi, J. S. & Turek, F. W., Apr 1 2004, In : Neurobiology of Aging. 25, 4, p. 517-523 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings

Wisor, J. P., Jiang, P., Striz, M. & O'Hara, B. F., Oct 16 2009, In : Brain research. 1296, p. 46-55 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice

George, M., Rainey, M. A., Naramura, M., Ying, G. G., Harms, D. W., Vitaterna, M. H., Doglio, L., Crawford, S. E., Hess, R. A., Band, V. & Band, H., May 2010, In : Genesis. 48, 5, p. 328-342 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

Kc, R., Li, X., Voigt, R. M., Ellman, M. B., Summa, K. C., Vitaterna, M. H., Keshavarizian, A., Turek, F. W., Meng, Q. J., Stein, G. S., van Wijnen, A. J., Chen, D., Forsyth, C. B. & Im, H. J., Sep 1 2015, In : Journal of Cellular Physiology. 230, 9, p. 2174-2183 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Environmental perturbation of the Circadian clock disrupts pregnancy in the mouse

Summa, K. C., Vitaterna, M. H. & Turek, F. W., May 23 2012, In : PloS one. 7, 5, e37668.

Research output: Contribution to journalArticle

53 Scopus citations

Forward and reverse genetic approaches to behavior in the mouse

Takahashi, J. S., Pinto, L. H. & Vitaterna, M. H., 1994, In : Science. 264, 5166, p. 1724-1733 10 p.

Research output: Contribution to journalArticle

178 Scopus citations

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

Antoch, M. P., Song, E. J., Chang, A. M., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H. & Takahashi, J. S., May 16 1997, In : Cell. 89, 4, p. 655-667 13 p.

Research output: Contribution to journalArticle

523 Scopus citations

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Mcdearmon, E. L., Fenner, D., Lumayag, S. L., Omura, C., Andrews, A. W., Baker, M., Invergo, B. M., Olvera, M. A., Heffron, E., Mullins, R. F., Sheffield, V. C., Stone, E. M. & Takahashi, J. S., Sep 1 2005, In : Visual Neuroscience. 22, 5, p. 619-629 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Balannik, V., McDearmon, E. L., Omura, C., Lumayag, S., Invergo, B. M., Glawe, B., Cantrell, D. R., Inayat, S., Olvera, M. A., Vessey, K. A., McCall, M. A., Maddox, D., Morgans, C. W., Young, B., Pletcher, M. T., Mullins, R. F. & 2 others, Troy, J. B. & Takahashi, J. S., Jan 1 2007, In : Visual Neuroscience. 24, 1, p. 111-123 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators

Fenner, D., Odili, S., Hong, H. K., Kobayashi, Y., Kohsaka, A., Siepka, S. M., Vitaterna, M. H., Chen, P., Zelent, B., Grimsby, J., Takahashi, J. S., Matschinsky, F. M. & Bass, J., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39560-39572 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic analysis of daily physical activity using a mouse chromosome substitution strain

Yang, H. S., Vitaterna, M. H., Laposky, A. D., Shimomura, K. & Turek, F. W., Sep 1 2009, In : Physiological Genomics. 39, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetics of Circadian Rhythms

Vitaterna, M. H., Shimomura, K. & Jiang, P., Aug 2019, In : Neurologic clinics. 37, 3, p. 487-504 18 p.

Research output: Contribution to journalReview article

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Shimomura, K., Lowrey, P. L., Vitaterna, M. H., Buhr, E. D., Kumar, V., Hanna, P., Omura, C., Izumo, M., Low, S. S., Barrett, R. K., LaRue, S. I., Green, C. B. & Takahashi, J. S., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8399-8403 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice

Shimomura, K., Low-Zeddies, S. S., King, D. P., Steeves, T. D. L., Whiteley, A., Kushla, J., Zemenides, P. D., Lin, A., Vitaterna, M. H., Churchill, G. A. & Takahashi, J. S., 2001, In : Genome research. 11, 6, p. 959-980 22 p.

Research output: Contribution to journalArticle

184 Scopus citations

High-resolution mapping of a novel genetic locus regulating voluntary physical activity in mice

Yang, H. S., Shimomura, K., Vitaterna, M. H. & Turek, F. W., Feb 1 2012, In : Genes, Brain and Behavior. 11, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake

Millstein, J., Winrow, C. J., Kasarskis, A., Owens, J. R., Zhou, L., Summa, K. C., Fitzpatrick, K., Zhang, B., Vitaterna, M. H., Schadt, E. E., Renger, J. J. & Turek, F. W., Nov 1 2011, In : Sleep. 34, 11, p. 1469-1477 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Implementing large-scale ENU mutagenesis screens in North America

Clark, A. T., Goldowitz, D., Takahashi, J. S., Vitaterna, M. H., Siepka, S. M., Peters, L. L., Frankel, W. N., Carlson, G. A., Rossant, J., Nadeau, J. H. & Justice, M. J., Sep 1 2004, In : Genetica. 122, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice

Vitaterna, M. H., Pinto, L. H. & Takahashi, J. S., Apr 1 2006, In : Trends in Neurosciences. 29, 4, p. 233-240 8 p.

Research output: Contribution to journalReview article

39 Scopus citations

Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

Goldowitz, D., Frankel, W. N., Takahashi, J. S., Vitaterna, M. H., Bult, C., Kibbe, W. A., Snoddy, J., Li, Y., Pretel, S., Yates, J. & Swanson, D. J., Dec 20 2004, In : Molecular Brain Research. 132, 2, p. 105-115 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Light/dark shifting promotes alcohol-induced colon carcinogenesis: Possible role of intestinal inflammatory milieu and microbiota

Bishehsari, F., Saadalla, A., Khazaie, K., Engen, P. A., Voigt, R. M., Shetuni, B. B., Forsyth, C., Shaikh, M., Vitaterna, M. H., Turek, F. & Keshavarzian, A., Dec 2 2016, In : International journal of molecular sciences. 17, 12, 2017.

Research output: Contribution to journalArticle

24 Scopus citations

Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice

Brzezinski IV, J. A., Brown, N. L., Tanikawa, A., Bush, R. A., Sieving, P. A., Vitaterna, M. H., Takahashi, J. S. & Glaser, T., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 7, p. 2540-2551 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Mammalian circadian autoregulatory loop: A timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

Sangoram, A. M., Saez, L., Antoch, M. P., Gekakis, N., Staknis, D., Whiteley, A., Fruechte, E. M., Vitaterna, M. H., Shimomura, K., King, D. P., Young, M. W., Weitz, C. J. & Takahashi, J. S., Nov 1998, In : Neuron. 21, 5, p. 1101-1113 13 p.

Research output: Contribution to journalArticle

276 Scopus citations

Mania-like behavior induced by disruption of CLOCK

Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M. H., Orsulak, P., Takahashi, J. S., Nestler, E. J., Carlezon, W. A. & McClung, C. A., Apr 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 15, p. 6406-6411 6 p.

Research output: Contribution to journalArticle

562 Scopus citations

Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: The effect of circadian time, age and genetic background

Lin, L., Wisor, J., Shiba, T., Taheri, S., Yanai, K., Wurts, S., Lin, X., Vitaterna, M., Takahashi, J., Lovenberg, T. W., Koehl, M., Uhl, G., Nishino, S. & Mignot, E., Dec 1 2002, In : Peptides. 23, 12, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Molecular Genetic Basis for Mammalian Circadian Rhythms

Vitaterna, M. H., Pinto, L. H. & Turek, F. W., Dec 1 2005, Principles and Practice of Sleep Medicine. Elsevier Inc, p. 363-374 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Molecular neurobiology of circadian rhythms

Turek, F. W. & Vitaterna, M. H., Jan 1 2011, In : Handbook of Clinical Neurology. 99, C, p. 951-961 11 p.

Research output: Contribution to journalArticle

2 Scopus citations