Life Sciences Graduate Programs

Research Output

The β-secretase, BACE: A prime drug target for Alzheimer's disease

Vassar, R., Nov 26 2001, In : Journal of Molecular Neuroscience. 17, 2, p. 157-170 14 p.

Research output: Contribution to journalArticle

155 Scopus citations

The β-secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential

Vassar, R., Kovacs, D. M., Yan, R. & Wong, P. C., Oct 14 2009, In : Journal of Neuroscience. 29, 41, p. 12787-12794 8 p.

Research output: Contribution to journalArticle

371 Scopus citations

Thin client performance for remote 3-D image display.

Lai, A., Nieh, J., Laine, A. & Starren, J., 2003, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 1 p.

Research output: Contribution to journalArticle

Three-dimensional display of positron emission tomography of the heart

Miller, T. R., Starren, J. B. & Grothe, R. A., Jan 1 1988, In : Journal of Nuclear Medicine. 29, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice

Vassar, R., Rosenberg, M., Ross, S., Tyner, A. & Fuchs, E., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 5, p. 1563-1567 5 p.

Research output: Contribution to journalArticle

284 Scopus citations

Topographic organization of sensory projections to the olfactory bulb

Vassar, R., Chao, S. K., Sitcheran, R., Nuñez, J. M., Vosshall, L. B. & Axel, R., Dec 16 1994, In : Cell. 79, 6, p. 981-991 11 p.

Research output: Contribution to journalArticle

973 Scopus citations

Training digital divide seniors to use a telehealth system: a remote training approach.

Lai, A. M., Kaufman, D. R. & Starren, J., Jan 1 2006, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. p. 459-463 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

Vannini, I., Wise, P. M., Challagundla, K. B., Plousiou, M., Raffini, M., Bandini, E., Fanini, F., Paliaga, G., Crawford, M., Ferracin, M., Ivan, C., Fabris, L., Davuluri, R. V., Guo, Z., Cortez, M. A., Zhang, X., Chen, L., Zhang, S., Fernandez-Cymering, C., Han, L. & 14 others, Carloni, S., Salvi, S., Ling, H., Murtadha, M., Neviani, P., Gitlitz, B. J., Laird-Offringa, I. A., Nana-Sinkam, P., Negrini, M., Liang, H., Amadori, D., Cimmino, A., Fabbri, M. & Calin, G. A., Dec 1 2017, In : Nature communications. 8, 1, 1801.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
1 Scopus citations

Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation

Vassar, R. & Fuchs, E., Jan 1 1991, In : Genes and Development. 5, 5, p. 714-727 14 p.

Research output: Contribution to journalArticle

354 Scopus citations

Transgenic overexpression of transforming growth factor α bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

Vassar, R., Hutton, M. E. & Fuchs, E., Jan 1 1992, In : Molecular and cellular biology. 12, 10, p. 4643-4653 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

Tree-based position weight matrix approach to model transcription factor binding site profiles

Bi, Y., Kim, H., Gupta, R. & Davuluri, R. V., Sep 2 2011, In : PloS one. 6, 9, e24210.

Research output: Contribution to journalArticle

14 Scopus citations
20 Scopus citations

Tumor stroma and the antitumor immune response

Zhang, B., Rowley, D. A. & Schreiber, H., Jan 1 2008, Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal. Springer New York, p. 281-294 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Understanding dimensions of complexity in nurse case managers' workflow in a telemedicine program.

Kaufman, D. R., Pevzner, J., Rodriguez, M., McGuiness, C., Moreno, V. I., Cimino, J. I., Shea, S., Weinstock, R. S. & Starren, J., 2007, In : AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. 1 p.

Research output: Contribution to journalArticle

Understanding workflow in telehealth video visits: Observations from the IDEATel project

Kaufman, D. R., Pevzner, J., Rodriguez, M., Cimino, J. J., Ebner, S., Fields, L., Moreno, V., McGuiness, C., Weinstock, R. S., Shea, S. & Starren, J., Aug 1 2009, In : Journal of Biomedical Informatics. 42, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Usability in the real world: Assessing medical information technologies in patients' homes

Kaufman, D. R., Patel, V. L., Hilliman, C., Morin, P. C., Pevzner, J., Weinstock, R. S., Goland, R., Shea, S. & Starren, J., Jan 1 2003, In : Journal of Biomedical Informatics. 36, 1-2, p. 45-60 16 p.

Research output: Contribution to journalArticle

150 Scopus citations

Use of the Extensible Stylesheet Language (XSL) for medical data transformation.

Seol, Y. H., Johnson, S. B. & Starren, J., 1999, In : Proceedings / AMIA ... Annual Symposium. AMIA Symposium. p. 142-146 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Use of three computer training methods in elderly underserved rural patients enrolled in a diabetes telemedicine program

Robinson, K. S., Morin, P. C., Shupe, J. A. C., Izquierdo, R., Ploutz-Snyder, R., Meyer, S., Teresi, J. A., Starren, J., Shea, S. & Weinstock, R. S., May 1 2010, In : CIN - Computers Informatics Nursing. 28, 3, p. 172-177 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
38 Scopus citations

Using machine learning to integrate socio-behavioral factors in predicting cardiovascular-related mortality risk

Wang, H., Li, Y., Ning, H., Wilkins, J. T., Lloyd-Jones, D. M. & Luo, Y., Aug 21 2019, MEDINFO 2019: Health and Wellbeing e-Networks for All - Proceedings of the 17th World Congress on Medical and Health Informatics. Seroussi, B., Ohno-Machado, L., Ohno-Machado, L. & Seroussi, B. (eds.). IOS Press, p. 433-437 5 p. (Studies in Health Technology and Informatics; vol. 264).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Using natural language processing and machine learning to identify breast cancer local recurrence

Zeng, Z., Espino, S., Roy, A., Li, X., Khan, S. A., Clare, S. E., Jiang, X., Neapolitan, R. & Luo, Y., Dec 28 2018, In : BMC bioinformatics. 19, 498.

Research output: Contribution to journalArticle

8 Scopus citations

US Transplant Policy Should Strengthen Bridges, Not Build Walls

Gordon, E. J. & Gill, J. S., Jan 1 2016, In : American Journal of Transplantation. 16, 6, p. 1645-1646 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Validation of a decision regret scale

Brehaut, J. C., O'Connor, A. M., Wood, T. J., Hack, T. F., Siminoff, L., Gordon, E. & Feldman-Stewart, D., Jul 1 2003, In : Medical Decision Making. 23, 4, p. 281-292 12 p.

Research output: Contribution to journalReview article

483 Scopus citations

Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus

Laskowski, A. I., Neems, D. S., Laster, K., Strojny-Okyere, C., Rice, E. L., Konieczna, I. M., Voss, J. H., Mathew, J. M., Leventhal, J. R., Ramsey-Goldman, R., Smith, E. D. & Kosak, S. T., Dec 1 2019, In : Scientific reports. 9, 1, 8011.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Verbal and nonverbal memory in primary progressive aphasia: The Three Words-Three Shapes Test

Weintraub, S., Rogalski, E., Shaw, E., Sawlani, S., Rademaker, A., Wieneke, C. & Mesulam, M. M., Jan 1 2013, In : Behavioural Neurology. 26, 1-2, p. 67-76 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Vestibular Reflexes

Hain, T. C. & Cherchi, M., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 643-646 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vision loss in a teenage girl with postconcussion syndrome

Al-Khersan, H., Hain, T. & Grassi, M. A., Jan 1 2017, In : JAMA ophthalmology. 135, 1, p. 75-76 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

What do ER physicians really want? A method for elucidating ER information needs.

Shablinsky, I., Starren, J. & Friedman, C., 1999, In : Proceedings / AMIA ... Annual Symposium. AMIA Symposium. p. 390-394 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

What do pauses in narrative production reveal about the nature of word retrieval deficits in PPA?

Mack, J. E., Chandler, S. D., Meltzer-Asscher, A., Rogalski, E., Weintraub, S., Mesulam, M. M. & Thompson, C. K., Oct 1 2015, In : Neuropsychologia. 77, p. 211-222 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

What “race” cannot tell us about access to kidney transplantation

Gordon, E. J., Jan 1 2002, In : Cambridge Quarterly of Healthcare Ethics. 11, 2, p. 134-141 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

When Oral Consent Will Do

Gordon, E. J., Jan 1 2000, In : Field Methods. 12, 3, p. 235-238 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

When seconds are counted: tools for mobile, high-resolution time-motion studies.

Starren, J., Chan, S., Tahil, F. & White, T., 2000, In : Proceedings / AMIA ... Annual Symposium. AMIA Symposium. p. 833-837 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
12 Scopus citations
7 Scopus citations

Words and objects at the tip of the left temporal lobe in primary progressive aphasia

Mesulam, M-M., Wieneke, C., Hurley, R., Rademaker, A., Thompson, C., Weintraub, S. & Rogalski, E., Jan 2013, In : Brain. 136, p. 601618

Research output: Contribution to journalArticle

109 Scopus citations

X11 proteins regulate the translocation of amyloid β-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by β-site-cleaving enzyme in brain

Saito, Y., Sano, Y., Vassar, R., Gandy, S., Nakaya, T., Yamamoto, T. & Suzuki, T., Dec 19 2008, In : Journal of Biological Chemistry. 283, 51, p. 35763-35771 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
48 Scopus citations
109 Scopus citations

β-secretase (BACE) as a drug target for Alzheimer's disease

Vassar, R., Dec 7 2002, In : Advanced Drug Delivery Reviews. 54, 12, p. 1589-1602 14 p.

Research output: Contribution to journalArticle

183 Scopus citations

β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C. & 4 others, Collins, F., Treanor, J., Rogers, G. & Citron, M., Oct 22 1999, In : Science. 286, 5440, p. 735-741 7 p.

Research output: Contribution to journalArticle

2994 Scopus citations

β-Secretase Inhibition

Vassar, R., Jun 15 2016, Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Elsevier Inc, p. 39-62 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

Hitt, B., Riordan, S. M., Kukreja, L., Eimer, W. A., Rajapaksha, T. W. & Vassar, R., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 38408-38425 18 p.

Research output: Contribution to journalArticle

95 Scopus citations

β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis

Zhao, J., Fu, Y., Yasvoina, M., Shao, P., Hitt, B., O'Connor, T., Logan, S., Maus, E., Citron, M., Berry, R., Binder, L. & Vassar, R., Apr 4 2007, In : Journal of Neuroscience. 27, 14, p. 3639-3649 11 p.

Research output: Contribution to journalArticle

262 Scopus citations