Research Output 1984 2019

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2019

Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors

Deibler, K. K., Schiltz, G. E., Clutter, M., Mishra, R. K., Vagadia, P. P., O'Connor, M., George, M. D., Gordon, R., Fowler, G., Bergan, R. & Scheidt, K. A., Mar 22 2019, In : ChemMedChem. 14, 6, p. 615-620 6 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase 4
Benzoic Acid
Molecular modeling
Oncology
p38 Mitogen-Activated Protein Kinases

Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules

Paxman, J. J., Lo, A. W., Sullivan, M. J., Panjikar, S., Kuiper, M., Whitten, A. E., Wang, G., Luan, C-H., Moriel, D. G., Tan, L., Peters, K. M., Phan, M. D., Gee, C. L., Ulett, G. C., Schembri, M. A. & Heras, B., Dec 1 2019, In : Nature communications. 10, 1, 1967.

Research output: Contribution to journalArticle

Open Access
Bacterial Adhesins
Macromolecules
macromolecules
proteins
infectious diseases
2018
5 Citations (Scopus)

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

Patel, D., Roy, A., Kundu, M., Jana, M., Luan, C. H., Gonzalez, F. J. & Pahan, K., Jul 31 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7408-E7417

Research output: Contribution to journalArticle

PPAR alpha
Aspirin
Ligands
Cyclic AMP Response Element-Binding Protein
Dendritic Spines
2 Citations (Scopus)

Selective disruption of TLR2/MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

Rangasamy, S. B., Jana, M., Roy, A., Corbett, G. T., Kundu, M., Chandra, S., Mondal, S., Dasarathi, S., Mufson, E. J., Mishra, R. K., Luan, C-H., Bennett, D. A. & Pahan, K., Jul 10 2018, In : The Journal of clinical investigation.

Research output: Contribution to journalArticle

Pathology
Inflammation
Peptides
Alzheimer Disease
Hippocampus
2017
2 Citations (Scopus)

A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family

Deibler, K. K., Mishra, R. K., Clutter, M., Antanasijevic, A., Bergan, R., Caffrey, M. & Scheidt, K. A., May 19 2017, In : ACS chemical biology. 12, 5, p. 1245-1256 12 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases
Oncology
p38 Mitogen-Activated Protein Kinases
1 Citation (Scopus)

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

Strickland, M., Ehrlich, L. S., Watanabe, S., Khan, M., Strub, M. P., Luan, C. H., Powell, M. D., Leis, J., Tjandra, N. & Carter, C. A., Dec 1 2017, In : Nature Communications. 8, 1, 1391.

Research output: Contribution to journalArticle

human immunodeficiency virus
Ubiquitin
inhibitors
HIV-1
assembly
2016
1 Citation (Scopus)

A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells

Jolly, A. L., Luan, C-H., Dusel, B. E., Dunne, S. F., Winding, M., Dixit, V. J., Robins, C., Saluk, J. L., Logan, D. J., Carpenter, A. E., Sharma, M., Dean, D., Cohen, A. R. & Gelfand, V. I., Jan 26 2016, In : Cell Reports. 14, 3, p. 611-620 10 p.

Research output: Contribution to journalArticle

RNA Interference
Lysosomes
Microtubules
Drosophila
Genes
7 Citations (Scopus)

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C-H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Penicillin-Binding Proteins
Microbial Drug Resistance
Mycobacterium tuberculosis
Penicillin V

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Manjasetty, B. A., Halavaty, A. S., Luan, C-H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., Jun 1 2016, In : Data in Brief. 7, p. 537-539 3 p.

Research output: Contribution to journalArticle

Salmonella enterica
Hot Temperature
Fluorescence
Ligands
Fluorescence Polarization
19 Citations (Scopus)

Identification and characterization of PPARα ligands in the hippocampus

Roy, A., Kundu, M., Jana, M., Mishra, R. K., Yung, Y., Luan, C. H., Gonzalez, F. J. & Pahan, K., Dec 1 2016, In : Nature Chemical Biology. 12, 12, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hippocampus
Ligands
Neurons
Butyrates
3 Citations (Scopus)

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity

Manjasetty, B. A., Halavaty, A. S., Luan, C-H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., 2016, In : Journal of Structural Biology. Available online

Research output: Contribution to journalArticle

Binding Sites
Pharmaceutical Preparations
Hydrogen
Ligands
Salmonella enterica
2 Citations (Scopus)

Method for identifying small molecule inhibitors of the protein-protein interaction between HCN1 and TRIP8b

Han, Y., Lyman, K. A., Clutter, M., Schiltz, G. E., Ismail, Q. A., Cheng, X., Luan, C. H. & Chetkovich, D. M., Nov 11 2016, In : Journal of Visualized Experiments. 2016, 117, e54540.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Cyclic Nucleotides
Proteins
Molecules
Neurons
13 Citations (Scopus)

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Mar 18 2016, In : Nature Communications. 7, 11000.

Research output: Contribution to journalArticle

Signal transduction
staphylococcus
Staphylococcus aureus
Signal Transduction
Phosphotransferases
7 Citations (Scopus)

The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia

Huang, W., Luan, C. H., Hjort, E. E., Bei, L., Mishra, R., Sakamoto, K. M., Platanias, L. C. & Eklund, E. A., Jul 1 2016, In : Leukemia. 30, 7, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphoric Monoester Hydrolases
Protein-Tyrosine Kinases
Leukemia
Stem Cells
2015
59 Citations (Scopus)

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., Luan, C-H., Gonzalez, F. J. & Pahan, K., Aug 4 2015, In : Cell Metabolism. 22, 2, p. 253-265 13 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Peroxisome Proliferator-Activated Receptors
Nerve Growth Factors
Up-Regulation
Brain
11 Citations (Scopus)

Identification of small-molecule inhibitors of hyperpolarization-activated cyclic nucleotide-gated channels

Han, Y., Lyman, K., Clutter, M., Schiltz, G. E., Ismail, Q. A., Prados, D. B., Luan, C. H. & Chetkovich, D. M., Oct 22 2015, In : Journal of Biomolecular Screening. 20, 9, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Cyclic Nucleotides
Assays
Molecules
Fluorescence Polarization
57 Citations (Scopus)

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Wang, J., Luo, C., Shan, C., You, Q., Lu, J., Elf, S., Zhou, Y., Wen, Y., Vinkenborg, J. L., Fan, J., Kang, H., Lin, R., Han, D., Xie, Y., Karpus, J., Chen, S., Ouyang, S., Luan, C-H., Zhang, N., Ding, H. & 5 others, Merkx, M., Liu, H., Chen, J., Jiang, H. & He, C., Dec 1 2015, In : Nature chemistry. 7, 12, p. 968-979 12 p.

Research output: Contribution to journalArticle

Cell proliferation
Copper
Molecules
Adenosinetriphosphate
Adenosine Triphosphate
18 Citations (Scopus)

Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

Wilcox, K. C., Marunde, M. R., Das, A., Velasco, P. T., Kuhns, B. D., Marty, M. T., Jiang, H., Luan, C. H., Sligar, S. G. & Klein, W. L., Apr 1 2015, In : PLoS One. 10, 4, e0125263.

Research output: Contribution to journalArticle

Synaptic Membranes
amyloid
Oligomers
Amyloid
binding sites
11 Citations (Scopus)

Novel high content screen detects compounds that promote neurite regeneration from cochlear spiral ganglion neurons

Whitlon, D. S., Grover, M., Dunne, S. F., Richter, S., Luan, C-H. & Richter, C-P., Nov 2 2015, In : Scientific Reports. 5, 15960.

Research output: Contribution to journalArticle

Spiral Ganglion
Cochlea
Neurites
Regeneration
Neurons
2014
5 Citations (Scopus)

Ligand screening using fluorescence thermal shift analysis (FTS)

Luan, C-H., Light, S. H., Dunne, S. F. & Anderson, W. F., Jan 1 2014, In : Methods in Molecular Biology. 1140, p. 263-289 27 p.

Research output: Contribution to journalArticle

Hot Temperature
Fluorescence
Ligands
Genomics
Protein Unfolding
2 Citations (Scopus)
Staphylococcal Protein A
Metabolism
Proteins
Actinobacteria
Protein Sequence Analysis
2013
19 Citations (Scopus)

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4

Krishna, S. N., Luan, C-H., Mishra, R. K., Xu, L., Scheidt, K. A., Anderson, W. F. & Bergan, R. C., Dec 5 2013, In : PLoS One. 8, 12, e81504.

Research output: Contribution to journalArticle

MAP Kinase Kinase 4
mitogen-activated protein kinase kinase
prostatic neoplasms
Assays
Prostatic Neoplasms
17 Citations (Scopus)

Antagonism of L-type Ca2+ channels CaV1.3 and Ca V1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics

Kang, S., Cooper, G., Dunne, S. F., Luan, C-H., Surmeier Jr, D. J. & Silverman, R. B., Jul 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4365-4373 9 p.

Research output: Contribution to journalArticle

Pyrans
L-Type Calcium Channels
Binding Sites
Isradipine
Electrophysiology
16 Citations (Scopus)
L-Type Calcium Channels
Calcium Channel Blockers
Structure-Activity Relationship
Parkinson Disease
Dopaminergic Neurons
36 Citations (Scopus)

Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential

Jiao, L., Ouyang, S., Liang, M., Niu, F., Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C-H., Li, D. & Liu, Z. J., Jun 1 2013, In : Journal of virology. 87, 12, p. 6829-6839 11 p.

Research output: Contribution to journalArticle

suramin
nucleocapsid proteins
Nucleocapsid Proteins
Suramin
thrombocytopenia
2012
82 Citations (Scopus)

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Kang, S., Cooper, G., Dunne, S. F., Dusel, B., Luan, C-H., Surmeier Jr, D. J. & Silverman, R. B., Nov 26 2012, In : Nature communications. 3, 1146.

Research output: Contribution to journalArticle

Parkinson disease
L-Type Calcium Channels
Calcium Channel Blockers
Parkinson Disease
calcium
153 Citations (Scopus)

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. B., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. L., Jin, P., Alečković, M., LeRoy, G., Kang, Y., Sudderth, J. A., DeBerardinis, R. J., Luan, C-H., Chen, G. Z., Muller, S. & 12 others, Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C. & Chen, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 585-600 16 p.

Research output: Contribution to journalArticle

Phosphoglycerate Mutase
Glycolysis
Growth
Pentose Phosphate Pathway
Neoplasms
97 Citations (Scopus)

Single-cell mass cytometry adapted to measurements of the cell cycle

Behbehani, G. K., Bendall, S. C., Clutter, M. R., Fantl, W. J. & Nolan, G. P., Jul 1 2012, In : Cytometry Part A. 81 A, 7, p. 552-566 15 p.

Research output: Contribution to journalArticle

Cell Cycle
Antibodies
Transition Elements
Bone Marrow
Cyclin B1
2011
49 Citations (Scopus)

Fluorescent cell barcoding for multiplex flow cytometry

Krutzik, P. O., Clutter, M. R., Trejo, A. & Nolan, G. P., Jan 1 2011, In : Current Protocols in Cytometry. SUPPL.55, 6.31.

Research output: Contribution to journalArticle

Flow cytometry
Fluorescent Dyes
Multiplexing
Labeling
Flow Cytometry
19 Citations (Scopus)

High-throughput screen for identifying small molecules that target fungal zinc homeostasis

Simm, C., Luan, C-H., Weiss, E. L. & O'Halloran, T. V., Sep 29 2011, In : PloS one. 6, 9, e25136.

Research output: Contribution to journalArticle

Zinc
homeostasis
Homeostasis
zinc
Throughput
5 Citations (Scopus)

Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events

Heffner, G. C., Clutter, M. R., Nolan, G. P. & Weissman, I. L., Nov 1 2011, In : Stem Cells. 29, 11, p. 1774-1782 9 p.

Research output: Contribution to journalArticle

Megakaryocytes
Population
Hematopoietic Stem Cells
Proteins
Flow Cytometry
30 Citations (Scopus)

Targeting MgrA-mediated virulence regulation in Staphylococcus aureus

Sun, F., Zhou, L., Zhao, B. C., Deng, X., Cho, H., Yi, C., Jian, X., Song, C. X., Luan, C-H., Bae, T., Li, Z. & He, C., Aug 26 2011, In : Chemistry and Biology. 18, 8, p. 1032-1041 10 p.

Research output: Contribution to journalArticle

Virulence
Staphylococcus aureus
Anti-Bacterial Agents
Fluorescence Polarization
DNA
2010
30 Citations (Scopus)

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca 2+ channels Ca V 1.3 and Ca V 1.2

Chang, C. C., Cao, S., Kang, S., Kai, L., Tian, X., Pandey, P., Dunne, S. F., Luan, C-H., Surmeier Jr, D. J. & Silverman, R. B., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3147-3158 12 p.

Research output: Contribution to journalArticle

Neurons
Electric potential
Antihypertensive Agents
Isradipine
Dihydropyridines
17 Citations (Scopus)

Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry

Clutter, M. R., Heffner, G. C., Krutzik, P. O., Sachen, K. L. & Nolan, G. P., Nov 1 2010, In : Cytometry Part A. 77, 11, p. 1020-1031 12 p.

Research output: Contribution to journalArticle

Flow Cytometry
Phosphotransferases
Signal-To-Noise Ratio
Regulatory T-Lymphocytes
Immune System
2008
4 Citations (Scopus)

A high throughput platform for eukaryotic genes.

Chen, Y., Qiu, S., Luan, C. H. & Luo, M., Jan 1 2008, In : Methods in molecular biology (Clifton, N.J.). 426, p. 209-220 12 p.

Research output: Contribution to journalArticle

Organism Cloning
Proteomics
Genes
Proteins
Automation
139 Citations (Scopus)

High-content single-cell drug screening with phosphospecific flow cytometry

Krutzik, P. O., Crane, J. M., Clutter, M. R. & Nolan, G. P., Jan 1 2008, In : Nature Chemical Biology. 4, 2, p. 132-142 11 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Flow Cytometry
Drug Discovery
Phosphotransferases
Small Molecule Libraries
2007
16 Citations (Scopus)

Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groups

Velu, S. E., Mou, L., Luan, C. H., Yang, Z. W., DeLucas, L. J., Brouillette, C. G. & Brouillette, W. J., May 31 2007, In : Journal of Medicinal Chemistry. 50, 11, p. 2612-2621 10 p.

Research output: Contribution to journalArticle

Esterases
Ligases
Amides
Detergents
Dimers
6 Citations (Scopus)

Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins

Chen, Y., Qiu, S., Luan, C. H. & Luo, M., Jul 30 2007, In : BMC Biotechnology. 7, 45.

Research output: Contribution to journalArticle

Organism Cloning
Proteins
Genomics
Proteomics
Genes
2005
98 Citations (Scopus)

Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry

Krutzik, P. O., Clutter, M. R. & Nolan, G. P., Aug 15 2005, In : Journal of Immunology. 175, 4, p. 2357-2365 9 p.

Research output: Contribution to journalArticle

Phosphoproteins
Flow Cytometry
Population
Staining and Labeling
Monocytes
64 Citations (Scopus)

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3

Chlewicki, L. K., Holler, P. D., Monti, B. C., Clutter, M. R. & Kranz, D. M., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Mutation
Major Histocompatibility Complex
Peptides
81 Citations (Scopus)

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

Ganesh, V. K., Muller, N., Judge, K., Luan, C. H., Padmanabhan, R. & Murthy, K. H. M., Jan 3 2005, In : Bioorganic and Medicinal Chemistry. 13, 1, p. 257-264 8 p.

Research output: Contribution to journalArticle

West Nile virus
Dengue
Viruses
Peptide Hydrolases
Flavivirus
32 Citations (Scopus)

Improving solubility of Shewanella oneidensis MR-1 and Clostridium thermocellum JW-20 proteins expressed into Esherichia coli

Kataeva, I., Chang, J., Xu, H., Luan, C. H., Zhou, J., Uversky, V. N., Lin, D., Horanyi, P., Liu, Z. J., Ljungdahl, L. G., Rose, J., Luo, M. & Wang, B. C., Nov 1 2005, In : Journal of Proteome Research. 4, 6, p. 1942-1951 10 p.

Research output: Contribution to journalArticle

Clostridium thermocellum
Shewanella
Clostridium
Solubility
Maltose-Binding Proteins
10 Citations (Scopus)

Protein production and crystallization at SECSG - An overview

Wang, B. C., Adams, M. W. W., Dailey, H., DeLucas, L., Luo, M., Rose, J., Bunzel, R., Dailey, T., Habel, J., Horanyi, P., Jenney, F. E., Kataeva, I., Lee, H. S., Li, S., Li, T., Lin, D., Liu, Z. J., Luan, C. H., Mayer, M., Nagy, L. & 7 others, Newton, M. G., Ng, J., Poole, F. L., Shah, A., Shah, C., Sugar, F. J. & Xu, H., Sep 1 2005, In : Journal of Structural and Functional Genomics. 6, 2-3, p. 233-243 11 p.

Research output: Contribution to journalArticle

Genomics
Crystallization
Proteins
Pipelines
Pyrococcus furiosus
11 Citations (Scopus)

Tethered dimer inhibitors of NAD synthetase: Parallel synthesis of an aryl-substituted SAR library

Velu, S. E., Luan, C. H., DeLucas, L. J., Brouillette, C. G. & Brouillette, W. J., Nov 1 2005, In : Journal of Combinatorial Chemistry. 7, 6, p. 898-904 7 p.

Research output: Contribution to journalArticle

Enzyme inhibition
Indoles
Enzyme activity
Dimer
Isomers
2004
92 Citations (Scopus)

High-throughput expression of C. elegans proteins

Luan, C. H., Qiu, S., Finley, J. B., Carson, M., Gray, R. J., Huang, W., Johnson, D., Tsao, J., Reboul, J., Vaglio, P., Hill, D. E., Vidal, M., DeLucas, L. L. & Luo, M., Jan 1 2004, In : Genome Research. 14, 10 B, p. 2102-2110 9 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans Proteins
Open Reading Frames
Recombinant Proteins
Caenorhabditis elegans
Robotics
19 Citations (Scopus)

Structural genomics for Caenorhabditis elegans: High throughput protein expression analysis

Finley, J. B., Qiu, S. H., Luan, C. H. & Luo, M., Jan 1 2004, In : Protein Expression and Purification. 34, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Genomics
Recombinant Proteins
Proteins
Libraries
6 Citations (Scopus)

Structural genomics of Caenorhabditis elegans: Structure of the BAG domain

Symersky, J., Zhang, Y., Schormann, N., Li, S., Bunzel, R., Pruett, P., Luan, C. H. & Luo, M., Sep 1 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 9, p. 1606-1610 5 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Heat-Shock Proteins
Genomics
Adenosine Triphosphate
Proteins
2003
3 Citations (Scopus)

Structural Genomics of Caenorhabditis elegans: Structure of Dihydropteridine Reductase

Symersky, J., Li, S., Carson, M., Luo, D., Luan, C. H. & Luo, M., Dec 1 2003, In : Proteins: Structure, Function and Genetics. 53, 4, p. 944-946 3 p.

Research output: Contribution to journalArticle

Dihydropteridine Reductase
Caenorhabditis elegans Proteins
X ray crystallography
NAD
Animals
19 Citations (Scopus)

Tethered dimers as NAD synthetase inhibitors with antibacterial activity

Velu, S. E., Cristofoli, W. A., Garcia, G. J., Brouillette, C. G., Pierson, M. C., Luan, C. H., DeLucas, L. J. & Brouillette, W. J., Jul 17 2003, In : Journal of Medicinal Chemistry. 46, 15, p. 3371-3381 11 p.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Enzyme Inhibitors
Gram-Negative Bacteria
Ether
Oxygen
2002
77 Citations (Scopus)

Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain

Li, S., Finley, J., Liu, Z. J., Qiu, S. H., Chen, H., Luan, C. H., Carson, M., Tsao, J., Johnson, D., Lin, G., Zhao, J., Thomas, W., Nagy, L. A., Sha, B., DeLucas, L. J., Wang, B. C. & Luo, M., Dec 13 2002, In : Journal of Biological Chemistry. 277, 50, p. 48596-48601 6 p.

Research output: Contribution to journalArticle

Cytoskeleton
Glycine
Crystal structure
Proteins
Caenorhabditis elegans Proteins