CSCB - Center for Sleep and Circadian Biology

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2020

Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome

Bowers, S. J., Vargas, F., González, A., He, S., Jiang, P., Dorrestein, P. C., Knight, R., Wright, K. P., Lowry, C. A., Fleshner, M., Vitaterna, M. H. & Turek, F. W., 2020, In : PloS one. 15, 2, e0229001.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

NMDAR activation regulates the daily rhythms of sleep and mood

Burgdorf, J. S., Vitaterna, M. H., Olker, C. J., Song, E. J., Christian, E. P., Sørensen, L., Turek, F. W., Madsen, T. M., Khan, M. A., Kroes, R. A. & Moskal, J. R., Oct 1 2019, In : Sleep. 42, 10, zsz135.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
3 Scopus citations

Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight

Jiang, P., Green, S. J., Chlipala, G. E., Turek, F. W. & Vitaterna, M. H., Aug 9 2019, In : Microbiome. 7, 1, 113.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The NASA twins study: A multidimensional analysis of a year-long human spaceflight

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A. & 62 others, Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. & Turek, F. W., 2019, In : Science. 364, 6436, eaau8650.

Research output: Contribution to journalArticle

97 Scopus citations

Trait-like vulnerability of higher-order cognition and ability to maintain wakefulness during combined sleep restriction and circadian misalignment

Sprecher, K. E., Ritchie, H. K., Burke, T. M., Depner, C. M., Smits, A. N., Dorrestein, P. C., Fleshner, M., Knight, R., Lowry, C. A., Turek, F. W., Vitaterna, M. H. & Wright, K. P., Aug 1 2019, In : Sleep. 42, 8, zsz113.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

Scarpa, J. R., Jiang, P., Gao, V. D., Fitzpatrick, K., Millstein, J., Olker, C., Gotter, A., Winrow, C. J., Renger, J. J., Kasarskis, A., Turek, F. W. & Vitaterna, M. H., Jul 25 2018, In : Science Advances. 4, 7, eaat1294.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations
2016

Altered Body Weight Regulation in CK1ϵ Null and tau Mutant Mice on Regular Chow and High Fat Diets

Zhou, L., Summa, K. C., Olker, C., Vitaterna, M. H. & Turek, F. W., Jan 1 2016, In : Genetics Research International. 2016, 4973242.

Research output: Contribution to journalArticle

3 Scopus citations

Dopamine pathway imbalance in mice lacking Magel2, a Prader-Willi syndrome candidate gene

Luck, C., Vitaterna, M. H. & Wevrick, R., Aug 1 2016, In : Behavioral Neuroscience. 130, 4, p. 448-459 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Light/dark shifting promotes alcohol-induced colon carcinogenesis: Possible role of intestinal inflammatory milieu and microbiota

Bishehsari, F., Saadalla, A., Khazaie, K., Engen, P. A., Voigt, R. M., Shetuni, B. B., Forsyth, C., Shaikh, M., Vitaterna, M. H., Turek, F. & Keshavarzian, A., Dec 2 2016, In : International journal of molecular sciences. 17, 12, 2017.

Research output: Contribution to journalArticle

24 Scopus citations

Multiple classifier systems for automatic sleep scoring in mice

Gao, V., Turek, F. & Vitaterna, M., May 1 2016, In : Journal of Neuroscience Methods. 264, p. 33-39 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Night workers with circadian misalignment are susceptible to alcohol-induced intestinal hyperpermeability with social drinking

Swanson, G. R., Gorenz, A., Shaikh, M., Desai, V., Kaminsky, T., van Den Berg, J., Murphy, T., Raeisi, S., Fogg, L., Vitaterna, M. H., Forsyth, C., Turek, F., Burgess, H. J. & Keshavarzian, A., Jul 1 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 1, p. G192-G201

Research output: Contribution to journalArticle

27 Scopus citations

Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease

Scarpa, J. R., Jiang, P., Losic, B., Readhead, B., Gao, V. D., Dudley, J. T., Vitaterna, M. H., Turek, F. W. & Kasarskis, A., Jul 2016, In : PLoS genetics. 12, 7, e1006137.

Research output: Contribution to journalArticle

11 Scopus citations

The Circadian Clock Mutation Promotes Intestinal Dysbiosis

Voigt, R. M., Summa, K. C., Forsyth, C. B., Green, S. J., Engen, P., Naqib, A., Vitaterna, M. H., Turek, F. W. & Keshavarzian, A., Feb 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 2, p. 335-347 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
2015

A Systems Approach Identifies Networks and Genes Linking Sleep and Stress: Implications for Neuropsychiatric Disorders

Jiang, P., Scarpa, J. R., Fitzpatrick, K., Losic, B., Gao, V. D., Hao, K., Summa, K. C., Yang, H. S., Zhang, B., Allada, R., Vitaterna, M. H., Turek, F. W. & Kasarskis, A., Jan 1 2015, In : Cell reports. 11, 5, p. 835-848 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon

Summa, K. C., Jiang, P., Fitzpatrick, K., Voigt, R. M., Bowers, S. J., Forsyth, C. B., Vitaterna, M. H., Keshavarzian, A. & Turek, F. W., Oct 2015, In : Alcoholism: Clinical and Experimental Research. 39, 10, p. 1917-1929 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

Kc, R., Li, X., Voigt, R. M., Ellman, M. B., Summa, K. C., Vitaterna, M. H., Keshavarizian, A., Turek, F. W., Meng, Q. J., Stein, G. S., van Wijnen, A. J., Chen, D., Forsyth, C. B. & Im, H. J., Sep 1 2015, In : Journal of Cellular Physiology. 230, 9, p. 2174-2183 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet

Kc, R., Li, X., Forsyth, C. B., Voigt, R. M., Summa, K. C., Vitaterna, M. H., Tryniszewska, B., Keshavarzian, A., Turek, F. W., Meng, Q. J. & Im, H. J., Nov 20 2015, In : Scientific reports. 5, 16896.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Circadian disorganization alters intestinal microbiota

Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W. & Keshavarzian, A., May 21 2014, In : PloS one. 9, 5, e97500.

Research output: Contribution to journalArticle

159 Scopus citations

The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice

Zhou, L., Bryant, C. D., Loudon, A., Palmer, A. A., Vitaterna, M. H. & Turek, F. W., Apr 1 2014, In : Sleep. 37, 4, p. 785-793 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Validation of video motion-detection scoring of forced swim test in mice

Gao, V., Vitaterna, M. H. & Turek, F. W., Sep 30 2014, In : Journal of Neuroscience Methods. 235, p. 59-64 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response

Kumar, V., Kim, K., Joseph, C., Kourrich, S., Yoo, S. H., Huang, H. C., Vitaterna, M. H., De Villena, F. P. M., Churchill, G., Bonci, A. & Takahashi, J. S., Jan 1 2013, In : Science. 342, 6165, p. 1508-1512 5 p.

Research output: Contribution to journalArticle

93 Scopus citations

Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation

Summa, K. C., Voigt, R. M., Forsyth, C. B., Shaikh, M., Cavanaugh, K., Tang, Y., Vitaterna, M. H., Song, S., Turek, F. W. & Keshavarzian, A., Jun 18 2013, In : PloS one. 8, 6, e67102.

Research output: Contribution to journalArticle

112 Scopus citations

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

Shimomura, K., Kumar, V., Koike, N., Kim, T. K., Chong, J., Buhr, E. D., Whiteley, A. R., Low, S. S., Omura, C., Fenner, D., Owens, J. R., Richards, M., Yoo, S. H., Hong, H. K., Vitaterna, M. H., Bass, J., Pletcher, M. T., Wiltshire, T., Hogenesch, J., Lowrey, P. L. & 1 others, Takahashi, J. S., Apr 9 2013, In : eLife. 2013, 2, e00426.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Altered sleep and affect in the neurotensin receptor 1 knockout mouse

Fitzpatrick, K., Winrow, C. J., Gotter, A. L., Millstein, J., Arbuzova, J., Brunner, J., Kasarskis, A., Vitaterna, M. H., Renger, J. J. & Turek, F. W., Jul 1 2012, In : Sleep. 35, 7, p. 949-956 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids

Bryant, C. D., Parker, C. C., Zhou, L., Olker, C., Chandrasekaran, R. Y., Wager, T. T., Bolivar, V. J., Loudon, A. S., Vitaterna, M. H., Turek, F. W. & Palmer, A. A., Mar 1 2012, In : Neuropsychopharmacology. 37, 4, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice

Jiang, P., Franklin, K. M., Duncan, M. J., O'Hara, B. F. & Wisor, J. P., Oct 1 2012, In : Sleep. 35, 10, p. 1385-1394 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Environmental perturbation of the Circadian clock disrupts pregnancy in the mouse

Summa, K. C., Vitaterna, M. H. & Turek, F. W., May 23 2012, In : PloS one. 7, 5, e37668.

Research output: Contribution to journalArticle

53 Scopus citations

High-resolution mapping of a novel genetic locus regulating voluntary physical activity in mice

Yang, H. S., Shimomura, K., Vitaterna, M. H. & Turek, F. W., Feb 1 2012, In : Genes, Brain and Behavior. 11, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome

Jiang, P., Striz, M., Wisor, J. P. & O'Hara, B. F., Jan 1 2011, In : Sleep. 34, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators

Fenner, D., Odili, S., Hong, H. K., Kobayashi, Y., Kohsaka, A., Siepka, S. M., Vitaterna, M. H., Chen, P., Zelent, B., Grimsby, J., Takahashi, J. S., Matschinsky, F. M. & Bass, J., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39560-39572 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of causal genes, networks, and transcriptional regulators of REM sleep and wake

Millstein, J., Winrow, C. J., Kasarskis, A., Owens, J. R., Zhou, L., Summa, K. C., Fitzpatrick, K., Zhang, B., Vitaterna, M. H., Schadt, E. E., Renger, J. J. & Turek, F. W., Nov 1 2011, In : Sleep. 34, 11, p. 1469-1477 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular neurobiology of circadian rhythms

Turek, F. W. & Vitaterna, M. H., Jan 1 2011, In : Handbook of Clinical Neurology. 99, C, p. 951-961 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological validation of candidate causal sleep genes identified in an N2 cross

Brunner, J. I., Gotter, A. L., Millstein, J., Garson, S., Binns, J., Fox, S. V., Savitz, A. T., Yang, H. S., Fitzpatrick, K., Zhou, L., Owens, J. R., Webber, A. L., Vitaterna, M. H., Kasarskis, A., Uebele, V. N., Turek, F., Renger, J. J. & Winrow, C. J., Dec 1 2011, In : Journal of Neurogenetics. 25, 4, p. 167-181 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse

Arble, D. M., Vitaterna, M. H. & Turek, F. W., Sep 19 2011, In : PloS one. 6, 9, e25079.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., Lopez, J. P., Philipson, L. H., Bradfield, C. A., Crosby, S. D., Jebailey, L., Wang, X., Takahashi, J. S. & Bass, J., Jul 29 2010, In : Nature. 466, 7306, p. 627-631 5 p.

Research output: Contribution to journalArticle

829 Scopus citations

Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice

George, M., Rainey, M. A., Naramura, M., Ying, G. G., Harms, D. W., Vitaterna, M. H., Doglio, L., Crawford, S. E., Hess, R. A., Band, V. & Band, H., May 1 2010, In : Genesis. 48, 5, p. 328-342 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway

Shimomura, K., Lowrey, P. L., Vitaterna, M. H., Buhr, E. D., Kumar, V., Hanna, P., Omura, C., Izumo, M., Low, S. S., Barrett, R. K., LaRue, S. I., Green, C. B. & Takahashi, J. S., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8399-8403 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H. & Turek, F. W., Nov 1 2009, In : Obesity. 17, 11, p. 2100-2102 3 p.

Research output: Contribution to journalArticle

514 Scopus citations

Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings

Wisor, J. P., Jiang, P., Striz, M. & O'Hara, B. F., Oct 16 2009, In : Brain research. 1296, p. 46-55 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic analysis of daily physical activity using a mouse chromosome substitution strain

Yang, H. S., Vitaterna, M. H., Laposky, A. D., Shimomura, K. & Turek, F. W., Sep 1 2009, In : Physiological Genomics. 39, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Uncovering the genetic landscape for multiple sleep-wake traits

Winrow, C. J., Williams, D. L., Kasarskis, A., Millstein, J., Laposky, A. D., Yang, H. S., Mrazek, K., Zhou, L., Owens, J. R., Radzicki, D., Preuss, F., Schadt, E. E., Shimomura, K., Vitaterna, M. H., Zhang, C., Koblan, K. S., Regner, J. J. & Turek, F. W., Apr 10 2009, In : PloS one. 4, 4, e5161.

Research output: Contribution to journalArticle

33 Scopus citations
2007

Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Balannik, V., McDearmon, E. L., Omura, C., Lumayag, S., Invergo, B. M., Glawe, B., Cantrell, D. R., Inayat, S., Olvera, M. A., Vessey, K. A., McCall, M. A., Maddox, D., Morgans, C. W., Young, B., Pletcher, M. T., Mullins, R. F. & 2 others, Troy, J. B. & Takahashi, J. S., Jan 1 2007, In : Visual Neuroscience. 24, 1, p. 111-123 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Mania-like behavior induced by disruption of CLOCK

Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M. H., Orsulak, P., Takahashi, J. S., Nestler, E. J., Carlezon, W. A. & McClung, C. A., Apr 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 15, p. 6406-6411 6 p.

Research output: Contribution to journalArticle

560 Scopus citations
2006

The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude

Vitaterna, M. H., Ko, C. H., Chang, A. M., Buhr, E. D., Fruechte, E. M., Schook, A., Antoch, M. P., Turek, F. W. & Takahashi, J. S., Jun 13 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 24, p. 9327-9332 6 p.

Research output: Contribution to journalArticle

163 Scopus citations

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

Moran, J. L., Bolton, A. D., Tran, P. V., Brown, A., Dwyer, N. D., Manning, D. K., Bjork, B. C., Li, C., Montgomery, K., Siepka, S. M., Vitaterna, M. H., Takahashi, J. S., Wiltshire, T., Kwiatkowski, D. J., Kucherlapati, R. & Beier, D. R., Mar 2006, In : Genome research. 16, 3, p. 436-440 5 p.

Research output: Contribution to journalArticle

82 Scopus citations
2005

Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse

Pinto, L. H., Vitaterna, M. H., Shimomura, K., Siepka, S. M., Mcdearmon, E. L., Fenner, D., Lumayag, S. L., Omura, C., Andrews, A. W., Baker, M., Invergo, B. M., Olvera, M. A., Heffron, E., Mullins, R. F., Sheffield, V. C., Stone, E. M. & Takahashi, J. S., Sep 1 2005, In : Visual Neuroscience. 22, 5, p. 619-629 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice

Brzezinski IV, J. A., Brown, N. L., Tanikawa, A., Bush, R. A., Sieving, P. A., Vitaterna, M. H., Takahashi, J. S. & Glaser, T., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 7, p. 2540-2551 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of dopaminergic transmission and cocaine reward by the Clock gene

McClung, C. A., Sidiropoulou, K., Vitaterna, M. H., Takahashi, J. S., White, F. J., Cooper, D. C. & Nestler, E. J., Jun 28 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 26, p. 9377-9381 5 p.

Research output: Contribution to journalArticle

346 Scopus citations