Life Sciences Graduate Programs

Research Output

2014

Ewald, J Richard

Hain, T. C., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 232 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Function, therapeutic potential and cell biology of BACE proteases: Current status and future prospects

Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C. & Lichtenthaler, S. F., Jul 2014, In : Journal of neurochemistry. 130, 1, p. 4-28 25 p.

Research output: Contribution to journalReview article

207 Scopus citations
26 Scopus citations

Genome-wide mapping of RNA pol-II promoter usage in mouse tissues by chiP-Seq

Pal, S., Gupta, R. & Davuluri, R. V., Jan 1 2014, Cancer Genomics and Proteomics: Methods and Protocols. Humana Press Inc., p. 1-9 9 p. (Methods in Molecular Biology; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome-wide mapping of RNA Pol-II promoter usage in mouse tissues by ChIP-seq

Pal, S., Gupta, R. & Davuluri, R. V., 2014, Cancer Genomics and Proteomics: Methods and Protocols. Humana Press Inc, p. 1-9 9 p. (Methods in Molecular Biology; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Genome-Wide Mapping of RNA Pol-II Promoter Usage in Mouse Tissues by ChIP-Seq

Sharmistha, P., Gupta, R. & Davuluri, R. V., 2014, Cancer Genomics and Proteomics Methods in Molecular Biology Volume 1176. Wajapeyee, N. (ed.). New York: Springer, p. 1-9

Research output: Chapter in Book/Report/Conference proceedingChapter

Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes

Pal, S., Bi, Y., MacYszyn, L., Showe, L. C., O'Rourke, D. M. & Davuluri, R. V., Apr 2014, In : Nucleic acids research. 42, 8, p. e64

Research output: Contribution to journalArticle

36 Scopus citations

Longitudinal neuropsychological performance of cognitive SuperAgers

Gefen, T., Shaw, E., Whitney, K., Martersteck, A., Stratton, J., Rademaker, A., Weintraub, S., Mesulam, M. M. & Rogalski, E., Jan 1 2014, In : Journal of the American Geriatrics Society. 62, 8, p. 1598-1600 3 p.

Research output: Contribution to journalLetter

26 Scopus citations

Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

Farfara, D., Tuby, H., Trudler, D., Doron-Mandel, E., Maltz, L., Vassar, R. J., Frenkel, D. & Oron, U., Jan 1 2014, In : Journal of Molecular Neuroscience. 55, 2, p. 430-436 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. M., Guo, X., Liu, J., Bielinski, S. J., Yanek, L. R., Nalls, M. A., Comeau, M. E., Rasmussen-Torvik, L. J., Jensen, R. A., Evans, D. S., Sun, Y. V., An, P., Patel, S. R., Lu, Y., Long, J., Armstrong, L. L. & 32 others, Wagenknecht, L., Yang, L., Snively, B. M., Palmer, N. D., Mudgal, P., Langefeld, C. D., Keene, K. L., Freedman, B. I., Mychaleckyj, J. C., Nayak, U., Raffel, L. J., Goodarzi, M. O., Chen, Y. D. I., Taylor, H. A., Correa, A., Sims, M., Couper, D., Pankow, J. S., Boerwinkle, E., Adeyemo, A., Doumatey, A., Hayes, M. G., Starren, J., Chisholm, R. L., Greenland, P., Kho, A. N., Lowe, W. L., Smith, M. E., Thompson, W. K., Cornelis, M., The MAGIC investigators & The GIANT consortium, Aug 7 2014, In : PLoS genetics. 10, 8, e1004517.

Research output: Contribution to journalArticle

108 Scopus citations

MiR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma

Mathew, L. K., Skuli, N., Mucaj, V., Lee, S. S., Zinn, P. O., Sathyan, P., Imtiyaz, H. Z., Zhang, Z., Davuluri, R. V., Rao, S., Venneti, S., Lal, P., Lathia, J. D., Rich, J. N., Keith, B., Minn, A. J. & Simon, M. C., Jan 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 291-296 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Molecular neurodegeneration: Basic biology and disease pathways

Vassar, R. & Zheng, H., Sep 23 2014, In : Molecular neurodegeneration. 9, 1, 34.

Research output: Contribution to journalReview article

2 Scopus citations

PGS: A tool for association study of high-dimensional microRNA expression data with repeated measures

Zheng, Y., Fei, Z., Zhang, W., Starren, J. B., Liu, L., Baccarelli, A. A., Li, Y. & Hou, L., Apr 2 2014, In : Bioinformatics. 30, 19, p. 2802-2807 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Primary progressive aphasia and the evolving neurology of the language network

Mesulam, M. M., Rogalski, E. J., Wieneke, C., Hurley, R. S., Geula, C., Bigio, E. H., Thompson, C. K. & Weintraub, S., Jan 1 2014, In : Nature Reviews Neurology. 10, 10, p. 554-569 16 p.

Research output: Contribution to journalReview article

108 Scopus citations

Protein kinase a activation enhances β-catenin transcriptional activity through nuclear localization to PML bodies

Zhang, M., Mahoney, E., Zuo, T., Manchanda, P. K., Davuluri, R. V. & Kirschner, L. S., Oct 9 2014, In : PloS one. 9, 10, 0109523.

Research output: Contribution to journalArticle

22 Scopus citations

Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline

Stong, N., Deng, Z., Gupta, R., Hu, S., Paul, S., Weiner, A. K., Eichler, E. E., Graves, T., Fronick, C. C., Courtney, L., Wilson, R. K., Lieberman, P. M., Davuluri, R. V. & Riethman, H., Jun 2014, In : Genome research. 24, 6, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Yan, R. & Vassar, R., Mar 1 2014, In : The Lancet Neurology. 13, 3, p. 319-329 11 p.

Research output: Contribution to journalReview article

341 Scopus citations

Telehealth

Starren, J. B., Nesbitt, T. S. & Chiang, M. F., Jan 1 2014, Biomedical Informatics: Computer Applications in Health Care and Biomedicine: Fourth Edition. Springer London, p. 541-560 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

The normal and pathologic roles of the Alzheimer's β-secretase, BACE1

Kandalepas, P. C. & Vassar, R., Jan 1 2014, In : Current Alzheimer Research. 11, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Vestibular Reflexes

Hain, T. C. & Cherchi, M., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 643-646 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

A cortical pathway to olfactory naming: Evidence from primary progressive aphasia

Olofsson, J. K., Rogalski, E., Harrison, T., Mesulam, M. M. & Gottfried, J. A., Apr 2013, In : Brain. 136, 4, p. 1245-1259 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD

Vassar, R., Oct 16 2013, In : Neuron. 80, 2, p. 250-253 4 p.

Research output: Contribution to journalShort survey

14 Scopus citations

ADAR1 forms a complex with dicer to promote MicroRNA processing and RNA-induced gene silencing

Ota, H., Sakurai, M., Gupta, R., Valente, L., Wulff, B. E., Ariyoshi, K., Iizasa, H., Davuluri, R. V. & Nishikura, K., Apr 25 2013, In : Cell. 153, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

161 Scopus citations

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and alzheimer's disease Aβ production

Buggia-Prévot, V., Fernandez, C. G., Udayar, V., Vetrivel, K. S., Elie, A., Roseman, J., Sasse, V. A., Lefkow, M., Meckler, X., Bhattacharyya, S., George, M., Kar, S., Bindokas, V. P., Parent, A. T., Rajendran, L., Band, H., Vassar, R. & Thinakaran, G., Dec 26 2013, In : Cell reports. 5, 6, p. 1552-1563 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

A novel frontal pathway underlies verbal fluency in primary progressive aphasia

Catani, M., Mesulam, M. M., Jakobsen, E., Malik, F., Martersteck, A., Wieneke, C., Thompson, C. K., Thiebaut De Schotten, M., Dell'Acqua, F., Weintraub, S. & Rogalski, E., Aug 2013, In : Brain. 136, 8, p. 2619-2628 10 p.

Research output: Contribution to journalArticle

202 Scopus citations

Are there susceptibility factors for primary progressive aphasia?

Rogalski, E., Weintraub, S. & Mesulam, M. M., Nov 1 2013, In : Brain and Language. 127, 2, p. 135-138 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
37 Scopus citations

Bilateral vestibular loss

Hain, T. C., Cherchi, M. & Yacovino, D. A., Oct 1 2013, In : Seminars in Neurology. 33, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

Ling, H., Spizzo, R., Atlasi, Y., Nicoloso, M., Shimizu, M., Redis, R. S., Nishida, N., Gafà, R., Song, J., Guo, Z., Ivan, C., Barbarotto, E., De Vries, I., Zhang, X., Ferracin, M., Churchman, M., Van Galen, J. F., Beverloo, B. H., Shariati, M., Haderk, F. & 33 others, Estecio, M. R., Garcia-Manero, G., Patijn, G. A., Gotley, D. C., Bhardwaj, V., Shureiqi, I., Sen, S., Multani, A. S., Welsh, J., Yamamoto, K., Taniguchi, I., Song, M. A., Gallinger, S., Casey, G., Thibodeau, S. N., Le Marchand, L., Tiirikainen, M., Mani, S. A., Zhang, W., Davuluri, R. V., Mimori, K., Mori, M., Sieuwerts, A. M., Martens, J. W. M., Tomlinson, I., Negrini, M., Berindan-Neagoe, I., Foekens, J. A., Hamilton, S. R., Lanza, G., Kopetz, S., Fodde, R. & Calin, G. A., Sep 1 2013, In : Genome research. 23, 9, p. 1446-1461 16 p.

Research output: Contribution to journalArticle

363 Scopus citations

Clinical characteristics of cervicogenic-related dizziness and vertigo

Yacovino, D. A. & Hain, T. C., Oct 1 2013, In : Seminars in Neurology. 33, 3, p. 244-255 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

Veeraraghavalu, K., Zhang, C., Miller, S., Hefendehl, J. K., Rajapaksha, T. W., Ulrich, J., Jucker, M., Holtzman, D. M., Tanzi, R. E., Vassar, R. & Sisodia, S. S., Jan 1 2013, In : Science. 340, 6135, 1 p.

Research output: Contribution to journalComment/debate

98 Scopus citations

Crossing the omic chasm: A time for omic ancillary systems

Starren, J. B., Williams, M. S. & Bottinger, E. P., Mar 27 2013, In : JAMA - Journal of the American Medical Association. 309, 12, p. 1237-1238 2 p.

Research output: Contribution to journalShort survey

51 Scopus citations

Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis

Sadleir, K. R., Bennett, D. A., Schneider, J. A. & Vassar, R., Nov 26 2013, In : Current Alzheimer Research. 10, 8, p. 785-789 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia

Glass, C., Wuertzer, C., Cui, X., Bi, Y., Davuluri, R., Xiao, Y. Y., Wilson, M., Owens, K., Zhang, Y. & Perkins, A., Jun 27 2013, In : PloS one. 8, 6, e67134.

Research output: Contribution to journalArticle

31 Scopus citations

HINCUTs in cancer: Hypoxia-induced noncoding ultraconserved transcripts

Ferdin, J., Nishida, N., Wu, X., Nicoloso, M. S., Shah, M. Y., Devlin, C., Ling, H., Shimizu, M., Kumar, K., Cortez, M. A., Ferracin, M., Bi, Y., Yang, D., Czerniak, B., Zhang, W., Schmittgen, T. D., Voorhoeve, M. P., Reginato, M. J., Negrini, M., Davuluri, R. V. & 3 others, Kunej, T., Ivan, M. & Calin, G. A., Dec 1 2013, In : Cell Death and Differentiation. 20, 12, p. 1675-1687 13 p.

Research output: Contribution to journalArticle

63 Scopus citations

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the alzheimer disease mouse model: In vivo and in vitro studies

Avrahami, L., Farfara, D., Shaham-Kol, M., Vassar, R., Frenkel, D. & Eldar-Finkelman, H., Jan 11 2013, In : Journal of Biological Chemistry. 288, 2, p. 1295-1306 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

Isoform level expression profiles provide better cancer signatures than gene level expression profiles

Zhang, Z., Pal, S., Bi, Y., Tchou, J. & Davuluri, R. V., Apr 17 2013, In : Genome Medicine. 5, 4, 33.

Research output: Contribution to journalArticle

33 Scopus citations

Naming vs knowing faces in primary progressive aphasia: A tale of 2 hemispheres

Gefen, T., Wieneke, C., Martersteck, A., Whitney, K., Weintraub, S., Mesulam, M. M. & Rogalski, E., Aug 13 2013, In : Neurology. 81, 7, p. 658-664 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
112 Scopus citations
19 Scopus citations

Opportunities for genomic clinical decision support interventions

Overby, C. L., Kohane, I., Kannry, J. L., Williams, M. S., Starren, J. B., Bottinger, E., Gottesman, O., Denny, J. C., Weng, C., Tarczy-Hornoch, P. & Hripcsak, G., Oct 1 2013, In : Genetics in Medicine. 15, 10, p. 817-823 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Practical challenges in integrating genomic data into the electronic health record

Kho, A. N., Rasmussen, L. V., Connolly, J. J., Peissig, P. L., Starren, J., Hakonarson, H. & Hayes, M. G., Oct 1 2013, In : Genetics in Medicine. 15, 10, p. 772-778 7 p.

Research output: Contribution to journalReview article

43 Scopus citations

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and alzheimer disease-like transgenic mouse models

Frost, J. L., Le, K. X., Cynis, H., Ekpo, E., Kleinschmidt, M., Palmour, R. M., Ervin, F. R., Snigdha, S., Cotman, C. W., Saido, T. C., Vassar, R. J., George-Hyslop, P. S., Ikezu, T., Schilling, S., Demuth, H. U. & Lemere, C. A., Aug 1 2013, In : American Journal of Pathology. 183, 2, p. 369-381 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

Kandalepas, P. C., Sadleir, K. R., Eimer, W. A., Zhao, J., Nicholson, D. A. & Vassar, R., Sep 1 2013, In : Acta Neuropathologica. 126, 3, p. 329-352 24 p.

Research output: Contribution to journalArticle

121 Scopus citations

Verbal and nonverbal memory in primary progressive aphasia: The Three Words-Three Shapes Test

Weintraub, S., Rogalski, E., Shaw, E., Sawlani, S., Rademaker, A., Wieneke, C. & Mesulam, M. M., Jan 1 2013, In : Behavioural Neurology. 26, 1-2, p. 67-76 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Words and objects at the tip of the left temporal lobe in primary progressive aphasia

Mesulam, M-M., Wieneke, C., Hurley, R., Rademaker, A., Thompson, C., Weintraub, S. & Rogalski, E., Jan 2013, In : Brain. 136, p. 601618

Research output: Contribution to journalArticle

109 Scopus citations
48 Scopus citations
2012

Age-related changes in parahippocampal white matter integrity: A diffusion tensor imaging study

Rogalski, E., Stebbins, G. T., Barnes, C. A., Murphy, C. M., Stoub, T. R., George, S., Ferrari, C., Shah, R. C. & deToledo-Morrell, L., Jul 1 2012, In : Neuropsychologia. 50, 8, p. 1759-1765 7 p.

Research output: Contribution to journalArticle

26 Scopus citations